Assessing available information on the burden of sepsis: global estimates of incidence, prevalence and mortality
Open accessAbstract
Assessing available information on the burden of sepsis: global estimates of incidence, prevalence and mortalityObjective Sepsis is a complex and hard-to-define condition with many different interactions with other disorders.Presently, there are no estimates of the burden of sepsis and septicaemia at the global level and it was not included in the initial Global Burden of Disease study.Non-maternal sepsis has only recently received attention as a substantial global public health problem.The aim of this study was to assess available data on the burden of non-maternal sepsis, severe sepsis and septic shock in the community and to identify key gaps in information needed to estimate the global burden of sepsis.Methods Literature review of English language-based studies reporting on the incidence, prevalence, mortality or case-fatality of sepsis, severe sepsis and septic shock.The available literature was searched using the MEDLINE database of citations and abstracts of biomedical research articles published between 1980 and 2008.Findings 8 studies reported incidence of sepsis, severe sepsis or septic shock at the national level (4 from the USA and 1 from Brazil, the UK, Norway and Australia).No studies on the incidence, prevalence, mortality or case-fatality from sepsis in developing countries were found.The population sepsis incidence ranged from 22 to 240/100 000 (most plausible estimates ranged from 149 to 240/100 000); of severe sepsis from 13 to 300/100 000 (most of the estimates were between 56 and 91/100 000); and of septic shock 11/100 000.Case-fatality rate depends on the setting and severity of disease.It can reach up to 30% for sepsis, 50% for severe sepsis and 80% for septic shock.While the data were compiled using strict inclusion and exclusion criteria, a degree of uncertainty still exists regarding the reported estimates. ConclusionThe few national-level reports available allow only a very crude estimation of the incidence of sepsis in developed countries while there is apparent lack of data from developing countries.A clear and universal definition of sepsis as well as the development of a sound epidemiological framework to begin addressing the magnitude of this problem is urgently needed through research in developing countries.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Hospital-born babies in developing countries have a 3 to 20 times greater risk of neonatal infections because of poor infection-control practices.
“However, even hospital-born babies in developing countries have a three times greater to 20 times greater risk of neonatal infections because of poor infection-control practices.56, 57, 58, 59”
From Global burden of childhood pneumonia and diarrhoea (2013) · cites this paper as [58]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Bone, R. C., BALK, R. A., Cerra, F. B., Dellinger, R. P., Fein, A. M., Knaus, W. A., Schein, R. M. H., & Sibbald, W. J. (1992) · CHEST Journal · doi:10.1378/chest.101.6.1644 · Cited by 13,192 · see citing works
Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001) · Critical Care Medicine · doi:10.1097/00003246-200107000-00002 · Cited by 8,503 · see citing works
Murray, C. J. L., & López, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07492-2 · Cited by 7,007 · see citing works
The epidemiology of sepsis in the United States from 1979 through 2000
Martin, G. S., Mannino, D. M., Eaton, S., & Moss, M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022139 · Cited by 5,841 · see citing works
Evidence-based health policy—lessons from the Global Burden of Disease Study
Murray, C. J. L., & Lopez, A. D. (1996) · Science · doi:10.1126/science.274.5288.740 · Cited by 2,178 · see citing works
The Epidemiology of Severe Sepsis in Children in the United States
Watson, R. S., Carcillo, J. A., Linde‐Zwirble, W. T., Clermont, G., Lidicker, J. R., & Angus, D. C. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200207-682oc · Cited by 871 · see citing works
Epidemiology of sepsis in Germany: results from a national prospective multicenter study
Engel, C., Brunkhorst, F. M., Bone, H.-G., Brunkhorst, R. R., Gerlach, H., Grond, S., Gründling, M., Huhle, G., Jaschinski, U., John, S., et al. (2007) · Intensive Care Medicine · doi:10.1007/s00134-006-0517-7 · Cited by 609 · see citing works
Sepsis: definition, epidemiology, and diagnosis
Lever, A. M. L., & Mackenzie, I. M. J. (2007) · BMJ · doi:10.1136/bmj.39346.495880.ae · Cited by 513 · see citing works
Adult-population incidence of severe sepsis in Australian and New Zealand intensive care units
Finfer, S. R., Bellomo, R., Lipman, J., French, C., DOBB, G. J., & Myburgh, J. (2004) · Intensive Care Medicine · doi:10.1007/s00134-004-2157-0 · Cited by 441 · see citing works
Brazilian Sepsis Epidemiological Study (BASES study)
Silva, E., Pedro, M. D. A., Sogayar, A. M. C. B., Mohovic, T., Silva, C. L. O., Janiszewski, M., Cal, R. G. R., de Sousa, É. F., Abe, T. P., de Andrade, J., et al. (2004) · Critical Care · doi:10.1186/cc2892 · Cited by 408 · see citing works
Harrison, D. A., Welch, C. A., & EDDLESTON, J. M. (2006) · Critical Care · doi:10.1186/cc4854 · Cited by 300 · see citing works
Karlsson, S., Varpula, M., Ruokonen, E., Pettilä, V., Parviainen, I., Ala-Kokko, T. I., Kolho, E., & Rintala, E. M. (2007) · Intensive Care Medicine · doi:10.1007/s00134-006-0504-z · Cited by 249 · see citing works
The SEPSIS Study Group, Salvo, I., de Cian, W., Musicco, M., Langer, M., Piadena, R., Wolfler, A., Montani, C., & Magni, E. (1995) · Intensive Care Medicine · doi:10.1007/bf01740762 · Cited by 247 · see citing works
Scaling up access to antiretroviral treatment in southern Africa: who will do the job?
Kober, K., & Damme, W. V. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16597-5 · Cited by 244 · see citing works
Gender-Based Differences in Outcome in Patients With Sepsis
Eachempati, S. R. (1999) · Archives of Surgery · doi:10.1001/archsurg.134.12.1342 · Cited by 232 · see citing works
Epidemiology of Sepsis: Race, Sex, and Chronic Alcohol Abuse
Moss, M. (2005) · Clinical Infectious Diseases · doi:10.1086/432003 · Cited by 157 · see citing works
Epidemiology of sepsis in Norway in 1999
Flaatten, H. K. (2004) · Critical Care · doi:10.1186/cc2867 · Cited by 105 · see citing works
Empirical Bayes methods for stabilizing incidence rates before mapping.
Devine, O., Louis, T. A., & Halloran, M. (1994) · Epidemiology · doi:10.1097/00001648-199411000-00010 · Cited by 87 · see citing works
Hoa, N. T. T., Diep, T. S., Wain, J. R., Parry, C. M., Hien, T. T., Smith, M. D., Walsh, A. L., & White, N. J. (1998) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(98)90891-4 · Cited by 74 · see citing works
Braun, L., Riedel, A. A., & Cooper, L. M. (2004) · Journal of Managed Care Pharmacy · doi:10.18553/jmcp.2004.10.6.521 · Cited by 73 · see citing works
A literature review of the epidemiology of sepsis in Latin America
Jaimes, F. A. (2005) · Revista Panamericana de Salud Pública · doi:10.1590/s1020-49892005000800003 · Cited by 44 · see citing works
Septicaemia in a teaching hospital in Kuwait — I: Incidence and aetiology
Elhag, K. M., Mustafa, A., & Sethi, S. K. (1985) · Journal of Infection · doi:10.1016/s0163-4453(85)80004-9 · Cited by 23 · see citing works
Épidémiologie des états septiques graves
Brun‐Buisson, C. (2006) · La Presse Médicale · doi:10.1016/s0755-4982(06)74627-9 · Cited by 15 · see citing works
Incidencia estimada y análisis de la sepsis en un área de Valencia
Monterde, R. B., Diego, J. A., Monleón, S. F., Bracho, L. S.-V., Escrivá, A. A., & Reig, P. R. (2007) · Anales de Pediatría · doi:10.1157/13107391 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Global burden of childhood pneumonia and diarrhoea
Walker, C. L. F., Rudan, I., Liu, L., Nair, H., Theodoratou, E., Bhutta, Z. A., O'Brien, K. L., Campbell, H., & Black, R. E. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60222-6 · Cited by 2,356 · see citing works
Goal-Directed Resuscitation for Patients with Early Septic Shock
The ARISE Investigators and the ANZICS Clinical Trials Group (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1404380 · Cited by 2,023 · see citing works
Cecconi, M., Backer, D. D., Antonelli, M. M., Beale, R. J., Bakker, J., Hofer, C. K., Jaeschke, R., Mebazaa, A., Pinsky, M. R., Teboul, J., et al. (2014) · Intensive Care Medicine · doi:10.1007/s00134-014-3525-z · Cited by 1,779 · see citing works
Hotchkiss, R. S., Moldawer, L. L., Opal, S. M., Reinhart, K., Turnbull, I. R., & Vincent, J. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.45 · Cited by 1,720 · see citing works
Trial of early, goal-directed resuscitation for septic shock.
Mouncey, P. R., Osborn, T. M., Power, G. S., Harrison, D. A., Sadique, M. Z., Grieve, R. D., Jahan, R., Harvey, S. E., Bell, D., Bion, J. F., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1500896 · Cited by 1,604 · see citing works
The global burden of sepsis: barriers and potential solutions
Rudd, K. E., Kissoon, N., Limmathurotsakul, D., Bory, S., Mutahunga, B., Seymour, C. W., Angus, D. C., & West, T. E. (2018) · Critical Care · doi:10.1186/s13054-018-2157-z · Cited by 416 · see citing works
Qing, G., Zhao, X., Gong, N., Chen, J., Li, X., Gan, Y., Wang, Y., Zhang, Z., Zhang, Y., Guo, W., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12313-3 · Cited by 330 · see citing works
Prehospital antibiotics in the ambulance for sepsis: A multicentre, open label, randomised trial.
Alam, N., Oskam, E., Stassen, P. M., Exter, P. V., van de Ven, P. M., Haak, H. R., Holleman, F., Zanten, A. V., Leeuwen-Nguyen, H. V., Bon, V., et al. (2018) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(17)30469-1 · Cited by 290 · see citing works
Kumar, V. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107087 · Cited by 276 · see citing works
The Clinical Challenge of Sepsis Identification and Monitoring
Vincent, J.-L. (2016) · PLOS Medicine · doi:10.1371/journal.pmed.1002022 · Cited by 259 · see citing works
Organ Dysfunction in Sepsis: An Ominous Trajectory From Infection To Death.
Caraballo, C., & Jaimes, F. A. (2019) · Europe PMC (PubMed Central) · Cited by 244 · see citing works
SepNet Critical Care Trials Group (2016) · Intensive Care Medicine · doi:10.1007/s00134-016-4504-3 · Cited by 242 · see citing works
Neutrophil-to-lymphocyte ratio as a prognostic marker in critically-ill septic patients
Hwang, S. Y., Shin, T. G., Jo, I. J., Jeon, K., Suh, G. Y., Lee, T. R., Yoon, H. J., Cha, W. C., & Sim, M. S. (2016) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2016.10.055 · Cited by 238 · see citing works
Liu, X., Shen, Y., Wang, H., Ge, Q., Fei, A., & Pan, S. (2016) · Mediators of Inflammation · doi:10.1155/2016/8191254 · Cited by 228 · see citing works
Pathophysiology of sepsis-induced myocardial dysfunction
Lv, X., & Wang, H. (2016) · Military Medical Research · doi:10.1186/s40779-016-0099-9 · Cited by 220 · see citing works
Antibiotic resistance: A current epilogue
Dodds, D. R. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.12.005 · Cited by 187 · see citing works
Corylin protects LPS-induced sepsis and attenuates LPS-induced inflammatory response
Hung, Y., Fang, S., Wang, S., Cheng, W., Liu, P., Su, C., Chen, C.-S., Huang, M., Hua, K., Shen, K., et al. (2017) · Scientific Reports · doi:10.1038/srep46299 · Cited by 154 · see citing works
Randolph, A. G., & McCulloh, R. J. (2013) · Virulence · doi:10.4161/viru.27045 · Cited by 153 · see citing works
Pena, O. M., Hancock, D. G., Lyle, N. H., Linder, A., Russell, J. A., Xia, J., Fjell, C. D., Boyd, J. H., & Hancock, R. E. W. (2014) · EBioMedicine · doi:10.1016/j.ebiom.2014.10.003 · Cited by 149 · see citing works
Direct detection and drug-resistance profiling of bacteremias using inertial microfluidics
Hou, H. W., Bhattacharyya, R. P., Hung, D. T., & Han, J. (2015) · Lab on a Chip · doi:10.1039/c5lc00311c · Cited by 143 · see citing works
Peake, S., Bailey, M., Bellomo, R., Cooper, D. J., Higgins, A. M., & Howe, B. D. (2014) · Cited by 142 · see citing works
Průcha, M., Bellingan, G. J., & Zazula, R. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.11.012 · Cited by 132 · see citing works
LiSep LSTM: A Machine Learning Algorithm for Early Detection of Septic Shock
Fagerström, J., Bång, M., Wilhelms, D., & Chew, M. S. (2019) · Scientific Reports · doi:10.1038/s41598-019-51219-4 · Cited by 125 · see citing works
Mouncey, P., Osborn, T. M., Power, G. S., Harrison, D. A., Sadique, Z., Grieve, R., Jahan, R., Tan, J. C., Harvey, S. E., Bell, D., et al. (2015) · Health Technology Assessment · doi:10.3310/hta19970 · Cited by 121 · see citing works
Yan, M. Y., Gustad, L. T., & Nytrø, Ø. (2022) · Journal of the American Medical Informatics Association · doi:10.1093/jamia/ocab236 · Cited by 119 · see citing works
Clements, T. W., Tolonen, M., Ball, C. G., & Kirkpatrick, A. W. (2021) · Scandinavian Journal of Surgery · doi:10.1177/1457496920984078 · Cited by 115 · see citing works
Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages
Ding, X., Kambara, H., Guo, R., Kanneganti, A., Acosta-Zaldívar, M., Li, J., Liu, F., Bei, T., Qi, W., Xie, X., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27034-9 · Cited by 115 · see citing works
Kirkpatrick, A., Coccolini, F., Ansaloni, L., Roberts, D., Tolonen, M., Mckee, J. L., Leppäniemi, A., Faris, P., Doig, C., Catena, F., et al. (2018) · World Journal of Emergency Surgery · doi:10.1186/s13017-018-0183-4 · Cited by 88 · see citing works
Sepsis-induced cardiac dysfunction and β-adrenergic blockade therapy for sepsis
Suzuki, T., Suzuki, Y., Okuda, J., Kurazumi, T., Suhara, T., Ueda, T., Nagata, H., & Morisaki, H. (2017) · Journal of Intensive Care · doi:10.1186/s40560-017-0215-2 · Cited by 109 · see citing works
Single-atom engineering of metal-organic frameworks toward healthcare
Wang, D., & Zhao, Y. (2021) · Chem · doi:10.1016/j.chempr.2021.08.020 · Cited by 107 · see citing works
Philips, C. A., Maiwall, R., Sharma, M. K., Jindal, A., Choudhury, A. K., Kumar, G., Bhardwaj, A., Mitra, L. G., Agarwal, P., & Sarin, S. K. (2021) · Hepatology International · doi:10.1007/s12072-021-10164-z · Cited by 107 · see citing works
Xu, W., Huo, J., Chen, G., Yang, K., Huang, Z., Peng, L., Xu, J., & Jiang, J. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1019502 · Cited by 106 · see citing works
Karampela, Ι., Christodoulatos, G. S., & Dalamaga, Μ. (2019) · Current Obesity Reports · doi:10.1007/s13679-019-00360-2 · Cited by 103 · see citing works
Source control in emergency general surgery: WSES, GAIS, SIS-E, SIS-A guidelines
Coccolini, F., Sartelli, M., Sawyer, R., Rasa, K., Viaggi, B., Abu-Zidan, F., Soreide, K., Hardcastle, T., Gupta, D., Bendinelli, C., et al. (2023) · World Journal of Emergency Surgery · doi:10.1186/s13017-023-00509-4 · Cited by 99 · see citing works
Andriolo, B. N., Andriolo, R. B., Salomão, R., & Atallah, Á. N. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010959.pub2 · Cited by 97 · see citing works
Condor, J. M., Rodrigues, C. E., Moreira, R. D. S., Canale, D., Volpini, R. A., Shimizu, M. H. M., Câmara, N. O. S., Noronha, I. D. L., & Andrade, L. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0138 · Cited by 98 · see citing works
Role of sTREM-1 in predicting mortality of infection: a systematic review and meta-analysis
Su, L., Liu, D., Chai, W., Liu, D., & Long, Y. (2016) · BMJ Open · doi:10.1136/bmjopen-2015-010314 · Cited by 88 · see citing works
Developing predictive models using electronic medical records: challenges and pitfalls.
Paxton, C., Niculescu-Mizil, A., & Saria, S. (2013) · Europe PMC (PubMed Central) · Cited by 88 · see citing works
Oami, T., Watanabe, E., Hatano, M., Sunahara, S., Fujimura, L., Sakamoto, A., Ito, C., Toshimori, K., & Oda, S. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000002016 · Cited by 85 · see citing works
Alapan, Y., Kim, C., Adhikari, A., Gray, K. E., Gürkan-Çavusoglu, E., Little, J. A., & Gurkan, U. A. (2016) · Translational research · doi:10.1016/j.trsl.2016.03.008 · Cited by 76 · see citing works
Platelets and coagulation in infection
Davis, R. P., Miller‐Dorey, S., & Jenne, C. N. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.39 · Cited by 75 · see citing works
He, X., Ai, S., Guo, W., Yang, Y., Wang, Z., Jiang, D., & Xu, X. M. (2018) · Translational research · doi:10.1016/j.trsl.2018.04.006 · Cited by 75 · see citing works
Cellular and viral microRNAs in sepsis: mechanisms of action and clinical applications
Giza, D. E., Fuentes‐Mattei, E., Bullock, M. D., Tudor, Ș., Goblirsch, M. J., Fabbri, M., Lupu, F., Yeung, S. J., Vasilescu, C., & Călin, G. A. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.94 · Cited by 73 · see citing works
van Wyk, F., Khojandi, A., Mohammed, A., Begoli, E., Davis, R. L., & Kamaleswaran, R. (2018) · International Journal of Medical Informatics · doi:10.1016/j.ijmedinf.2018.12.002 · Cited by 66 · see citing works
Sepsis and Septic Shock in Low- and Middle-Income Countries
Stephen, A. H., Montoya, R. L., & Aluisio, A. R. (2020) · Surgical Infections · doi:10.1089/sur.2020.047 · Cited by 68 · see citing works
Frimpong, A., Owusu, E. D. A., Amponsah, J. A., Obeng-Aboagye, E., van der Puije, W., Frempong, A. F., Kusi, K. A., & Ofori, M. F. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.901433 · Cited by 63 · see citing works
Oami, T., Watanabe, E., Hatano, M., Teratake, Y., Fujimura, L., Sakamoto, A., Ito, C., Toshimori, K., Swanson, P. E., & Oda, S. (2017) · Shock · doi:10.1097/shk.0000000000001040 · Cited by 63 · see citing works
Serum 25-Hydroxyvitamin D and the risk of mortality in adult patients with Sepsis: a meta-analysis
Li, Y., & Ding, S. (2020) · BMC Infectious Diseases · doi:10.1186/s12879-020-4879-1 · Cited by 62 · see citing works
Sepsis-related deaths in Brazil: an analysis of the national mortality registry from 2002 to 2010
Taniguchi, L. U., Bierrenbach, A. L., Toscano, C. M., de Schettino, G. P., & Azevedo, L. C. P. (2014) · Critical Care · doi:10.1186/s13054-014-0608-8 · Cited by 59 · see citing works
Duman, A., Aköz, A., Kapçı, M., Türe, M., Örün, S., Karaman, K., & Türkdoğan, K. A. (2016) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2016.06.012 · Cited by 58 · see citing works
Rol, M., Venet, F., Rimmele, T. R., Moucadel, V., Cortez, P., Quéméneur, L., Gardiner, D., Griffiths, A. D., Pachot, A., Textoris, J., et al. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-015734 · Cited by 57 · see citing works
Zhou, X. Q., Liu, D., Su, L., Yao, B., Long, Y., Wang, X., Chai, W., Cui, N., Wang, H., & Xi, R. (2017) · Critical Care · doi:10.1186/s13054-017-1617-1 · Cited by 57 · see citing works
Di, S., Wang, Z., Hu, W., Yan, X., Ma, Z., Li, X., Li, W., & Gao, J. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00162 · Cited by 56 · see citing works
Gasdermin D (GSDMD) as a new target for the treatment of infection
Pandeya, A., Li, L., Li, Z., & Wei, Y. (2019) · MedChemComm · doi:10.1039/c9md00059c · Cited by 55 · see citing works
From the Closed Or Open after Laparotomy (COOL) for Source Control in Severe Complicated Intra-Abdominal Sepsis Investigators, Tolonen, M., Coccolini, F., Ansaloni, L., Sartelli, M., Roberts, D. J., McKee, J. L., Leppäniemi, A. K., Doig, C. J., Catena, F., et al. (2018) · World Journal of Emergency Surgery · doi:10.1186/s13017-018-0177-2 · Cited by 54 · see citing works
Celastrol aggravates LPS-induced inflammation and injuries of liver and kidney in mice.
Wu, M., Chen, W., Yu, X., Ding, D., Zhang, W., Hu, H., Xu, M., Meng, X., Zhang, X., Zhang, Y., et al. (2018) · Europe PMC (PubMed Central) · Cited by 53 · see citing works
Hammond, N. E., Finfer, S. R., Li, Q., Taylor, C. B., Cohen, J., Arabi, Y. M., Bellomo, R., Billot, L., Harward, M. L., Joyce, C., et al. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06169-1 · Cited by 50 · see citing works
Evaluation of the Molecular Mechanisms of Sepsis Using Proteomics
He, M., Chen, S., & Ding, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.733537 · Cited by 49 · see citing works
Efficacy of IVIG therapy for patients with sepsis: a systematic review and meta-analysis
Pan, B., Sun, P., Pei, R., Lin, F., & Cao, H. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04592-8 · Cited by 49 · see citing works
Phenol-Soluble Modulin Toxins of Staphylococcus haemolyticus
Da, F., Joo, H., Cheung, G. Y. C., Villaruz, A. E., Rohde, H., Luo, X., & Otto, M. J. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00206 · Cited by 48 · see citing works
Use of explicit ICD9-CM codes to identify adult severe sepsis: impacts on epidemiological estimates
Bouza, C., Lopez-Cuadrado, T., & Amate-Blanco, J. M. (2016) · Critical Care · doi:10.1186/s13054-016-1497-9 · Cited by 47 · see citing works
Adult sepsis – A nationwide study of trends and outcomes in a population of 23 million people
Lee, C., Yo, C., Lee, M.-T. G., Tsai, K., Lee, S.-H., Chen, Y., Lee, W.-C., Hsu, T., Lee, S.-H., & Chang, S.-S. (2017) · Journal of Infection · doi:10.1016/j.jinf.2017.08.012 · Cited by 47 · see citing works
Anti-inflammatory and anti-bacterial effects of iron chelation in experimental sepsis
Islam, S., Jarosch, S., Zhou, J., Parquet, M. D. C., Toguri, J. T., Colp, P., Holbein, B. E., & Lehmann, C. (2015) · Journal of Surgical Research · doi:10.1016/j.jss.2015.07.001 · Cited by 44 · see citing works
Prediction of Sepsis and In-Hospital Mortality Using Electronic Health Records
Tansakul, V., Li, X., Koszalinski, R. S., Paiva, W., & Khojandi, A. (2018) · Methods of Information in Medicine · doi:10.3414/me18-01-0014 · Cited by 44 · see citing works
Padhi, R. K., Kabi, S., Panda, B. N., & Jagati, S. (2018) · International Journal of Critical Illness and Injury Science · doi:10.4103/ijciis.ijciis_29_17 · Cited by 45 · see citing works
Prospects of coupled iron-based nanostructures in preclinical antibacterial therapy
Han, J., Zeng, S., Chen, Y., Li, H., & Yoon, J. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114672 · Cited by 42 · see citing works
A survey of sepsis knowledge among Canadian emergency department registered nurses
Storozuk, S. A., MacLeod, M., Freeman, S., & Banner, D. (2019) · Australasian Emergency Care · doi:10.1016/j.auec.2019.01.007 · Cited by 42 · see citing works
Lanspa, M. J., Burk, R. E., Wilson, E. L., Hirshberg, E. L., Grissom, C. K., & Brown, S. M. (2018) · Journal of Intensive Care · doi:10.1186/s40560-018-0319-3 · Cited by 42 · see citing works
RNA m6A methylation regulators in sepsis
Zhu, L., Zhang, H., Zhang, X., & Xia, L. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04841-w · Cited by 40 · see citing works
Mulatu, H. A., Bayisa, T., Worku, Y., Lazarus, J. J., Woldeyes, E., Bacha, D. G., Taye, B., Nigussie, M., Gebeyehu, H., & Kebede, A. (2020) · African Journal of Emergency Medicine · doi:10.1016/j.afjem.2020.10.001 · Cited by 39 · see citing works
Sepsis, severe sepsis, and septic shock: A review of the literature
Tupchong, K., Koyfman, A., & Foran, M. P. (2014) · African Journal of Emergency Medicine · doi:10.1016/j.afjem.2014.05.004 · Cited by 39 · see citing works
Bao, R., Shui, X., Hou, J., Li, J., Deng, X., Zhu, X., & Yang, T. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2679 · Cited by 38 · see citing works
Chen, K., Lee, S.-H., Kok, L.-C., Ishdorj, T.-O., Chang, H., & Tseng, F. (2021) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2021.113740 · Cited by 38 · see citing works
Biomarkers for Sepsis: A Review with Special Attention to India
Nelson, G. E., Mave, V., & Gupta, A. (2014) · BioMed Research International · doi:10.1155/2014/264351 · Cited by 37 · see citing works
Liu, Z., Shi, Q., Liu, J., Abdel-Razek, O. A., Xu, Y., Cooney, R. N., & Wang, G. (2015) · Scientific Reports · doi:10.1038/srep17798 · Cited by 37 · see citing works
Liu, X., Shen, Y., Li, Z., Fei, A., Wang, H., Ge, Q., & Pan, S. (2015) · BMC Anesthesiology · doi:10.1186/s12871-016-0212-3 · Cited by 37 · see citing works
McColl, T., Gatien, M., Calder, L. A., Yadav, K., Tam, R., Ong, M., Taljaard, M., & Stiell, I. G. (2016) · Canadian Journal of Emergency Medicine · doi:10.1017/cem.2016.351 · Cited by 37 · see citing works
Kortz, T. B., Axelrod, D. M., Chisti, M. J., & Kache, S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181160 · Cited by 35 · see citing works
Green propolis extract attenuates acute kidney injury and lung injury in a rat model of sepsis
Silveira, M. A. D., Capcha, J. M. C., Sanches, T. R., Moreira, R. D. S., Garnica, M. R., Shimizu, M. H. M., Berretta, A. A., Teles, F., Noronha, I. L., & Andrade, L. (2021) · Scientific Reports · doi:10.1038/s41598-021-85124-6 · Cited by 35 · see citing works
Riquelme, S. A., Bueno, S. M., & Kalergis, A. M. (2014) · Immunology · doi:10.1111/imm.12375 · Cited by 34 · see citing works
Herrmann, I. K., Bertazzo, S., O'Callaghan, D. J. P., Schlegel, A. A., Kallepitis, C., Antcliffe, D. B., Gordon, A. C., & Stevens, M. M. (2015) · Nanoscale · doi:10.1039/c5nr01851j · Cited by 33 · see citing works
She, H., Zhu, Y., Deng, H., Kuang, L., He, F., Zhang, Z., Duan, C., Ye, J., Zhang, J., Liu, L., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.636327 · Cited by 33 · see citing works
Tillmann, B. W., & Wunsch, H. (2017) · Critical Care Clinics · doi:10.1016/j.ccc.2017.08.001 · Cited by 32 · see citing works
Identification of key pathogenic genes of sepsis based on the Gene Expression Omnibus database
Lu, X., Xue, L., Sun, W., Ye, J., Zhu, Z., & Mei, H. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.8258 · Cited by 32 · see citing works
Combined CD25, CD64, and CD69 biomarker panel for flow cytometry diagnosis of sepsis
Zhou, Y., Zhang, Y., Johnson, A., Venable, A., Griswold, J., & Pappas, D. (2018) · Talanta · doi:10.1016/j.talanta.2018.08.058 · Cited by 32 · see citing works
Rusconi, A. M., Bossi, I. E., Lampard, J. G., Szava‐Kovats, M., Bellone, A., & Lang, E. (2015) · Internal and Emergency Medicine · doi:10.1007/s11739-015-1248-y · Cited by 31 · see citing works
Hemodynamic monitoring and management of pediatric septic shock
Lee, E., Wu, H., Chan, O., Lin, J., & Hsia, S. (2021) · Biomedical Journal · doi:10.1016/j.bj.2021.10.004 · Cited by 31 · see citing works
Hayashida, K., Kondo, Y., Hara, Y., Aihara, M., & Yamakawa, K. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-014305 · Cited by 31 · see citing works
Hyperphosphatemia rather than hypophosphatemia indicates a poor prognosis in patients with sepsis
Wang, H., Zhang, L., Liao, W., Huang, J., Xu, J., Yang, J., Chen, C., & He, Z. (2021) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2021.01.016 · Cited by 31 · see citing works
Community-onset sepsis and its public health burden: a systematic review
Tsertsvadze, A., Royle, P., Seedat, F., Cooper, J., Crosby, R., & McCarthy, N. D. (2016) · Systematic Reviews · doi:10.1186/s13643-016-0243-3 · Cited by 31 · see citing works
Lee, E., Hsia, S., Lin, J., Chan, O., Lee, J., Lin, C.-Y., & Wu, H. (2017) · BioMed Research International · doi:10.1155/2017/3613475 · Cited by 30 · see citing works
Ahn, S. Y., Maeng, Y., Kim, Y. R., Choe, Y. H., Hwang, H. S., & Hyun, Y. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-1559-4 · Cited by 30 · see citing works
How Can We Estimate Sepsis Incidence and Mortality?
Gobatto, A. L. N., Besen, B. A. M. P., & Azevedo, L. C. P. (2016) · Shock · doi:10.1097/shk.0000000000000703 · Cited by 30 · see citing works
Lu, Y. W., Zhang, H., Teng, F., Xia, W.-J., Sun, G., & Wen, A. (2016) · Journal of Intensive Care Medicine · doi:10.1177/0885066616671710 · Cited by 30 · see citing works
Li, J., Ning, B., Wang, Y., Li, B., Qian, J., Ren, H. W., Zhang, J., & Hu, X. (2019) · Medicine · doi:10.1097/md.0000000000015070 · Cited by 30 · see citing works
Efficacy Study on Interactive Mixed Reality (IMR) Software with Sepsis Prevention Medical Education
Sankaran, N. K., Nisar, H., Zhang, J., Formella, K. T., Amos, J. R., Barker, L. T., Vozenilek, J. A., LaValle, S. M., & Kesavadas, T. (2019) · IEEE Conference on Virtual Reality and 3D User Interfaces (VR) · doi:10.1109/vr.2019.8798089 · Cited by 29 · see citing works
Andini, N., Hu, A., Zhou, L., Cogill, S., Wang, T., Wittwer, C. T., & Yang, S. S. (2018) · Clinical Chemistry · doi:10.1373/clinchem.2018.290189 · Cited by 29 · see citing works
Zhang, Y., Zhou, Y., Li, W., Lyons, V., Johnson, A., Venable, A., Griswold, J., & Pappas, D. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.7b05305 · Cited by 28 · see citing works
Shao, W., Yu, D., Zhang, W., & Wang, X. (2018) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000001904 · Cited by 28 · see citing works
Higgins, A. M., Peake, S., Bellomo, R., Cooper, D. J., Delaney, A. P., Harris, A., Howe, B. D., Nichol, A., Webb, S. A. R., & Williams, P. J. (2019) · Critical Care Medicine · doi:10.1097/ccm.0000000000003762 · Cited by 28 · see citing works
- Authors
- Jawad, I., Lukšić, I., & Rafnsson, S. B.
- Affiliations
- University of Edinburgh (GB)
- Venue
- Journal of Global Health
- Publisher
- International Global Health Society
- Published
- 2012-06
- Volume
- 2
- Issue
- 1
- Pages
- 010404-010404
- ISSN
- 2047-2978 (ISSN-L)
- 2047-2986
- PMC
- PMC3484761
- OpenAlex
- W4237666362
- Cited by
- 389
- References
- 24
- Citations by year
- 2026: 2 · 2025: 16 · 2024: 29 · 2023: 26 · 2022: 24 · 2021: 31 · 2020: 53 · 2019: 34 · 2018: 37 · 2017: 32 · 2016: 44 · 2015: 28 · 2014: 24 · 2013: 9
- FWCI
- 14.55
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Journal of Global Health (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Keywords
- sepsis, severe sepsis, septic shock, global burden of disease, incidence, prevalence, mortality, case fatality rate, data gaps, developing countries, sepsis epidemiology, sepsis definitions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
