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Cited by 496

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Future Research Directions in Acute Lung Injury: Summary of a National Heart, Lung, and Blood Institute Working Group

Matthay, Michael A., Zimmerman, Guy A., Esmon, Charles, Bhattacharya, Jahar, Coller, Barry, Doerschuk, Claire M., Floros, Joanna, Gimbrone, Michael A., Hoffman, Eric, Hubmayr, Rolf D., Leppert, Mark, Matalon, Sadis, Munford, Robert, Parsons, Polly, Slutsky, Arthur S., Tracey, Kevin J., Ward, Peter, Gail, Dorothy B., Harabin, Andrea L.·2003·American Journal of Respiratory and Critical Care Medicine

Abstract

Acute lung injury (ALI) and its more severe form, the acute respiratory distress syndrome (ARDS), are syndromes of acute respiratory failure that result from acute pulmonary edema and inflammation. The development of ALI/ARDS is associated with several clinical disorders including direct pulmonary injury from pneumonia and aspiration as well as indirect pulmonary injury from trauma, sepsis, and other disorders such as acute pancreatitis and drug overdose. Although mortality from ALI/ARDS has decreased in the last decade, it remains high. Despite two major advances in treatment, low VT ventilation for ALI/ARDS and activated protein C for severe sepsis (the leading cause of ALI/ARDS), additional research is needed to develop specific treatments and improve understanding of the pathogenesis of these syndromes. The NHLBI convened a working group to develop specific recommendations for future ALI/ARDS research. Improved understanding of disease heterogeneity through use of evolving biologic, genomic, and genetic approaches should provide major new insights into pathogenesis of ALI. Cellular and molecular methods combined with animal and clinical studies should lead to further progress in the detection and treatment of this complex disease.

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Metadata

Authors
Matthay, M. A., Zimmerman, G. A., Esmon, C., Bhattacharya, J., Coller, B., Doerschuk, C. M., Floros, J., Gimbrone, M. A., Hoffman, E., Hubmayr, R. D., Leppert, M., Matalon, S., Munford, R., Parsons, P., Slutsky, A. S., Tracey, K. J., Ward, P., Gail, D. B., & Harabin, A. L.
Venue
American Journal of Respiratory and Critical Care Medicine
Published
2003-04-01
Volume
167
Issue
7
Pages
1027-1035
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
OpenAlex
W1892829132
Cited by
496
References
6
FWCI
22.96
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Future Research Directions in Acute Lung Injury: Summary of a National Heart, Lung, and Blood Institute Working Group. https://app.cochat.ai/papers/10.1164/rccm.200208-966ws
The paper
Matthay, M. A., Zimmerman, G. A., Esmon, C., Bhattacharya, J., Coller, B., Doerschuk, C. M., Floros, J., Gimbrone, M. A., Hoffman, E., Hubmayr, R. D., Leppert, M., Matalon, S., Munford, R., Parsons, P., Slutsky, A. S., Tracey, K. J., Ward, P., Gail, D. B., & Harabin, A. L. (2003). Future Research Directions in Acute Lung Injury: Summary of a National Heart, Lung, and Blood Institute Working Group. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200208-966ws

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.