The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Sequential recruitment of neutrophils into lung and bronchoalveolar lavage fluid in LPS-induced acute lung injury
Abstract
Infiltration of activated neutrophils [polymorphonuclear leukocytes (PMN)] into the lung is an important component of the inflammatory response in acute lung injury. The signals required to direct PMN into the different compartments of the lung have not been fully elucidated. In a murine model of LPS-induced lung injury, we investigated the sequential recruitment of PMN into the pulmonary vasculature, lung interstitium, and alveolar space. Mice were exposed to aerosolized LPS and bronchoalveolar lavage fluid (BAL), and lungs were harvested at different time points. We developed a flow cytometry-based technique to assess in vivo trafficking of PMN in the intravascular and extravascular lung compartments. Aerosolized LPS induced consistent PMN migration into all lung compartments. We found that sequestration in the pulmonary vasculature occurred within the first hour. Transendothelial migration into the interstitial space started 1 h after LPS exposure and increased continuously until a plateau was reached between 12 and 24 h. Transepithelial migration into the alveolar air space was delayed, as the first PMN did not appear until 2 h after LPS, reaching a peak at 24 h. Transendothelial migration and transepithelial migration were inhibited by pertussis toxin, indicating involvement of Gαi-coupled receptors. These findings confirm LPS-induced migration of PMN into the lung. For the first time, distinct transmigration steps into the different lung compartments are characterized in vivo.
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Cites
Neutrophils and acute lung injury
Abraham, E. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000057843.47705.e8 · Cited by 850
Li, Q., Park, P. W., Wilson, C. L., & Parks, W. C. (2002) · Cell · doi:10.1016/s0092-8674(02)01079-6 · Cited by 752
Matthay, M. A., Zimmerman, G. A., Esmon, C., Bhattacharya, J., Coller, B., Doerschuk, C. M., Floros, J., Gimbrone, M. A., Hoffman, E., Hubmayr, R. D., et al. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200208-966ws · Cited by 496
Protective Effects of Sphingosine 1-Phosphate in Murine Endotoxin-induced Inflammatory Lung Injury
Peng, X., Hassoun, P. M., Sammani, S., McVerry, B. J., Burne, M. J., Rabb, H., Pearse, D., Tuder, R. M., & Garcia, J. G. N. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200309-1258oc · Cited by 495
Miller, E. J., Cohen, A. B., Nagao, S., Griffith, D., Maunder, R. J., Martin, T. R., Weiner-Kronish, J. P., Sticherling, M., Christophers, E., & Matthay, M. A. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/146.2.427 · Cited by 472
Andonegui, G., Bonder, C. S., Green, F., Mullaly, S. C., Zbytnuik, L., Raharjo, E., & Kubes, P. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16510 · Cited by 408
Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury
Belperio, J. A., Keane, M. P., Burdick, M. D., Londhe, V. A., Xue, Y., Li, K., Phillips, R. J., & Strieter, R. M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15849 · Cited by 402
Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury
Belperio, J. A., Keane, M. P., Burdick, M. D., Londhe, V., Xue, Y. Y., Li, K., Phillips, R. J., & Strieter, R. M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215849 · Cited by 366
Kina, T., Ikuta, K., Takayama, E., Wada, K., Majumdar, A. S., Weissman, I. L., & Katsura, Y. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.02037.x · Cited by 350
Yamada, M., Kubo, H., Kobayashi, S., Ishizawa, K., Numasaki, M., Ueda, S., Suzuki, T., & Sasaki, H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.2.1266 · Cited by 340
Cited by
Intravascular staining for discrimination of vascular and tissue leukocytes
Anderson, K. G., Mayer-Barber, K., Sung, H., Beura, L., James, B. R., Taylor, J. J., Qunaj, L., Griffith, T. S., Vezys, V., Barber, D. L., et al. (2014) · Nature Protocols · doi:10.1038/nprot.2014.005 · Cited by 812
Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation
Zarbock, A., Singbartl, K., & Ley, K. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29499 · Cited by 601
Self-citationHepatic platelet and leukocyte adherence during endotoxemia
Croner, R. S., Hoerer, E., Kulu, Y., Hackert, T., Gebhard, M.-M., Herfarth, C., & Klar, E. (2006) · Critical Care · doi:10.1186/cc3968 · Cited by 275
Chong, S. Z., Evrard, M., Devi, S., Chen, J., Lim, J. Y., See, P., Zhang, Y., Adrover, J. M., Lee, B., Tan, L., et al. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20160800 · Cited by 142
Kambas, K., Markiewski, M. M., Pneumatikos, I. A., Rafail, S. S., Theodorou, V., Konstantonis, D., Kourtzelis, I., Doumas, M. N., Magotti, P., DeAngelis, R. A., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.11.7368 · Cited by 127
Metadata
- Authors
- Reutershan, J., Basit, A., Galkina, E. V., & Ley, K.
- Venue
- American Journal of Physiology-Lung Cellular and Molecular Physiology
- Publisher
- American Physiological Society
- Published
- 2005-11
- Volume
- 289
- Issue
- 5
- Pages
- L807-L815
- ISSN
- 1040-0605 (ISSN-L)
- 1522-1504
- OpenAlex
- W2098784648
- Cited by
- 309
- References
- 37
- FWCI
- 8.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Reutershan, J., Basit, A., Galkina, E. V., & Ley, K. (2005). Sequential recruitment of neutrophils into lung and bronchoalveolar lavage fluid in LPS-induced acute lung injury. American Journal of Physiology-Lung Cellular and Molecular Physiology. https://doi.org/10.1152/ajplung.00477.2004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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