The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cigarette Smoking Impairs the Therapeutic Response to Oral Corticosteroids in Chronic Asthma
Abstract
The study was designed to assess the effect of cigarette smoking on the therapeutic response to oral corticosteroids in chronic stable asthma. We performed a randomized, placebo-controlled, crossover study with prednisolone (40 mg daily) or placebo for 2 weeks in smokers with asthma, ex-smokers with asthma, and never-smokers with asthma. All subjects had reversibility in FEV1 after nebulized albuterol of 15% or more and a mean postbronchodilator FEV1% predicted of more than 80%. Efficacy was assessed using FEV1, daily PEF, and an asthma control score. There was a significant improvement after oral prednisolone compared with placebo in FEV1, ml (mean difference, 237; 95% confidence intervals, 43, 231; p = 0.019), morning PEF L/m (mean difference, 36.8; 95% confidence intervals (CI), 11, 62; p = 0.006), and asthma control score (mean difference, -0.72; 95% CI, -1.2, -0.3; p = 0.004) in never-smokers with asthma but no change in smokers with asthma (mean differences of 47, 6.5, and -0.05 with p values of 0.605, 0.47, and 0.865, respectively). Ex-smokers with asthma had a significant improvement in morning and night PEF (mean difference, 29.1; CI, 2.3, 56; p = 0.04 and 52.4; CI, 26, 79; p = 0.003, respectively), but not in FEV1 or asthma control score. We conclude that active smoking impairs the efficacy of short-term oral corticosteroid treatment in chronic asthma.
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Cites
Webster, J. C., Oakley, R. H., Jewell, C. M., & Cidlowski, J. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121455098 · Cited by 482
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Hasler, G., Gergen, P. J., Kleinbaum, D. G., Ajdacic, V., Gamma, A., Eich, D., Rössler, W., & Angst, J. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200412-1669oc · Cited by 248
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Lavoie, K. L., Cartier, A., Labrecque, M., Bacon, S. L., Lemière, C., Malo, J.-L., Lacoste, G., Barone, S., Verrier, P., & Ditto, B. (2005) · Respiratory Medicine · doi:10.1016/j.rmed.2005.03.003 · Cited by 201
Asthma and cigarette smoking: a review of the empirical literature
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Del Giacco, S. R., Bakirtas, A., Bel, E., Custovic, A., Diamant, Z., Hamelmann, E., Heffler, E., Kalayci, Ö., Saglani, S., Sergejeva, S., et al. (2017) · Allergy · doi:10.1111/all.13072 · Cited by 130
“Cigarette smoking itself may influence asthma, as it accelerates lung function decline (117), impairs the response to CS (both inhaled and oral) (118), increases airway oxidative stress (119), perpetuates symptoms despite of treatment (120) and induces the change of inflammatory phenotypes into more aggressive ones (1…”
BackgroundHigh prevalence of severe asthma in a large random population study
Mincheva, R., Ekerljung, L., Bossios, A., Lundbäck, B., & Lötvall, J. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.07.047 · Cited by 37
Pressler, T. R., & Kaizar, E. E. (2013) · Statistics in Medicine · doi:10.1002/sim.5802 · Cited by 32
Metadata
- Authors
- Chaudhuri, R., Livingston, E., McMahon, A. D., Thomson, L., Borland, W., & Thomson, N. C.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-12-01
- Volume
- 168
- Issue
- 11
- Pages
- 1308-1311
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2165465489
- Cited by
- 470
- References
- 1
- FWCI
- 15.38
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
