The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Diagnosing Asthma: Comparisons between Exhaled Nitric Oxide Measurements and Conventional Tests
Abstract
International guidelines recommend a range of clinical tests to confirm the diagnosis of asthma. These focus largely on identifying variable airflow obstruction and responses to bronchodilator or corticosteroid. More recently, exhaled nitric oxide (FE(NO)) measurements and induced sputum analysis to assess airway inflammation have been highlighted. However, to date, no systematic comparisons to confirm the diagnostic utility of each of these methods have been performed. To do so, we investigated 47 consecutive patients with symptoms suggestive of asthma, using a comprehensive fixed-sequence series of diagnostic tests. Sensitivities and specificities were obtained for peak flow measurements, spirometry, and changes in these parameters after a trial of steroid. Comparisons were made against FE(NO) and sputum cell counts. Sensitivities for each of the conventional tests (0-47%) were lower than for FE(NO) (88%) and sputum eosinophils (86%). Overall, the diagnostic accuracy when using FE(NO) and sputum eosinophils was significantly greater. Results for conventional tests were not improved, using a trial of steroid. We conclude that FE(NO) measurements and induced sputum analysis are superior to conventional approaches, with exhaled nitric oxide being most advantageous because the test is quick and easy to perform.
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Cites
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Lung Function Testing: Selection of Reference Values and Interpretative Strategies
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Increased nitric oxide in exhaled air of asthmatic patients
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Lung Function Testing: Selectionof reference Values and Interpretative Strategies
Miller, A. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/146.5_pt_1.1368b · Cited by 1,426
Mucosal Inflammation in Asthma
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Increased amount of nitric oxide in exhaled air of asthmatics
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Cited by
(2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200406-710st · Cited by 3,203
Dweik, R. A., Boggs, P. B., Erzurum, S. C., Irvin, C. G., Leigh, M. W., Lundberg, J. O., Olin, A.-C., Plummer, A. L., & Taylor, D. R. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.9120-11st · Cited by 2,539
Self-citationExhaled nitric oxide measurements: clinical application and interpretation
Taylor, D. R., Pijnenburg, M. W., Smith, A. D., & Jongste, J. C. D. (2006) · Thorax · doi:10.1136/thx.2005.056093 · Cited by 507
Self-citationA daily SMS reminder increases adherence to asthma treatment: A three-month follow-up study
Strandbygaard, U., Thomsen, S. F., & Backer, V. (2010) · Respiratory Medicine · doi:10.1016/j.rmed.2009.10.003 · Cited by 295
Exhaled markers of inflammatory lung diseases: ready for routine monitoring?
Kharitonov, S. (2004) · Swiss Medical Weekly · doi:10.4414/smw.2004.10411 · Cited by 74
Metadata
- Authors
- Smith, A. D., Cowan, J. O., Filsell, S., McLachlan, C., Monti-Sheehan, G., Jackson, P., & Taylor, D. R.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-02-15
- Volume
- 169
- Issue
- 4
- Pages
- 473-478
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2038777547
- Cited by
- 469
- References
- 31
- FWCI
- 11.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- Smith, A. D., Cowan, J. O., Filsell, S., McLachlan, C., Monti-Sheehan, G., Jackson, P., & Taylor, D. R. (2004). Diagnosing Asthma: Comparisons between Exhaled Nitric Oxide Measurements and Conventional Tests. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200310-1376oc
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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