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Specific Detection of Tuberculosis Infection: An Interferon-γ–based Assay Using New Antigens
Abstract
The tuberculin skin test for immunologic diagnosis of Mycobacterium tuberculosis infection has many limitations, including being confounded by bacillus Calmette-Guérin (BCG) vaccination or exposure to nontuberculous mycobacteria. M. tuberculosis-specific antigens that are absent from BCG and most nontuberculous mycobacteria have been identified. We examined the use of two of these antigens, CFP-10 and ESAT-6, in a whole blood IFN-gamma assay as a diagnostic test for tuberculosis in BCG-vaccinated individuals. Because of the lack of an accurate standard with which to compare new tests for M. tuberculosis infection, specificity of the whole blood IFN-gamma assay was estimated on the basis of data from people with no identified risk for M. tuberculosis exposure (216 BCG-vaccinated Japanese adults) and sensitivity was estimated on the basis of data from 118 patients with culture-confirmed M. tuberculosis infection who had received less than 1 week of treatment. Using a combination of CFP-10 and ESAT-6 responses, the specificity of the test for the low-risk group was 98.1% and the sensitivity for patients with M. tuberculosis infection was 89.0%. The results demonstrate that the whole blood IFN-gamma assay using CFP-10 and ESAT-6 was highly specific and sensitive for M. tuberculosis infection and was unaffected by BCG vaccination status.
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Citations
Cited by
Interferon-γ assays in the immunodiagnosis of tuberculosis: a systematic review
Pai, M., Riley, L. W., & Colford, J. M. (2004) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(04)01206-x · Cited by 913
A systematic review of rapid diagnostic tests for the detection of tuberculosis infection
Dinnes, J., Deeks, J., Kunst, H., Gibson, A., Cummins, E., Waugh, N., Drobniewski, F., & Lalvani, A. (2007) · Health Technology Assessment · doi:10.3310/hta11030 · Cited by 666
ESAT-6 proteins: protective antigens and virulence factors?
Brodin, P., Rosenkrands, I., Andersen, P., Cole, S. T., & Brosch, R. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.09.007 · Cited by 312
Comparison of two commercial interferon-γ assays for diagnosing Mycobacterium tuberculosis infection
Lee, J. Y., Choi, H. J., Park, I.-N., Hong, S.-B., Oh, Y.-M., Lim, C.-M., Lee, S. D., Koh, Y., Kim, W. S., Kim, D. S., et al. (2006) · European Respiratory Journal · doi:10.1183/09031936.06.00016906 · Cited by 257
Metadata
- Authors
- Mori, T., Sakatani, M., Yamagishi, F., Takashima, T., Kawabe, Y., Nagao, K., Shigeto, E., Harada, N., Mitarai, S., Okada, M., Suzuki, K., Inoue, Y., Tsuyuguchi, K., Sasaki, Y., Mazurek, G. H., & Tsuyuguchi, I.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-07-01
- Volume
- 170
- Issue
- 1
- Pages
- 59-64
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2102777134
- Cited by
- 657
- References
- 0
- FWCI
- 37.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mori, T., Sakatani, M., Yamagishi, F., Takashima, T., Kawabe, Y., Nagao, K., Shigeto, E., Harada, N., Mitarai, S., Okada, M., Suzuki, K., Inoue, Y., Tsuyuguchi, K., Sasaki, Y., Mazurek, G. H., & Tsuyuguchi, I. (2004). Specific Detection of Tuberculosis Infection: An Interferon-γ–based Assay Using New Antigens. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200402-179oc
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