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Comparison of Tuberculin Skin Test and New Specific Blood Test in Tuberculosis Contacts
Abstract
The tuberculin skin test used to detect latent Mycobacterium tuberculosis infection has many drawbacks, and a new diagnostic test for latent tuberculosis (QuantiFERON-TB [QTF-TB]) has recently been introduced. This test measures the production of IFN-gamma in whole blood upon stimulation with purified protein derivative (PPD). The QTF-TB test addresses the operational problems with the tuberculin skin test, but, as the test is based on PPD, it still has a low specificity in populations vaccinated with the Bacille Calmette-Guérin (BCG) vaccine. We have modified the test to include the antigens ESAT-6 and CFP-10, which are not present in BCG vaccine strains or the vast majority of nontuberculous mycobacteria. This test was used to detect infection in contacts in a tuberculosis outbreak at a Danish high school. The majority of the contacts were BCG-unvaccinated, which allowed a direct comparison of the skin test and the novel blood test in individuals whose skin test was not confounded by vaccination. An excellent agreement between the two tests was found (94%, kappa value 0.866), and in contrast to the blood test based on PPD, the novel blood test was not influenced by the vaccination status of the subjects tested.
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Cited by
Menzies, D., Pai, M., & Comstock, G. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-5-200703060-00006 · Cited by 984
Interferon-γ assays in the immunodiagnosis of tuberculosis: a systematic review
Pai, M., Riley, L. W., & Colford, J. M. (2004) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(04)01206-x · Cited by 913
Allergy Diagnostic Testing: An Updated Practice Parameter
Bernstein, I. L., Li, J. T., Bernstein, D. I., Hamilton, R., Spector, S. L., Tan, R., Sicherer, S., Golden, D. B. K., Khan, D. A., Nicklas, R. A., et al. (2008) · Annals of Allergy, Asthma & Immunology · doi:10.1016/s1081-1206(10)60305-5 · Cited by 723
Mack, U., Migliori, G. B., Sester, M., Rieder, H. L., Ehlers, S., Goletti, D., Bossink, A., Magdorf, K., Hölscher, C., Kampmann, B., et al. (2009) · European Respiratory Journal · doi:10.1183/09031936.00120908 · Cited by 591
Diel, R., Loddenkemper, R., Meywald-Walter, K., Niemann, S., & Nienhaus, A. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200711-1613oc · Cited by 351
Metadata
- Authors
- Brock, I., Weldingh, K., Lillebaek, T., Follmann, F., & Andersen, P.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-07-01
- Volume
- 170
- Issue
- 1
- Pages
- 65-69
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2148140865
- Cited by
- 333
- References
- 0
- FWCI
- 25.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Brock, I., Weldingh, K., Lillebaek, T., Follmann, F., & Andersen, P. (2004). Comparison of Tuberculin Skin Test and New Specific Blood Test in Tuberculosis Contacts. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200402-232oc
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