The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Predictive Value of a Whole Blood IFN-γ Assay for the Development of Active Tuberculosis Disease after Recent Infection with Mycobacterium tuberculosis
Abstract
RATIONALE: Numerous studies have been published on the new Mycobacterium tuberculosis (MTB)-specific IFN-gamma release assays. However, their prognostic value for progression from latent tuberculosis infection (LTBI) to active TB has yet to be established. OBJECTIVES: To compare the QuantiFERON-TB Gold In-Tube assay (QFT) with the tuberculin skin test (TST) in recently exposed close contacts of active TB cases with respect to their development of TB disease within 2 years. METHODS: Close contacts (n = 601) of MTB-positive source cases underwent both TST and QFT testing and were subsequently observed for 103 (+/-13.5) weeks. Risk factors for MTB infection were evaluated by multivariate analysis. MEASUREMENTS AND MAIN RESULTS: For the TST, 40.4% (243/601) of contacts were positive at a 5-mm cutoff, whereas only 66 (11%) were QFT positive. QFT positivity, but not TST, was associated with exposure time (P < 0.0001). Six contacts progressed to TB disease within the 2-year follow-up. All were QFT positive and had declined preventive treatment, equating to a progression rate of 14.6% (6/41) among those who were QFT positive. The progression rate for untreated TST-positive subjects was significantly lower (P < 0.003), at 2.3% (5 of 219), and one subject who progressed was TST negative. CONCLUSIONS: Results suggest that QFT is a more accurate indicator of the presence of LTBI than the TST and provides at least the same sensitivity for detecting those who will progress to active TB. The high rate of progression to active TB of those who are QFT positive (14.6%), which is far greater than the 2.3% found for those who are TST positive, has health and economic implications for enhanced TB control, particularly if this higher progression rate is seen in studies of other at-risk populations.
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Specific Detection of Tuberculosis Infection: An Interferon-γ–based Assay Using New Antigens
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Comparison of Tuberculin Skin Test and New Specific Blood Test in Tuberculosis Contacts
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Proportion of tuberculosis transmission that takes place in households in a high-incidence area
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Contact investigation for tuberculosis: a systematic review and meta-analysis
Fox, G. J., Barry, S. E., Britton, W. J., & Marks, G. B. (2013) · European Respiratory Journal · doi:10.1183/09031936.00070812 · Cited by 709
Mack, U., Migliori, G. B., Sester, M., Rieder, H. L., Ehlers, S., Goletti, D., Bossink, A., Magdorf, K., Hölscher, C., Kampmann, B., et al. (2009) · European Respiratory Journal · doi:10.1183/09031936.00120908 · Cited by 591
Self-citationThe global prevalence of latent tuberculosis: A systematic review and meta-analysis
Cohen, A., Mathiasen, V. D., Schön, T., & Wejse, C. (2019) · European Respiratory Journal · doi:10.1183/13993003.00655-2019 · Cited by 547
Solovic, I., Sester, M., Gomez-Reino, J. J., Rieder, H. L., Ehlers, S., Milburn, H. J., Kampmann, B., Hellmich, B., Groves, R., Schreiber, S., et al. (2010) · European Respiratory Journal · doi:10.1183/09031936.00028510 · Cited by 527
Self-citationImmunological biomarkers of tuberculosis
Walzl, G., Ronacher, K., Hanekom, W., Scriba, T. J., & Zumla, A. (2011) · Nature Reviews Immunology · doi:10.1038/nri2960 · Cited by 477
Metadata
- Authors
- Diel, R., Loddenkemper, R., Meywald-Walter, K., Niemann, S., & Nienhaus, A.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-05-15
- Volume
- 177
- Issue
- 10
- Pages
- 1164-1170
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2147180609
- Cited by
- 351
- References
- 16
- FWCI
- 39.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- Diel, R., Loddenkemper, R., Meywald-Walter, K., Niemann, S., & Nienhaus, A. (2008). Predictive Value of a Whole Blood IFN-γ Assay for the Development of Active Tuberculosis Disease after Recent Infection with Mycobacterium tuberculosis. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200711-1613oc
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