The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Effect of Bronchoscopic Lung Volume Reduction on Dynamic Hyperinflation and Exercise in Emphysema
Abstract
Endobronchial valve placement improves pulmonary function in some patients with chronic obstructive pulmonary disease, but its effects on exercise physiology have not been investigated. In 19 patients with a mean (SD) FEV(1) of 28.4 (11.9)% predicted, studied before and 4 weeks after unilateral valve insertion, functional residual capacity decreased from 7.1 (1.5) to 6.6 (1.7) L (p = 0.03) and diffusing capacity rose from 3.3 (1.1) to 3.7 (1.2) mmol . minute(-1) . kPa(-1) (p = 0.03). Cycle endurance time at 80% of peak workload increased from 227 (129) to 315 (195) seconds (p = 0.03). This was associated with a reduction in end-expiratory lung volume at peak exercise from 7.6 (1.6) to 7.2 (1.7) L (p = 0.03). Using stepwise logistic regression analysis, a model containing changes in transfer factor and resting inspiratory capacity explained 81% of the variation in change in exercise time (p < 0.0001). The same variables were retained if the five patients with radiologic atelectasis were excluded from analysis. In a subgroup of patients in whom invasive measurements were performed, improvement in exercise capacity was associated with a reduction in lung compliance (r(2) = 0.43; p = 0.03) and isotime esophageal pressure-time product (r(2) = 0.47; p = 0.03). Endobronchial valve placement can improve lung volumes and gas transfer in patients with chronic obstructive pulmonary disease and prolong exercise time by reducing dynamic hyperinflation.
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Cites
Vestbo, J., Hurd, S. S., Agustí, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., Barnes, P. J., Fabbri, L. M., Martinez, F. J., Nishimura, M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0596pp · Cited by 15,983
A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema
(2003) · New England Journal of Medicine · doi:10.1056/nejmoa030287 · Cited by 2,071
Dynamic Hyperinflation and Exercise Intolerance in Chronic Obstructive Pulmonary Disease
O'DONNELL, D. E., REVILL, S. M., & WEBB, K. A. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.5.2012122 · Cited by 1,076
O'DONNELL, D. E., LAM, M., & WEBB, K. A. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.5.9804004 · Cited by 532 · cited 3×
“However, on the basis of other studies that have looked at the effect of bronchodilators or LVRS in COPD ( 11 , 12, 24) the scale of improvement observed is unlikely to have occurred as a consequence of natural variation or a placebo effect.”
BackgroundResultInfluentialO'DONNELL, D. E., LAM, M., & WEBB, K. A. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.2.9901038 · Cited by 485
Contractile Properties of the Human Diaphragm during Chronic Hyperinflation
Similowski, T., Yan, S., Gauthier, A. P., Macklem, P. T., & Bellemare, F. (1991) · New England Journal of Medicine · doi:10.1056/nejm199109263251304 · Cited by 473
Belman, M. J., Botnick, W. C., & Shin, J. W. (1996) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.153.3.8630581 · Cited by 402
Diaphragm Activation during Exercise in Chronic Obstructive Pulmonary Disease
SINDERBY, C., SPAHIJA, J., BECK, J., KAMINSKI, D., YAN, S., COMTOIS, N., & SLIWINSKI, P. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.7.2007033 · Cited by 201
Effect of Lung Volume Reduction Surgery on Neuromechanical Coupling of the Diaphragm
LAGHI, F., JUBRAN, A., TOPELI, A., FAHEY, P. J., GARRITY, E. R., ARCIDI, J. M., de PINTO, D. J., EDWARDS, L. C., & TOBIN, M. J. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.2.9705082 · Cited by 108
Cited by
A Randomized Study of Endobronchial Valves for Advanced Emphysema
Sciurba, F. C., Ernst, A., Herth, F. J. F., Strange, C., Criner, G. J., Marquette, C. H., Kovitz, K. L., Chiacchierini, R. P., Goldin, J., & McLennan, G. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0900928 · Cited by 832
The major limitation to exercise performance in COPD is dynamic hyperinflation
O'Donnell, D. E., & Webb, K. A. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90336.2008b · Cited by 221
Physiologic Basis for Improved Pulmonary Function after Lung Volume Reduction
Fessler, H. E., Scharf, S. M., Ingenito, E. P., McKenna, R. J., & Sharafkhaneh, A. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200708-117et · Cited by 84
Zoumot, Z., Davey, C., Jordan, S., McNulty, W. H., Carr, D. H., Hind, M. D., Hansell, D. M., Rubens, M. B., Banya, W., Polkey, M. I., et al. (2015) · Efficacy and Mechanism Evaluation · doi:10.3310/eme02050 · Cited by 10
Self-citation
Metadata
- Authors
- Hopkinson, N. S., Toma, T. P., Hansell, D. M., Goldstraw, P., Moxham, J., Geddes, D. M., & Polkey, M. I.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-03-01
- Volume
- 171
- Issue
- 5
- Pages
- 453-460
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2065218757
- Cited by
- 243
- References
- 9
- FWCI
- 13.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hopkinson, N. S., Toma, T. P., Hansell, D. M., Goldstraw, P., Moxham, J., Geddes, D. M., & Polkey, M. I. (2005). Effect of Bronchoscopic Lung Volume Reduction on Dynamic Hyperinflation and Exercise in Emphysema. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200407-961oc
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
