A randomised controlled study of Bronchoscopic Lung Volume Reduction with endobronchial valves for patients with Heterogeneous emphysema and Intact interlobar Fissures: the BeLieVeR-HIFi study
Open accessAbstract
Background Despite optimal therapy many patients with emphysema remain significantly breathless and limited. Bronchoscopic lung volume reduction (BLVR), using valves placed to allow air to leave but not enter the worst-affected areas of the lung, has been proposed as a way to improve lung function in these patients, but response is variable because interlobar collateral ventilation prevents the devices from working. Based on retrospective analysis of clinical trials, patients with heterogeneous emphysema and intact interlobar fissures are most likely to benefit. Objectives To establish whether or not it is possible to identify patients prospectively who will reliably benefit from endobronchial valve placement. Design Prospective, randomised, parallel-group, double-blind, sham-controlled trial. Setting The study was performed at a single specialist centre. Participants Adult patients with heterogeneous emphysema and a target lobe with intact interlobar fissures were eligible if they had significant gas trapping (total lung capacity > 100% predicted, residual volume > 150% predicted), breathlessness [Medical Research Council (MRC) dyspnoea score of ≥ 3] and exercise limitation (6-minute walk distance of < 450 m). Participants were on optimised pharmacotherapy and were non-smokers. Interventions Study participants were randomised to either unilateral lobar endobronchial valve placement aiming to achieve lobar atelectasis or bronchoscopy and ‘sham’ valve placement. Main outcome measures The primary end point was improvement in forced expiratory volume in 1 second (FEV1) in the treatment arm compared with the control arm measured 90 days post procedure. Secondary end points were change in lung volumes, gas transfer, exercise capacity (both walking and endurance cycle ergometry) and health-related quality of life. Results In total, 50 patients were recruited, 25 to each arm; 62% were male and mean (standard deviation) FEV1% predicted was 31.7% (10.2%). The primary end point of the study was met as FEV1increased by 24.8% [95% confidence interval (CI) 8.0% to 41.5%] in the treatment arm and by 3.9% (95% CI 0.7% to 7.1%) in the control arm [between-group difference 20.9% (95% CI 4.3% to 37.5%);p = 0.033]. There were both statistically and clinically significant improvements in lung volumes and carbon monoxide gas transfer as well as endurance time and dynamic hyperinflation during cycle ergometry. Two deaths occurred in the treatment arm and one control patient was unable to attend for follow-up assessment because of a prolonged pneumothorax. Two pneumothoraces occurred in the treatment arm. Conclusions With appropriate selection of patients through a multidisciplinary team it is possible to produce a significant improvement in lung function through lobar occlusion with endobronchial valves in heterogeneous emphysema. Prospective trials are needed to compare the effect of BLVR with surgical approaches in terms of magnitude and duration of benefit. Trial registration Current Controlled Trials ISRCTN04761234. Funding This project was funded by the Efficacy and Mechanism Evaluation (EME) programme, a MRC and NIHR partnership.
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Breathlessness severity is not reliably predicted by the severity of airflow limitation/lung pathology in COPD.
“Its intensity is not reliably predicted by the severity of lung pathology”
From The Breathing, Thinking, Functioning clinical model: a proposal to facilitate evidence-based breathlessness management in chronic respiratory disease (2017) · cites this paper as [9]
The Results section reports that improved FEV1 was associated with reduced breathlessness during exercise, but does not assess whether the severity of lung pathology reliably predicts breathlessness intensity. Searches for that relationship, including dyspnoea severity and airflow obstruction, found no passage addressing the claim. (LLM, conf=0.72)
Experimental — accuracy not yet measured
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Cites
ATS Statement: Guidelines for the Six-Minute Walk Test
(2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.166.1.at1102 · Cited by 11,195 · see citing works
Celli, B. R., MacNee, W., Agustí, A. G. N., Anzueto, A. R., Berg, B., Buist, A. S., Calverley, P. M., Chavannes, N. H., Dillard, T. A., Fahy, B. F., et al. (2004) · European Respiratory Journal · doi:10.1183/09031936.04.00014304 · Cited by 4,414 · see citing works
(1993) · PubMed · Cited by 3,827 · see citing works
Development and first validation of the COPD Assessment Test
Jones, P., Harding, G., Berry, P., Wiklund, I. E., Chen, W.-H., & Leidy, N. K. (2009) · European Respiratory Journal · doi:10.1183/09031936.00102509 · Cited by 3,225 · see citing works
A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema
(2003) · New England Journal of Medicine · doi:10.1056/nejmoa030287 · Cited by 2,071 · see citing works
A Randomized Study of Endobronchial Valves for Advanced Emphysema
Sciurba, F. C., Ernst, A., Herth, F. J. F., Strange, C., Criner, G. J., Marquette, C., Kovitz, K. L., Chiacchierini, R. P., Goldin, J. G., & McLennan, G. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0900928 · Cited by 834 · see citing works
Minimum clinically important difference for the COPD Assessment Test: a prospective analysis
Kon, S. S. C., Canavan, J. L., Jones, S. E., Nolan, C. M., Clark, A. L., Dickson, M. J., Haselden, B. M., Polkey, M. I., & Man, W. D. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(14)70001-3 · Cited by 673 · see citing works
Self-citationThe minimal important difference of exercise tests in severe COPD
Puhan, M. A., Chandra, D., Mosenifar, Z., Ries, A. L., Make, B. J., Hansel, N. N., Wise, R. A., & Sciurba, F. C. (2010) · European Respiratory Journal · doi:10.1183/09031936.00063810 · Cited by 406 · see citing works
Effect of Lung-Volume–Reduction Surgery in Patients with Severe Emphysema
Geddes, D. M., Davies, M. G., Koyama, H., Hansell, D. M., Pastorino, U., Pepper, J., Agent, P., Cullinan, P., MacNeill, S., & Goldstraw, P. G. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007273430402 · Cited by 399 · see citing works
Self-citationDavey, C., Zoumot, Z., Jordan, S. J., McNulty, W. H., Carr, D., Hind, M. D., Hansell, D. M., Rubens, M. B., BANYA, W. A. S., Polkey, M. I., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60001-0 · Cited by 363 · see citing works
Self-citationMeguro, M., Barley, E. A., Spencer, S., & Jones, P. W. (2007) · Chest · doi:10.1378/chest.06-0702 · Cited by 350 · see citing works
Naunheim, K. S., Wood, D. E., Mohsenifar, Z., Sternberg, A. L., Criner, G. J., DeCamp, M. M., Deschamps, C. C., Martínez, F. J., Sciurba, F. C., Tonascia, J. A., et al. (2006) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2006.05.069 · Cited by 346 · see citing works
Dodd, J. W., Hogg, L., Nolan, J., Jefford, H., Grant, A., Lord, V. M., Falzon, C., Garrod, R., Lee, C., Polkey, M. I., et al. (2011) · Thorax · doi:10.1136/thx.2010.156372 · Cited by 303 · see citing works
Self-citationBronchoscopic volume reduction with valve implants in patients with severe emphysema.
Toma, T., Hopkinson, N. S., Hillier, J., Hansell, D. M., Morgan, C., Goldstraw, P. G., Polkey, M. I., & Geddes, D. M. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12762-6 · Cited by 299 · see citing works
Self-citationRadiological and clinical outcomes of using Chartis™ to plan endobronchial valve treatment
Herth, F. J. F., Eberhardt, R., Gompelmann, D., Ficker, J. H., Wagner, M., Ek, L., Schmidt, B., & Slebos, D. (2012) · European Respiratory Journal · doi:10.1183/09031936.00015312 · Cited by 275 · see citing works
Effect of bronchoscopic lung volume reduction on dynamic hyperinflation and exercise in emphysema.
Hopkinson, N., Toma, T., Hansell, D., Goldstraw, P., Moxham, J., Geddes, D., & Polkey, M. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200407-961oc · Cited by 270 · see citing works
Self-citationShah, P. L., Slebos, D.-J., Cardoso, P., Cetti, E. J., Voelker, K. G., Levine, B. E., Russell, M., Goldin, J. G., Brown, M. S., Cooper, J., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)61050-7 · Cited by 230 · see citing works
Self-citationBronchoscopic Lung Volume Reduction for End-Stage Emphysema
Wan, I. Y. P., Toma, T., Geddes, D. M., Snell, G. I., Williams, T. J., Venuta, F., & Yim, A. P. C. (2006) · CHEST Journal · doi:10.1378/chest.129.3.518 · Cited by 230 · see citing works
Shah, P. L., Zoumot, Z., Singh, S., Bicknell, S. R., Ross, E. T., Quiring, J. N., Hopkinson, N. S., & Kemp, S. V. (2013) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70047-x · Cited by 229 · see citing works
Self-citationCriner, G. J., CORDOVA, F. C., Sternberg, A. L., & Martínez, F. J. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201103-0455ci · Cited by 206 · see citing works
Bronchoscopic Lung Volume Reduction Coil Treatment of Patients With Severe Heterogeneous Emphysema
Slebos, D., Klooster, K., Ernst, A., Herth, F. J. F., & Kerstjens, H. A. M. (2011) · CHEST Journal · doi:10.1378/chest.11-0730 · Cited by 189 · see citing works
Schünemann, H. J. (2003) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(03)00115-x · Cited by 175 · see citing works
A multicenter trial of an intrabronchial valve for treatment of severe emphysema
Wood, D. E., McKenna, R. J., Yusen, R. D., Sterman, D. H., Ost, D. E., Springmeyer, S. C., Gonzalez, H. X., Mulligan, M. S., Gildea, T. R., Houck, W. V., et al. (2006) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2006.06.051 · Cited by 172 · see citing works
The Potential for Bronchoscopic Lung Volume Reduction Using Bronchial Prostheses
Snell, G. I., Holsworth, L., Borrill, Z., Thomson, K. R., Kalff, V., Smith, J. A., & Williams, T. J. (2003) · CHEST Journal · doi:10.1378/chest.124.3.1073 · Cited by 168 · see citing works
Bronchoscopic lung volume reduction with a dedicated coil: a clinical pilot study
Herth, F. J. F., Eberhard, R., Gompelmann, D., Slebos, D., & Ernst, A. (2010) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753465810368553 · Cited by 148 · see citing works
Bronchial fenestration improves expiratory flow in emphysematous human lungs
Lausberg, H., Chino, K., Patterson, G. A., Meyers, B. F., Toeniskoetter, P. D., & Cooper, J. D. (2003) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(02)04553-8 · Cited by 145 · see citing works
Early results of endoscopic lung volume reduction for emphysema
Yim, A. P. C., Hwong, T. M. T., Lee, T. W., Li, W. W. L., Lam, S., Yeung, T. K., Hui, D. S. C., Ko, F. W. S., Sihoe, A. D. L., Thung, K. H., et al. (2004) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2003.10.005 · Cited by 140 · see citing works
Atelectasis and survival after bronchoscopic lung volume reduction for COPD
Hopkinson, N. S., Kemp, S. V., Toma, T. P., Hansell, D. M., Geddes, D. M., Shah, P. L., & Polkey, M. I. (2010) · European Respiratory Journal · doi:10.1183/09031936.00100110 · Cited by 139 · see citing works
Self-citationDeslée, G., Klooster, K., Hetzel, M., Stanzel, F., Kessler, R., Marquette, C., Witt, C. C., Blaas, S. H., Gesierich, W., Herth, F. J. F., et al. (2014) · Thorax · doi:10.1136/thoraxjnl-2014-205221 · Cited by 138 · see citing works
Multicentre European study for the treatment of advanced emphysema with bronchial valves
Ninane, V., Geltner, C., Bezzi, M., Foccoli, P., Gottlieb, J., Welte, T., Seijo, L. M., Zulueta, J. J., Munavvar, M., Rosell, A., et al. (2012) · European Respiratory Journal · doi:10.1183/09031936.00019711 · Cited by 125 · see citing works
Treatment of Advanced Emphysema with Emphysematous Lung Sealant (AeriSeal®)
Herth, F. J. F., Gompelmann, D., Stanzel, F., Bonnet, R. B., Behr, J., Schmidt, B., MAGNUSSEN, H., Ernst, A., & Eberhardt, R. (2011) · Respiration · doi:10.1159/000322649 · Cited by 123 · see citing works
Bronchoscopic Lung-Volume Reduction With One-Way Valves in Patients With Heterogenous Emphysema
Venuta, F., Giacomo, T. D., Rendina, E. A., Ciccone, A. M., Diso, D., Perrone, A., Parola, D., Anile, M., & Coloni, G. F. (2005) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2004.07.048 · Cited by 115 · see citing works
Casaburi, R. H. (2005) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.1081/copd-200050576 · Cited by 111 · see citing works
Lung function indices for predicting mortality in COPD
Boutou, A., Shrikrishna, D., Tanner, R., Smith, C., Kelly, J. L., Ward, S. P., Polkey, M. I., & Hopkinson, N. S. (2013) · European Respiratory Journal · doi:10.1183/09031936.00146012 · Cited by 105 · see citing works
Self-citationThe minimal important difference for residual volume in patients with severe emphysema
Hartman, J. E., ten Hacken, N. H. T., Klooster, K., Boezen, H. M., Greef, M. H. G. D., & Slebos, D. (2012) · European Respiratory Journal · doi:10.1183/09031936.00219111 · Cited by 102 · see citing works
Current status of bronchoscopic lung volume reduction with endobronchial valves
Shah, P. L., & Herth, F. J. F. (2013) · Thorax · doi:10.1136/thoraxjnl-2013-203743 · Cited by 100 · see citing works
Self-citationKelly, J. L., Bamsey, O., Smith, C., Lord, V. M., Shrikrishna, D., Jones, P., Polkey, M. I., & Hopkinson, N. S. (2012) · Respiration · doi:10.1159/000336549 · Cited by 99 · see citing works
Self-citationEmphysema: time to say farewell to therapeutic nihilism
Zoumot, Z., Jordan, S. J., & Hopkinson, N. S. (2014) · Thorax · doi:10.1136/thoraxjnl-2014-205667 · Cited by 77 · see citing works
Self-citationFessler, H. E., Scharf, S. M., & Permutt, S. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.1.2101149 · Cited by 71 · see citing works
Improved Exercise Performance Following Lung Volume Reduction Surgery for Emphysema
Ferguson, G. T., FERNANDEZ, E., Zamora, M., Pomerantz, M., BUCHHOLZ, J., & Make, B. J. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.4.9705008 · Cited by 70 · see citing works
Treatment of Heterogeneous Emphysema Using the Spiration IBV Valves
Springmeyer, S. C., Bolliger, C. T., Waddell, T. K., Gonzalez, X., & Wood, D. E. (2009) · Thoracic surgery clinics/Thorac. surg. clin. · doi:10.1016/j.thorsurg.2009.02.005 · Cited by 61 · see citing works
Transbronchoscopic Pulmonary Emphysema Treatment
de Oliveira, H. G., de Macedo-Neto, A. V., John, Â. B., Jungblut, S., Prolla, J. C., Menna‐Barreto, S. S., & Fortis, E. A. F. (2006) · CHEST Journal · doi:10.1378/chest.130.1.190 · Cited by 60 · see citing works
Aljuri, N., & Freitag, L. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91075.2008 · Cited by 60 · see citing works
Surgical approaches for lung volume reduction in emphysema
Clark, S. J., Zoumot, Z., Bamsey, O., Polkey, M. I., Dusmet, M. E., Lim, E. K. S., Jordan, S. J., & Hopkinson, N. S. (2014) · Clinical Medicine · doi:10.7861/clinmedicine.14-2-122 · Cited by 58 · see citing works
Self-citationDavey, C., Zoumot, Z., Jordan, S., Carr, D. H., Polkey, M. I., Shah, P. L., & Hopkinson, N. S. (2014) · Thorax · doi:10.1136/thoraxjnl-2014-205127 · Cited by 54 · see citing works
Self-citationZoumot, Z., Kemp, S. V., Singh, S., Bicknell, S. R., McNulty, W. H., Hopkinson, N. S., Ross, E. T., & Shah, P. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122656 · Cited by 53 · see citing works
Self-citationEffect of Blood Transfusion on the Carbon Monoxide Transfer Factor of the Lung in Man
Clark, E. H., Woods, R. L., & Hughes, J. M. B. (1978) · Clinical Science · doi:10.1042/cs0540627 · Cited by 48 · see citing works
Venn, G. E., Williams, P. R., & Goldstraw, P. G. (1988) · Thorax · doi:10.1136/thx.43.12.998 · Cited by 45 · see citing works
Lung Volume Reduction by Bronchoscopic Administration of Steam
Emery, M. J., Eveland, R. L., Eveland, K. B., Couëtil, L. L., Hildebrandt, J., & Swenson, E. R. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201001-0102oc · Cited by 38 · see citing works
McNulty, W. H., Jordan, S. J., Hopkinson, N. S., & on behalf of The British Thoracic Society (2014) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2014-000023 · Cited by 37 · see citing works
Self-citationBronchoscopic lung volume reduction: indications, effects and prospects
Hopkinson, N. S. (2007) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e328012e053 · Cited by 30 · see citing works
Self-citationUnilateral Extrapulmonary Airway Bypass in Advanced Emphysema
Moore, A., Cetti, E. J., Haj‐Yahia, S., Carby, M. R., Björling, G., Karlsson, S., Shah, P. L., Goldstraw, P. G., Moxham, J., Jordan, S. J., et al. (2010) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2009.10.067 · Cited by 26 · see citing works
Self-citationThe lung volume reduction coil for the treatment of emphysema: a new therapy in development
Klooster, K., ten Hacken, N. H. T., & Slebos, D. (2014) · Expert Review of Medical Devices · doi:10.1586/17434440.2014.929490 · Cited by 25 · see citing works
Intrabullous blood injection for lung volume reduction
Kanoh, S., Kobayashi, H., & Motoyoshi, K. (2008) · Thorax · doi:10.1136/thx.2007.087957 · Cited by 23 · see citing works
Effect and Duration of Lung Volume Reduction Surgery: Mid-Term Results of the Brompton Trial
Lim, E. K. S., Ali, A., Cartwright, N., Sousa, I., Chetwynd, A. G., Polkey, M. I., Geddes, D. M., Pepper, J., Diggle, P. J., & Goldstraw, P. G. (2006) · The Thoracic and Cardiovascular Surgeon · doi:10.1055/s-2005-872953 · Cited by 16 · see citing works
Self-citationPulmonary stem cells and the induction of tissue regeneration in the treatment of emphysema.
Lenssen, J., & Stolk, J. N. (2007) · PubMed Central · Cited by 15 · see citing works
Eberhardt, R., Schmidt, B., Ernst, A., Ficker, J. H., Snell, G. I., & Herth, F. J. F. (2009) · CHEST Journal · doi:10.1378/chest.136.4_meetingabstracts.78s · Cited by 4 · see citing works
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- Davey C, Zoumot Z, Jordan S, McNulty WH, Carr DH, Hind MD, et al. Bronchoscopic lung volume reduction with endobronchial valves for patients with heterogeneous emphysema and intact interlobar fissures (The BeLieVeR-HIFi study) -a randomised controlled trial. Lancet 2015; in press.
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“In a recent controlled trial, bronchoscopic lung volume reduction significantly improved FEV1 by 25%, without relief of breathlessness.(9) The inconsistent relationship between pathology and breathlessness perception explains why optimising disease management alone does not guarantee good symptom control.”
BackgroundPatel, M., Chowdhury, J. M., Zhao, H., Lu, X., Roth, S. C., Giovacchini, C. X., Wahidi, M. M., & Criner, G. J. (2022) · Journal of Bronchology & Interventional Pulmonology · doi:10.1097/lbr.0000000000000872 · Cited by 37 · see citing works
Service delivery of complex interventions for refractory breathlessness
Booth, S., Ryan, R., & Spathis, A. (2016) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000227 · Cited by 15 · see citing works
Egenod, T., Tricard, J., Fumat, R., Simonneau, Y., Favard, F., Guillot, M.-S., Collot, S., Dupuis, M., Melloni, B., Vergnenégre, A., et al. (2021) · International Journal of COPD · doi:10.2147/copd.s307829 · Cited by 13 · see citing works
Non-pharmacological interventions for breathlessness in people with cancer
Booth, S., Chin, C. A., Spathis, A., Maddocks, M. M., Yorke, J., Burkin, J., Moffat, C., Farquhar, M. C., & Bausewein, C. (2018) · Expert Review of Quality of Life in Cancer Care · doi:10.1080/23809000.2018.1524708 · Cited by 9 · see citing works
Surgical and Bronchoscopic Lung Volume Reduction in Chronic Obstructive Pulmonary Disease
Meena, M., Dixit, R., Singh, M., Samaria, J. K., & Kumar, S. (2014) · Pulmonary Medicine · doi:10.1155/2014/757016 · Cited by 7 · see citing works
The construct of breathlessness
Booth, S., & Lansing, R. (2016) · European Respiratory Society eBooks · doi:10.1183/2312508x.10011515 · Cited by 2 · see citing works
Endobronchial Lung Volume Reduction Therapies
Holden, V. K., Alsunaid, S. R., Charya, A. V., Alghanim, F., Pickering, E. M., & Sachdeva, A. (2021) · Current Pulmonology Reports · doi:10.1007/s13665-020-00266-8 · Cited by 1 · see citing works
Endoscopic Management of Emphysema
Gasparini, S., & Bonifazi, M. (2020) · Wiley eBooks · doi:10.1002/9781119389231.ch29
Symptom Management for Older Adults with Pulmonary Disease
Spathis, A., & Donesky, D. (2025) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2025.07.007
- Authors
- Zoumot, Z., Davey, C., Jordan, S., McNulty, W. H., Carr, D. H., Hind, M. D., Hansell, D. M., Rubens, M. B., Banya, W., Polkey, M. I., Shah, P. L., & Hopkinson, N. S.
- Affiliations
- Royal Brompton & Harefield NHS Foundation Trust (GB)
- ORCID
- Venue
- Efficacy and Mechanism Evaluation
- Published
- 2015-09
- Volume
- 2
- Issue
- 5
- Pages
- 1-34
- ISSN
- 2050-4365 (ISSN-L)
- 2050-4373
- OpenAlex
- W2413332282
- Cited by
- 10
- References
- 57
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2014: 1
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Efficacy and Mechanism Evaluation (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Efficacy and Mechanism Evaluation programme (10/90/10)
- Medical Research Council
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Keywords
- heterogeneous emphysema, endobronchial valves, bronchoscopic lung volume reduction, interlobar fissure, lobar atelectasis, air trapping, FEV1, dyspnea, exercise capacity, lung function, patient selection, health-related quality of life, lung volume, gas transfer, cycle ergometry, 6-minute walk distance, chronic obstructive pulmonary disease
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