The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
Severe Asthma in Adults
Abstract
Severe asthma remains poorly understood and frustrating to care for, partly because it is a heterogeneous disease. Patients with severe asthma disproportionately consume health care resources related to asthma. Severe asthma may develop over time, or shortly after onset of the disease. The genetic and environmental elements that may be most important in the development of severe disease are poorly understood, but likely include both allergic and nonallergic elements. Physiologically, these patients often have air trapping, airway collapsibility, and a high degree of methacholine hyperresponsiveness. Specific phenotypes of severe asthma are only beginning to be defined. However, describing severe asthma by age at onset (early- vs. late-onset) appears to describe two phenotypes that differ at immunologic, physiologic, epidemiologic, and pathologic levels. In particular, early-onset severe asthma is a more allergic-associated disease than late-onset severe asthma. In addition, patients with severe asthma can be defined on the basis of presence and type of inflammation. Severe asthma with persistent eosinophilia (of either early or late onset) is more symptomatic and has more near-fatal events. However, at least 50% of patients with severe asthma have very little identifiable inflammation. Thus, "steroid resistance" may occur at numerous levels, not all of which are caused by a lack of effect of steroids on inflammation. Treatment remains problematic, with corticosteroids remaining the most effective therapy. However, 5-lipoxygenase inhibitors, anti-IgE, and immunomodulatory drugs are also likely to have a place in treatment. Improving therapy in this disease will require a better understanding of the phenotypes involved.
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Cites
Can Guideline-defined Asthma Control Be Achieved?: The Gaining Optimal Asthma ControL Study
Bateman, E. D., Boushey, H. A., Bousquet, J., Busse, W. W., Clark, T. J. H., Pauwels, R. A., & Pedersen, S. E. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200401-033oc · Cited by 1,594
A longitudinal, population-based, cohort study of childhood asthma followed to adulthood
Sears, M. R., Greene, J. M., Willan, A. R., Wiecek, E. M., Taylor, D. R., Flannery, E. M., Cowan, J. O., Herbison, G. P., Silva, P. A., & Poulton, R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022363 · Cited by 1,460
Rosenstreich, D. L., Eggleston, P., Kattan, M., Baker, D., Slavin, R. G., Gergen, P., Mitchell, H., McNiff-Mortimer, K., Lynn, H., Ownby, D., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199705083361904 · Cited by 1,380
A 15-year follow-up study of ventilatory function in adults with asthma
Lange, P., Parner, J., Vestbo, J., Schnohr, P., & Jensen, G. (1998) · New England Journal of Medicine · doi:10.1056/nejm199810223391703 · Cited by 1,250
WENZEL, S. E., SCHWARTZ, L. B., LANGMACK, E. L., HALLIDAY, J. L., TRUDEAU, J. B., GIBBS, R. L., & CHU, H. W. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.3.9812110 · Cited by 1,235
Self-citationDrysdale, C. M., McGraw, D. W., Stack, C. B., Stephens, J. C., Judson, R. S., Nandabalan, K., Arnold, K., Ruano, G., & Liggett, S. B. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.19.10483 · Cited by 964
(2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.6.ats9-00 · Cited by 909
Neutrophilic Inflammation in Severe Persistent Asthma
JATAKANON, A., UASUF, C., MAZIAK, W., LIM, S., CHUNG, K. F., & BARNES, P. J. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.5.9806170 · Cited by 851
Green, R. H. (2002) · Thorax · doi:10.1136/thorax.57.10.875 · Cited by 848
Airway Structural Alterations Selectively Associated with Severe Asthma
Benayoun, L., Druilhe, A., Dombret, M.-C., Aubier, M., & Pretolani, M. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200209-1030oc · Cited by 800
Cited by
Global strategy for asthma management and prevention: GINA executive summary
Bateman, E. D., Hurd, S. S., Barnes, P. J., Bousquet, J., Drazen, J. M., FitzGerald, M., Gibson, P., Ohta, K., O'Byrne, P., Pedersen, S. E., et al. (2008) · European Respiratory Journal · doi:10.1183/09031936.00138707 · Cited by 3,203
Self-citationBullens, D. M., Truyen, E., Coteur, L., Dilissen, E., Hellings, P. W., Dupont, L. J., & Ceuppens, J. L. (2006) · Respiratory Research · doi:10.1186/1465-9921-7-135 · Cited by 587
T H 2 and T H 17 inflammatory pathways are reciprocally regulated in asthma
Choy, D. F., Hart, K. M., Borthwick, L. A., Shikotra, A., Nagarkar, D. R., Siddiqui, S., Jia, G., Ohri, C. M., Doran, E., Vannella, K. M., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aab3142 · Cited by 450
Uncontrolled asthma: A review of the prevalence, disease burden and options for treatment
Peters, S. P., Ferguson, G., Deniz, Y., & Reisner, C. (2006) · Respiratory Medicine · doi:10.1016/j.rmed.2006.03.031 · Cited by 320
Macrophage heterogeneity in respiratory diseases
Boorsma, C. E., Draijer, C., & Melgert, B. N. (2013) · Mediators of Inflammation · doi:10.1155/2013/769214 · Cited by 126
Metadata
- Authors
- Wenzel, S.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-07-15
- Volume
- 172
- Issue
- 2
- Pages
- 149-160
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2093025649
- Cited by
- 309
- References
- 105
- FWCI
- 14.41
- Type
- journal article
- Language
- en
- Open access
- closed
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