The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx?
Open accessAbstract
BACKGROUND: The role of Th2 cells (producing interleukin (IL-)4, IL-5 and IL-13) in allergic asthma is well-defined. A distinct proinflammatory T cell lineage has recently been identified, called Th17 cells, producing IL-17A, a cytokine that induces CXCL8 (IL-8) and recruits neutrophils. Neutrophilic infiltration in the airways is prominent in severe asthma exacerbations and may contribute to airway gland hypersecretion, bronchial hyper-reactivity and airway wall remodelling in asthma. AIM: to study the production of IL-17 in asthmatic airways at the mRNA level, and to correlate this with IL-8 mRNA, neutrophilic inflammation and asthma severity. METHODS: We obtained airway cells by sputum induction from healthy individuals (n = 15) and from asthmatic patients (n = 39). Neutrophils were counted on cytospins and IL-17A and IL-8 mRNA expression was quantified by real-time RT-PCR (n = 11 controls and 33 asthmatics). RESULTS: Sputum IL-17A and IL-8 mRNA levels are significantly elevated in asthma patients compared to healthy controls. IL-17 mRNA levels are significantly correlated with CD3gamma mRNA levels in asthmatic patients and mRNA levels of IL-17A and IL-8 correlated with each other and with sputum neutrophil counts. High sputum IL-8 and IL-17A mRNA levels were also found in moderate-to-severe (persistent) asthmatics on inhaled steroid treatment. CONCLUSION: The data suggest that Th17 cell infiltration in asthmatic airways links T cell activity with neutrophilic inflammation in asthma.
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Cites
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Cited by
Targeting IL-17 and TH17 cells in chronic inflammation
Miossec, P., & Kolls, J. K. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3794 · Cited by 1,414
The cytokine network in asthma and chronic obstructive pulmonary disease
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The roles of IL‐17A in inflammatory immune responses and host defense against pathogens
Iwakura, Y., Nakae, S., Saijo, S., & Ishigame, H. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00699.x · Cited by 513
The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin
Weaver, C. T., Elson, C. O., Fouser, L. A., & Kolls, J. K. (2013) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130318 · Cited by 462
Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza
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Metadata
- Authors
- Bullens, D. M., Truyen, E., Coteur, L., Dilissen, E., Hellings, P. W., Dupont, L. J., & Ceuppens, J. L.
- Venue
- Respiratory Research
- Published
- 2006-11-03
- Volume
- 7
- Issue
- 1
- Pages
- 135-135
- ISSN
- 1465-9921 (ISSN-L)
- 1465-993X
- OpenAlex
- W2163529289
- Cited by
- 587
- References
- 40
- FWCI
- 13.72
- Type
- journal article
- Language
- en
- Open access
- gold
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- Bullens, D. M., Truyen, E., Coteur, L., Dilissen, E., Hellings, P. W., Dupont, L. J., & Ceuppens, J. L. (2006). IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx? Respiratory Research. https://doi.org/10.1186/1465-9921-7-135
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