CoChat
Sign Up
Cited by 509Respiratory Support and MechanismsNeonatal Respiratory Health ResearchNosocomial Infections in ICU

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Tidal Volume Reduction in Patients with Acute Lung Injury When Plateau Pressures Are Not High

Open access
Hager, David N., Krishnan, Jerry A., Hayden, Douglas L., Brower, Roy G.·2005·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/rccm.200501-048cpPMC PMC2718413
Open this paper in CoChat — free account

Abstract

Use of a volume- and pressure-limited mechanical ventilation strategy improves clinical outcomes of patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS). However, the extent to which tidal volumes and inspiratory airway pressures should be reduced to optimize clinical outcomes is a controversial topic. This article addresses the question, “Is there a safe upper limit to inspiratory plateau pressure in patients with ALI/ARDS?” We reviewed data from animal models with and without preexisting lung injury, studies of normal human respiratory system mechanics, and the results of five clinical trials of lung-protective mechanical ventilation strategies. We also present an original analysis of data from the largest of the five clinical trials. The available data from each of these assessments do not support the commonly held view that inspiratory plateau pressures of 30 to 35 cm H2O are safe. We could not identify a safe upper limit for plateau pressures in patients with ALI/ARDS.

Overview

Integrity signals

Registry

Crossref · 10.1164/rccm.200501-048cp

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 46

  1. 1993, Chest, 1833
  2. 2005, Crit Care Med, 925
  3. 1998, N Engl J Med, 347
  4. 2000, N Engl J Med, 1301
  5. 1990, Intensive Care Med, 372
  6. 2002, Am J Respir Crit Care Med, 242
  7. 2001, Crit Care Med, 392
  8. 2003, Am J Respir Crit Care Med, 933
  9. 2005, Crit Care Med, 1141
  10. 2003, Eur Respir J Suppl, 15s
  11. 2002, Am J Respir Crit Care Med, 1510
  12. 2000, N Engl J Med, 1360
  13. 2003, Am J Respir Crit Care Med, 1297
  14. 2002, Am J Respir Crit Care Med, 1510
  15. 2002, Am J Respir Crit Care Med, 933
  16. 2002, Intensive Care Med, 230
  17. 2002, Am J Respir Crit Care Med, 1515
  18. 2004, Chest, 592
  19. 1998, Am J Respir Crit Care Med, 294
  20. 1993, Crit Care Med, 131
  21. 1946, Am J Physiol, 161
  22. 1998, N Engl J Med, 355
  23. 1999, Crit Care Med, 1492
  24. 1998, Am J Respir Crit Care Med, 1831
  25. 2003, Am J Respir Crit Care Med, A616
  26. 1993, J Pediatr Surg, 488
  27. 1988, Am Rev Respir Dis, 1159
  28. 1974, Am Rev Respir Dis, 556
  29. 1993, J Appl Physiol, 3068
  30. 1988, Intensive Care Med, 8
  31. 1990, J Appl Physiol, 956
  32. 1984, J Appl Physiol, 1809
  33. 1990, Am Rev Respir Dis, 321
  34. 1990, J Appl Physiol, 577
  35. 2004, JAMA, 1603
  36. 1993, New Horiz, 489
  37. 2005, Ann Intern Med, 283
  38. 2002, Crit Care Clin, 1
  39. 2003, Am J Respir Crit Care Med, 612
  40. 1990, Crit Care Med, 103
  41. 1991, Chest, 1619
  42. 2000, Am J Respir Crit Care Med, 209
  43. 1994, Am J Respir Crit Care Med, 1722
  44. 1971, J Appl Physiol, 909
  45. 2005, Crit Care Med, 1143
  46. 1979, J Am Stat Assoc, 829

Cited by

Sorted by citations

See all 509

Related

See all

Metadata

Authors
Hager, D. N., Krishnan, J. A., Hayden, D. L., & Brower, R. G.
Affiliations
Johns Hopkins University (US)
ORCID
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
2005-11
Volume
172
Issue
10
Pages
1241-1245
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
DOI
10.1164/rccm.200501-048cp
PMC
PMC2718413
OpenAlex
W2168829312
Cited by
509
References
45
Citations by year
2026: 5 · 2025: 5 · 2024: 12 · 2023: 7 · 2022: 17 · 2021: 28 · 2020: 29 · 2019: 25 · 2018: 16 · 2017: 34 · 2016: 28 · 2015: 34 · 2014: 34 · 2013: 29 · 2012: 30
FWCI
4.59
Type
journal article
Language
en
Open access
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • American Journal of Respiratory and Critical Care Medicine (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (n01hr046063-006, n01hr046064-009)
  • National Heart, Lung, and Blood Institute (K23HL067850, N01-HR-46063, K23-HL67850, P50HL073944, N01-HR46064, F32HL078132)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
Keywords
acute lung injury, acute respiratory distress syndrome, tidal volume reduction, plateau pressure, lung-protective ventilation, pressure-limited ventilation, ventilator-induced lung injury, respiratory mechanics, animal models of lung injury
MeSH terms
Animals, Humans, Respiration, Artificial, Respiratory Distress Syndrome, Tidal Volume, Logistic Models, Models, Animal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review