The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Titrating Steroids on Exhaled Nitric Oxide in Children with Asthma: A Randomized Controlled Trial
Open accessAbstract
RATIONALE: Corticosteroids are the antiinflammatory treatment of choice in asthma. Treatment guidelines are mainly symptom-driven but symptoms are not closely related to airway inflammation. The fraction of nitric oxide in exhaled air (FENO) is a marker of airway inflammation in asthma. OBJECTIVE: We evaluated whether titrating steroids on FENO improved asthma management in children. METHODS: Eighty-five children with atopic asthma, using inhaled steroids, were allocated to a FENO group (n=39) in which treatment decisions were made on both FENO and symptoms, or to a symptom group (n=46) treated on symptoms only. Children were seen every 3 months over a 1-year period. MEASUREMENTS: Symptoms were scored during 2 weeks before visits and 4 weeks before the final visit. FeNO was measured at all visits, and airway hyperresponsiveness and FEV1 were measured at the start and end of the study. Primary endpoint was cumulative steroid dose. RESULTS: Changes in steroid dose from baseline did not differ between groups. In the FENO group, hyperresponsiveness improved more than in the symptom group (2.5 vs. 1.1 doubling dose, p=0.04). FEV1 in the FENO group improved, and the change in FEV1 was not significantly different between groups. The FENO group had 8 severe exacerbations versus 18 in the symptom group. The change in symptom scores did not differ between groups. FENO increased in the symptom group; the change in FENO from baseline differed between groups (p=0.02). CONCLUSION: In children with asthma, 1 year of steroid titration on FENO did not result in higher steroid doses and did improve airway hyperresponsiveness and inflammation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial
Green, R. H., Brightling, C. E., McKenna, S., Hargadon, B., Parker, D., Bradding, P., Wardlaw, A. J., & Pavord, I. D. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11679-5 · Cited by 1,755
A longitudinal, population-based, cohort study of childhood asthma followed to adulthood
Sears, M. R., Greene, J. M., Willan, A. R., Wiecek, E. M., Taylor, D. R., Flannery, E. M., Cowan, J. O., Herbison, G. P., Silva, P. A., & Poulton, R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022363 · Cited by 1,460
Increased amount of nitric oxide in exhaled air of asthmatics
Alving, K., Weitzberg, E., & Lundberg, J. (1993) · European Respiratory Journal · doi:10.1183/09031936.93.06091368 · Cited by 1,232
Use of Exhaled Nitric Oxide Measurements to Guide Treatment in Chronic Asthma
Smith, A. D., Cowan, J. O., Brassett, K. P., Herbison, G. P., & Taylor, D. R. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043596 · Cited by 974
SONT, J. K., WILLEMS, L. N. A., BEL, E. H., van KRIEKEN, J. H. J. M., VANDENBROUCKE, J. P., STERK, P. J., & the AMPUL Study Group (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.159.4.9806052 · Cited by 885
Exhaled Markers of Pulmonary Disease
KHARITONOV, S. A., & BARNES, P. J. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.7.2009041 · Cited by 844
Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients.
Kharitonov, S. A., Yates, D. H., & Barnes, P. J. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.1.8542158 · Cited by 580
PAYNE, D. N. R., ADCOCK, I. M., WILSON, N. M., OATES, T., SCALLAN, M., & BUSH, A. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.8.2101145 · Cited by 463
Airway Inflammation Is Present during Clinical Remission of Atopic Asthma
VAN DEN TOORN, L. M., OVERBEEK, S. E., DE JONGSTE, J. C., LEMAN, K., HOOGSTEDEN, H. C., & PRINS, J.-B. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.11.2006165 · Cited by 445
Self-citationInhaled Corticosteroids for Asthma Therapy
Cochrane, M. G., Bala, M. V., Downs, K. E., Mauskopf, J., & Ben-Joseph, R. H. (2000) · Chest · doi:10.1378/chest.117.2.542 · Cited by 428
Cited by
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
Chung, K. F., Wenzel, S. E., Brozek, J. L., Bush, A., Castro, M., Sterk, P. J., Adcock, I. M., Bateman, E. D., Bel, E. H., Bleecker, E. R., et al. (2014) · European Respiratory Journal · doi:10.1183/09031936.00202013 · Cited by 3,926
Reddel, H. K., Taylor, D. R., Bateman, E. D., Boulet, L.-P., Boushey, H. A., Busse, W. W., Casale, T. B., Chanez, P., Enright, P. L., Gibson, P. G., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200801-060st · Cited by 1,918
Self-citationCloutier, M. M., Baptist, A. P., Blake, K. V., Brooks, E. G., Bryant-Stephens, T., DiMango, E., Dixon, A. E., Elward, K. S., Hartert, T., Krishnan, J. A., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.10.003 · Cited by 854
Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report
Bacharier, L. B., Boner, A., Carlsen, K. ‐., Eigenmann, P. A., Frischer, T., Götz, M., Helms, P. J., Hunt, J., Liu, A., Papadopoulos, N., et al. (2008) · Allergy · doi:10.1111/j.1398-9995.2007.01586.x · Cited by 640
Exhaled nitric oxide measurements: clinical application and interpretation
Taylor, D. R., Pijnenburg, M. W., Smith, A. D., & Jongste, J. C. D. (2006) · Thorax · doi:10.1136/thx.2005.056093 · Cited by 507
Self-citation
Metadata
- Authors
- Pijnenburg, M. W., Bakker, E. M., Hop, W. C., & De Jongste, J. C.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-10-01
- Volume
- 172
- Issue
- 7
- Pages
- 831-836
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2152345375
- Cited by
- 346
- References
- 38
- FWCI
- 23.54
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Titrating Steroids on Exhaled Nitric Oxide in Children with Asthma: A Randomized Controlled Trial. https://app.cochat.ai/papers/10.1164/rccm.200503-458oc
- The paper
- Pijnenburg, M. W., Bakker, E. M., Hop, W. C., & De Jongste, J. C. (2005). Titrating Steroids on Exhaled Nitric Oxide in Children with Asthma: A Randomized Controlled Trial. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200503-458oc
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
