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Cited by 650Asthma and respiratory diseasesOccupational exposure and asthmaChronic Obstructive Pulmonary Disease (COPD) Research

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Outcome of Asthma and Wheezing in the First 6 Years of Life

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Morgan, Wayne J., Stern, Debra A., Sherrill, Duane L., Guerra, Stefano, Holberg, Catharine J., Guilbert, Theresa W., Taussig, Lynn M., Wright, Anne L., Martinez, Fernando D.·2005·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/rccm.200504-525ocPMC PMC2718414
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Abstract

RATIONALE: The effect of early life wheezing on respiratory function and continued symptoms through adolescence has not been fully described. Using data from a population-based birth cohort in Tucson, Arizona, we previously described four phenotypes based on the occurrence of wheezing lower respiratory illnesses before age 3 yr and active wheeze at age 6 yr: never wheezers (n = 425), transient early wheezers (n = 164), persistent wheezers (n = 113), and late-onset wheezers (n = 124). OBJECTIVE: We sought to determine the prognosis for these phenotypes, with reference to lung function and symptoms, through adolescence. METHODS: Current wheeze was assessed by questionnaire, lung function was measured by conventional spirometry, and atopy was determined by skin prick tests. RESULTS: The prevalence of atopy and wheeze by age 16 yr was similar for never and transient wheezers and for persistent and late-onset wheezers. Both transient early, and persistent wheezers had significantly lower FEF(25-75) (-259 ml/s, p < 0.001, and -260 ml/s, p = 0.001, respectively), FEV1 (-75 ml, p = 0.02, and -87 ml, p = 0.03, respectively), and FEV1:FVC ratio (-1.9%, p = 0.002, and -2.5%, p = 0.001, respectively) through age 16 yr compared with never wheezers. Late-onset wheezers had levels of lung function similar to those of never wheezers through age 16 yr. There was no significant change in lung function among subjects with any of the four phenotypes, relative to their peers, from age 6 to 16 yr. CONCLUSION: Patterns of wheezing prevalence and levels of lung function are established by age 6 yr and do not appear to change significantly by age 16 yr in children who start having asthma-like symptoms during the preschool years.

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Research works printed but not linked: 22

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  11. 1996, Am J Respir Crit Care Med, S208
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  13. 2002, Clin Exp Allergy, 51
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Metadata

Authors
Morgan, W. J., Stern, D. A., Sherrill, D. L., Guerra, S., Holberg, C. J., Guilbert, T. W., Taussig, L. M., Wright, A. L., & Martinez, F. D.
Affiliations
  • University of Arizona (US)
  • Arizona Respiratory Center and Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, Arizona; and National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, Colorado
ORCID
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
2005-11
Volume
172
Issue
10
Pages
1253-1258
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
DOI
10.1164/rccm.200504-525oc
PMC
PMC2718414
OpenAlex
W1979846404
Cited by
650
References
23
Citations by year
2026: 6 · 2025: 11 · 2024: 17 · 2023: 15 · 2022: 15 · 2021: 24 · 2020: 17 · 2019: 24 · 2018: 36 · 2017: 24 · 2016: 27 · 2015: 42 · 2014: 31 · 2013: 27 · 2012: 40
FWCI
29.77
Type
journal article
Language
en
Open access
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • American Journal of Respiratory and Critical Care Medicine (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (submittedVersion)
Funders
  • National Institutes of Health (5k14hl003154-02, 5p50hl014136-25, 14136)
  • National Heart, Lung, and Blood Institute (HL-14136, HL 03154, R01HL056177, HL-56177)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Keywords
wheezing phenotypes, persistent wheezing, lung function, respiratory function, atopy, asthma, adolescence, preschool wheeze, FEV1/FVC ratio
MeSH terms
Adolescent, Age Factors, Asthma, Child, Child, Preschool, Forced Expiratory Flow Rates, Humans, Immunoglobulin E, Phenotype, Prognosis, Respiratory Sounds

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