The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Do Inhaled Carbon Nanoparticles Translocate Directly into the Circulation in Humans?
Open accessAbstract
RATIONALE: Increased exposure to particulate air pollution (PM(10)) is a risk factor for death and hospitalization with cardiovascular disease. It has been suggested that the nanoparticulate component of PM(10) is capable of translocating into the circulation with the potential for direct effects on the vasculature. OBJECTIVE: The study's aim was to determine the extent to which inhaled technetium-99m ((99m)Tc)-labeled carbon nanoparticles (Technegas) were able to access the systemic circulation. METHODS AND MAIN RESULTS: Ten healthy volunteers inhaled Technegas and blood samples were taken sequentially over the following 6 h. Technegas particles were 4-20 nm in diameter and aggregated to a median particle diameter of approximately 100 nm. Radioactivity was immediately detected in blood, with levels increasing over 60 min. Thin-layer chromatography of whole blood identified a species that moved with the solvent front, corresponding to unbound (99m)Tc-pertechnetate, which was excreted in urine. There was no evidence of particle-bound (99m)Tc at the origin. gamma Camera images demonstrated high levels of Technegas retention (95.6 +/- 1.7% at 6 h) in the lungs, with no accumulation of radioactivity detected over the liver or spleen. CONCLUSIONS: The majority of (99m)Tc-labeled carbon nanoparticles remain within the lung up to 6 h after inhalation. In contrast to previous published studies, thin-layer chromatography did not support the hypothesis that inhaled Technegas carbon nanoparticles pass directly from the lungs into the systemic circulation.
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Citations
Cites
An association between air pollution and mortality in six U.S. cities
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Passage of inhaled particles into the blood circulation in humans
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Cited by
Brook, R. D., Rajagopalan, S., Pope, C. A., Brook, J. R., Bhatnagar, A., Diez-Roux, A. V., Holguin, F., Hong, Y., Luepker, R. V., Mittleman, M. A., et al. (2010) · Circulation · doi:10.1161/cir.0b013e3181dbece1 · Cited by 6,548
Nanomaterials and nanoparticles: Sources and toxicity
Buzea, C., Pacheco, I. I., & Robbie, K. (2007) · Biointerphases · doi:10.1116/1.2815690 · Cited by 3,789
Deposition and biokinetics of inhaled nanoparticles
Geiser, M., & Kreyling, W. G. (2010) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-7-2 · Cited by 747
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Self-citationKinetics of gold nanoparticles in the human placenta
Myllynen, P. K., Loughran, M. J., Howard, C. V., Sormunen, R., Walsh, A. A., & Vähäkangas, K. H. (2008) · Reproductive Toxicology · doi:10.1016/j.reprotox.2008.06.008 · Cited by 158
Saenen, N. D., Bové, H., Steuwe, C., Roeffaers, M. B. J., Provost, E. B., Lefebvre, W., Vanpoucke, C., Ameloot, M., & Nawrot, T. S. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201704-0797oc · Cited by 144
Semmler-Behnke, M., Lipka, J., Wenk, A., Hirn, S., Schäffler, M., Tian, F., Schmid, G., Oberdörster, G., & Kreyling, W. G. (2014) · Particle and Fibre Toxicology · doi:10.1186/s12989-014-0033-9 · Cited by 135
Nakane, H. (2012) · Environmental Health and Preventive Medicine · doi:10.1007/s12199-011-0252-8 · Cited by 101
Association between Green Space Structure and the Prevalence of Asthma: A Case Study of Toronto
Dong, Y., Liu, H., & Zheng, T. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18115852 · Cited by 24
Where Do Inhaled Fossil Fuel–derived Particles Go?
Grigg, J. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201707-1415ed · Cited by 5
(2008) · doi:10.1061/(asce)0893-1321(2008)21:4(266
(2008) · doi:10.1061/(asce)0893-1321(2008)21:4(272
Metadata
- Authors
- Mills, N. L., Amin, N., Robinson, S. D., Anand, A., Davies, J., Patel, D., de la Fuente, J. M., Cassee, F. R., Boon, N. A., MacNee, W., Millar, A. M., Donaldson, K., & Newby, D. E.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-02-15
- Volume
- 173
- Issue
- 4
- Pages
- 426-431
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2148313103
- Cited by
- 323
- References
- 3
- FWCI
- 17.19
- Type
- journal article
- Language
- en
- Open access
- green
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