The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Gender and Chronic Obstructive Pulmonary Disease: Why It Matters
Open accessAbstract
The prevalence of chronic obstructive pulmonary disease (COPD) in women is increasing, as is hospitalization for COPD. The number of women dying of COPD in the United States now surpasses men. Despite this, research suggests that physicians are still more likely to correctly diagnose men with COPD than women. Increased tobacco use in women likely explains some of the increase in the prevalence of COPD in women, but data suggest that women may actually be at greater risk of smoking-induced lung function impairment, more severe dyspnea, and poorer health status for the same level of tobacco exposure. The degree to which these observations represent biologic, physiologic, or sociologic differences is not known. Nonsmokers with COPD are also more likely to be female. In addition, new evidence is emerging that men and women may be phenotypically different in their response to tobacco smoke, with men being more prone to an emphysematous phenotype and women an airway predominant phenotype. Inasmuch as COPD is a disease of inflammation, it is also possible that sexual dimorphism of the human immune response may also be responsible for gender differences in the disease. More data are still needed on what the implications of these findings are on therapy. In this clinical commentary, we present current knowledge regarding how gender influences the epidemiology, diagnosis, and presentation of COPD in addition to physiologic and psychologic impairments and we attempt to offer insight into why these differences might exist and how this may influence therapeutic management.
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Cites
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Cited by
Characterisation of COPD heterogeneity in the ECLIPSE cohort
the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators, Agusti, A., Calverley, P. M., Celli, B., Coxson, H. O., Edwards, L. D., Lomas, D. A., MacNee, W., Miller, B. E., Rennard, S., et al. (2010) · Respiratory Research · doi:10.1186/1465-9921-11-122 · Cited by 1,157
Can AI Help Reduce Disparities in General Medical and Mental Health Care?
(2019) · AMA Journal of Ethics · doi:10.1001/amajethics.2019.167 · Cited by 401
Sakornsakolpat, P., Prokopenko, D., Lamontagne, M., Reeve, N. F., Guyatt, A. L., Jackson, V. E., Shrine, N., Qiao, D., Bartz, T. M., Kim, D. K., et al. (2019) · Nature Genetics · doi:10.1038/s41588-018-0342-2 · Cited by 384
Self-citationExacerbation rate, health status and mortality in COPD – a review of potential interventions
Seemungal, T. (2009) · International Journal of Chronic Obstructive Pulmonary Disease · doi:10.2147/copd.s3385 · Cited by 197
Prevalence, Incidence, and Lifetime Risk for the Development of COPD in the Elderly
van Durme, Y. M. T. A., Verhamme, K. M. C., Stijnen, T., van Rooij, F. J. A., Van Pottelberge, G. R., Hofman, A., Joos, G. F., Stricker, B. H. C., & Brusselle, G. G. (2009) · Chest · doi:10.1378/chest.08-0684 · Cited by 151
Metadata
- Authors
- Han, M. K., Postma, D., Mannino, D. M., Giardino, N. D., Buist, S., Curtis, J. L., & Martinez, F. J.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-12-15
- Volume
- 176
- Issue
- 12
- Pages
- 1179-1184
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2098628108
- Cited by
- 353
- References
- 44
- FWCI
- 14.06
- Type
- journal article
- Language
- en
- Open access
- green
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- Han, M. K., Postma, D., Mannino, D. M., Giardino, N. D., Buist, S., Curtis, J. L., & Martinez, F. J. (2007). Gender and Chronic Obstructive Pulmonary Disease: Why It Matters. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200704-553cc
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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