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Cited by 368

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

Extrapulmonary Effects of Chronic Obstructive Pulmonary Disease on Physical Activity: A Cross-sectional Study

Watz, Henrik, Waschki, Benjamin, Boehme, Corinna, Claussen, Martin, Meyer, Thorsten, Magnussen, Helgo·2008·American Journal of Respiratory and Critical Care Medicine

Abstract

RATIONALE: Physical activity is reduced in patients with chronic obstructive pulmonary disease (COPD). COPD has a systemic component that includes significant extrapulmonary effects that may contribute to its severity in individual patients. OBJECTIVES: To investigate the association of extrapulmonary effects of the disease and its comorbidities with reduced physical activity in patients with COPD. METHODS: In a cross-sectional study, 170 outpatients with COPD (GOLD [Global Initiative for Chronic Obstructive Lung Disease] stages I-IV; BODE [body mass index, airway obstruction, dyspnea, and exercise capacity] score 0-10) underwent a series of tests. Physical activity was assessed over 5 to 6 consecutive days by using a multisensor accelerometer armband that records steps per day and the physical activity level (total daily energy expenditure divided by whole-night sleeping energy expenditure). Cardiovascular status was assessed by echocardiography, vascular Doppler sonography, and levels of N-terminal pro-B-type natriuretic peptide. Mental status, metabolic/muscular status, systemic inflammation, and anemia were assessed by Beck Depression Inventory, bioelectrical impedance analysis, handgrip strength, high-sensitivity C-reactive protein/fibrinogen, and hemoglobin, respectively. MEASUREMENTS AND MAIN RESULTS: In a multivariate linear regression analysis using either steps per day or physical activity level as a dependent variable, the extrapulmonary parameters that were associated with reduced physical activity in patients with COPD independently of GOLD stages or BODE score were N-terminal pro-B-type natriuretic peptide levels, echocardiographically measured left ventricular diastolic function, and systemic inflammation. CONCLUSIONS: Higher values of systemic inflammation and left cardiac dysfunction are associated with reduced physical activity in patients with COPD.

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Metadata

Authors
Watz, H., Waschki, B., Boehme, C., Claussen, M., Meyer, T., & Magnussen, H.
Venue
American Journal of Respiratory and Critical Care Medicine
Published
2008-04-01
Volume
177
Issue
7
Pages
743-751
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
OpenAlex
W1892623219
Cited by
368
References
58
FWCI
16.40
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Extrapulmonary Effects of Chronic Obstructive Pulmonary Disease on Physical Activity: A Cross-sectional Study. https://app.cochat.ai/papers/10.1164/rccm.200707-1011oc
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Watz, H., Waschki, B., Boehme, C., Claussen, M., Meyer, T., & Magnussen, H. (2008). Extrapulmonary Effects of Chronic Obstructive Pulmonary Disease on Physical Activity: A Cross-sectional Study. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200707-1011oc

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