The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Anemia, Blood Loss, and Blood Transfusions in North American Children in the Intensive Care Unit
Abstract
RATIONALE: Minimizing exposure of children to blood products is desirable. OBJECTIVES: We aimed to understand anemia development, blood loss, and red blood cell (RBC) transfusions in the pediatric intensive care unit (PICU). METHODS: Prospective, multicenter, 6-month observational study in 30 PICUs. Data were collected on consecutive children (<18 yr old) in the PICU for 48 hours or more. MEASUREMENTS AND MAIN RESULTS: Anemia development, blood loss, and RBC transfusions were measured. A total of 977 children were enrolled. Most (74%) children were anemic in the PICU (33% on admission, 41% developed anemia). Blood draws accounted for 73% of daily blood loss; median loss was 5.0 ml/day. Forty-nine percent of children received transfusions; 74% of first transfusions were on Days 1-2. After adjusting for age and illness severity, compared with nontransfused children, children who underwent transfusion had significantly longer days of mechanical ventilation (2.1 d, P < 0.001) and PICU stay (1.8 d, P = 0.03), and had increased mortality (odds ratio [OR], 11.6; 95% confidence interval [CI], 1.43-90.9; P = 0.02), nosocomial infections (OR, 1.9; 95% CI, 1.2-3.0; P = 0.004), and cardiorespiratory dysfunction (OR, 2.1; 95% CI, 1.5-3.0; P < 0.001). High blood loss per kilogram body weight from blood draws (OR, 1.11; 95% CI, 1.03-1.2; P = 0.01) was associated with RBC transfusion more than 48 hours after admission. The most common indication for transfusion was low hemoglobin (42%). Pretransfusion hemoglobin values varied greatly (mean, 9.7 +/- 2.7 g/dl). CONCLUSIONS: Critically ill children are at significant risk for developing anemia and receiving blood transfusions. Transfusion in the PICU was associated with worse outcomes. It is imperative to minimize blood loss from blood draws and to set clear transfusion thresholds.
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Multiple Organ Dysfunction Score: A reliable descriptor of a complex clinical outcome
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Anemia and Blood Transfusion in Critically Ill Patients
Vincent, J. L. (2002) · JAMA · doi:10.1001/jama.288.12.1499 · Cited by 1,821
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Transfusion Strategies for Patients in Pediatric Intensive Care Units
Lacroix, J., Hébert, P. C., Hutchison, J. S., Hume, H. A., Tucci, M., Ducruet, T., Gauvin, F., Collet, J.-P., Toledano, B. J., Robillard, P., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa066240 · Cited by 1,085
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Efficacy and Safety of Epoetin Alfa in Critically Ill Patients
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Cited by
PELOD-2: An Update of the PEdiatric Logistic Organ Dysfunction Score
Leteurtre, S., Duhamel, A., Salleron, J., Grandbastien, B., Lacroix, J., & Leclerc, F. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31828a2bbd · Cited by 677
Self-citationGuidelines on transfusion for fetuses, neonates and older children
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Dalton, H. J., Reeder, R., Garcia-Filion, P., Holubkov, R., Berg, R. A., Zuppa, A., Moler, F. W., Shanley, T., Pollack, M. M., Newth, C., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201609-1945oc · Cited by 353
Hemophagocytosis causes a consumptive anemia of inflammation
Zoller, E. E., Lykens, J. E., Terrell, C. E., Aliberti, J., Filipovich, A. H., Henson, P. M., & Jordan, M. B. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20102538 · Cited by 228
Metadata
- Authors
- Bateman, S. T., Lacroix, J., Boven, K., Forbes, P., Barton, R., Thomas, N. J., Jacobs, B., Markovitz, B., Goldstein, B., Hanson, J. H., Li, H. A., & Randolph, A. G.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-07-01
- Volume
- 178
- Issue
- 1
- Pages
- 26-33
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2123470684
- Cited by
- 287
- References
- 30
- FWCI
- 8.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bateman, S. T., Lacroix, J., Boven, K., Forbes, P., Barton, R., Thomas, N. J., Jacobs, B., Markovitz, B., Goldstein, B., Hanson, J. H., Li, H. A., & Randolph, A. G. (2008). Anemia, Blood Loss, and Blood Transfusions in North American Children in the Intensive Care Unit. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200711-1637oc
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