The DOI matches its Crossref record; 38 of the 39 references it cites were found in a registry or an index.
IgE Sensitization to Aspergillus fumigatus Is Associated with Reduced Lung Function in Asthma
Open accessAbstract
RATIONALE: The importance of Aspergillus fumigatus sensitization and colonization of the airways in patients with asthma is unclear. OBJECTIVES: To define the relationship between the clinical and laboratory features of A. fumigatus-associated asthma. METHODS: We studied 79 patients with asthma (89% classed as GINA 4 or 5) classified into 3 groups according to A. fumigatus sensitization: (1) IgE-sensitized (immediate cutaneous reactivity > 3 mm and/or IgE > 0.35 kU/L); (2) IgG-only-sensitized (IgG > 40 mg/L); and (3) nonsensitized. These were compared with 14 healthy control subjects. Sputum culture was focused toward detection of A. fumigatus and compared with clinical assessment data. MEASUREMENTS AND MAIN RESULTS: A. fumigatus was cultured from 63% of IgE-sensitized patients with asthma (n = 40), 39% of IgG-only-sensitized patients with asthma (n = 13), 31% of nonsensitized patients with asthma (n = 26) and 7% of healthy control subjects (n = 14). Patients sensitized to A. fumigatus compared with nonsensitized patients with asthma had lower lung function (postbronchodilator FEV₁ % predicted, mean [SEM]: 68 [±5]% versus 88 [±5]%; P < 0.05), more bronchiectasis (68% versus 35%; P < 0.05), and more sputum neutrophils (median [interquartile range]: 80.9 [50.1-94.1]% versus 49.5 [21.2-71.4]%; P < 0.01). In a multilinear regression model, A. fumigatus-IgE sensitization and sputum neutrophil differential cell count were important predictors of lung function (P = 0.016), supported by culture of A. fumigatus (P = 0.046) and eosinophil differential cell count (P = 0.024). CONCLUSIONS: A. fumigatus detection in sputum is associated with A. fumigatus-IgE sensitization, neutrophilic airway inflammation, and reduced lung function. This supports the concept that development of fixed airflow obstruction in asthma is consequent upon the damaging effects of airway colonization with A. fumigatus.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
IgE sensitization to fungal species is associated with increased asthma severity, neutrophilic inflammation, and reduced lung function consistent with ACOS.
“IgE sensitization to fungal species is associated with increased asthma severity, neutrophilic inflammation, and reduced lung function consistent with ACOS (105).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [105]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
(2005) · PubMed · Cited by 7,011
Proceedings of the ATS Workshop on Refractory Asthma
(2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.6.ats9-00 · Cited by 912
Brightling, C. E., Monteiro, W. R., Ward, R. J., Parker, D., Morgan, M. D. L., Wardlaw, A. J., & Pavord, I. D. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02872-5 · Cited by 586
Self-citationA Randomized Trial of Itraconazole in Allergic Bronchopulmonary Aspergillosis
Stevens, D. A., Schwartz, H. J., Lee, J. Y., Moskovitz, B. L., Jerome, D. C., Catanzaro, A., Bamberger, D. M., Weinmann, A. J., Tuazon, C. U., Judson, M. A., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003163421102 · Cited by 530
Heterogeneity of Airway Inflammation in Persistent Asthma
Gibson, P. G., Simpson, J. L., & SALTOS, N. (2001) · CHEST Journal · doi:10.1378/chest.119.5.1329 · Cited by 528
Zureik, M., Neukirch, C., Leynaert, B., Liard, R., Bousquet, J., & Neukirch, F. (2002) · BMJ · doi:10.1136/bmj.325.7361.411 · Cited by 489
Allergic bronchopulmonary aspergillosis
Greenberger, P. A. (2002) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2002.130179 · Cited by 475
The use of induced sputum to investigate airway inflammation
Pavord, I. D., Pizzichini, M. M. M., Pizzichini, E., & Hargreave, F. E. (1997) · Thorax · doi:10.1136/thx.52.6.498 · Cited by 421
Self-citationRandomized Controlled Trial of Oral Antifungal Treatment for Severe Asthma with Fungal Sensitization
Denning, D. W., O’Driscoll, B. R., Powell, G., Chew, F., Atherton, G. T., Vyas, A., Miles, J., Morris, J., & Niven, R. M. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200805-737oc · Cited by 342
Wark, P. A. B., Hensley, M., SALTOS, N., Boyle, M. J., Toneguzzi, R., Epid, G. D. C., Simpson, J. L., McElduff, P., & Gibson, P. G. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.1388 · Cited by 298
Pizzichini, E., Pizzichini, M. M. M., Efthimiadis, A., Hargreave, F. E., & Dolovich, J. (1996) · European Respiratory Journal · doi:10.1183/09031936.96.09061174 · Cited by 298
Association Between Neutrophilic Airway Inflammation and Airflow Limitation in Adults With Asthma
Shaw, D. E., Berry, M. A., Hargadon, B., McKenna, S., Shelley, M., Green, R. H., Brightling, C. E., Wardlaw, A. J., & Pavord, I. D. (2007) · CHEST Journal · doi:10.1378/chest.07-1047 · Cited by 237
Self-citationAllergic bronchopulmonary aspergillosis
Tillie‐Leblond, I., & Tonnel, A. (2005) · Allergy · doi:10.1111/j.1398-9995.2005.00887.x · Cited by 189
Bakare, N., Rickerts, V., Bargon, J., & Just‐Nübling, G. (2003) · Mycoses · doi:10.1046/j.1439-0507.2003.00830.x · Cited by 183
Identification of Pathogenic Fungi
Campbell, C. K., Johnson, E. M., & Warnock, D. W. (2013) · Wiley eBooks · doi:10.1002/9781118520055 · Cited by 180
Effect of Allergic Bronchopulmonary Aspergillosis on Lung Function in Children with Cystic Fibrosis
Kraemer, R., Deloséa, N., Ballinari, P., Gallati, S., & Crameri, R. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200603-423oc · Cited by 179
Nonreversible airflow obstruction in life‐long nonsmokers with moderate to severe asthma
Ulrik, C. S., & Backer, V. (1999) · European Respiratory Journal · doi:10.1034/j.1399-3003.1999.14d27.x · Cited by 174
O'Driscoll, B. R., Powell, G., Chew, F., Niven, R. M., Miles, J. F., Vyas, A., & Denning, D. W. (2009) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2009.03339.x · Cited by 166
Azoles for allergic bronchopulmonary aspergillosis associated with asthma
Wark, P. A. B., Gibson, P. G., & Wilson, A. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001108.pub2 · Cited by 147
113 Bronchoalveolar lavage in allergic bronchopulmonary aspergillosis (ABPA)
Greenberger, P., Smith, L. J., Roberts, M. S., & Liotta, J. L. (1985) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(85)90248-9 · Cited by 145
Maurya, V., Gugnani, H. C. C., Sarma, P. U., Madan, T., & Shah, A. (2005) · CHEST Journal · doi:10.1016/s0012-3692(15)34474-3 · Cited by 130
Little, S. A., MacLeod, K. J., Chalmers, G. W., Love, J. G., McSharry, C. P., & Thomson, N. C. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01047-1 · Cited by 112
Allergic Bronchopulmonary Aspergillosis in the Asthma Clinic
Eaton, T. E., Garrett, J., Milne, D. G., Frankel, A., & Wells, A. U. (2000) · CHEST Journal · doi:10.1378/chest.118.1.66 · Cited by 111
Schwartz, H. J., Citron, K. M., Chester, E. H., Kaimal, J., Barlow, P. B., Baum, G. L., & Schuyler, M. R. (1978) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(78)90065-9 · Cited by 106
Pathophysiology and immunology of allergic bronchopulmonary aspergillosis
Moss, R. B. (2005) · Medical Mycology · doi:10.1080/13693780500052255 · Cited by 101
Immunopathogenesis of allergic bronchopulmonary aspergillosis and airway remodeling
Kauffman, H. F. (2003) · Frontiers in bioscience · doi:10.2741/990 · Cited by 91
Sensitization to Aspergillus Fumigatus and Lung Function in Children With Cystic Fibrosis
Wojnarowski, C., Eichler, I., Gärtner, C., Götz, M., Renner, S., Koller, D. Y., & Frischer, T. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.6.9196093 · Cited by 81
Maurya, V. (2005) · CHEST Journal · doi:10.1378/chest.127.4.1252 · Cited by 73
Diaphragm pacing restores olfaction in tetraplegia
Adler, D., Gonzalez‐Bermejo, J., Duguet, A., Demoule, A., Pimpec‐Barthes, F. L., Hurbault, A., Morélot‐Panzini, C., & Similowski, T. (2009) · European Respiratory Journal · doi:10.1183/09031936.00177708 · Cited by 63
Azoles for allergic bronchopulmonary aspergillosis associated with asthma
Wark, P. A. B., Gibson, P. G., & Wilson, A. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001108 · Cited by 63
Chotirmall, S. H., Branagan, P., Gunaratnam, C., & McElvaney, N. G. (2008) · Respiratory Care · doi:10.4187/respcare.08531035 · Cited by 46
Quantitative sputum cell counts as a marker of airway inflammation in clinical practice
Hargreave, F. E. (2007) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e328013e3c2 · Cited by 44
Allergie Bronchopulmonary Aspergillosis: A Review
Wardlaw, A. J., & Geddes, D. M. (1992) · Journal of the Royal Society of Medicine · doi:10.1177/014107689208501212 · Cited by 26
Self-citationDolan, C. T. (1971) · Applied Microbiology · doi:10.1128/am.21.2.195-197.1971 · Cited by 12
Dolan, C. T. (1971) · Applied Microbiology · doi:10.1128/aem.21.2.195-197.1971 · Cited by 7
Randhawa, H. S., Kowshik, T., Sinha, K. P., Sandhu, R., & Chowdhary, A. (2005) · Cited by 6
228 Prevalence of aspergillus/allergic bronchopulmonary aspergillosis in a CF population
Chotirmall, S. H., Branagan, P., Lyons, A. M., Low, T. B., & McElvaney, N. G. (2006) · Journal of Cystic Fibrosis · doi:10.1016/s1569-1993(06)80210-9 · Cited by 2
Aspergillus in Sputum Culture – Infection or Colonisation.
Datta, B., Barton, R., Hobson, R. P., & McLaughlin, H. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a5943 · Cited by 2
Flagged first, then by citations
1 of the 39 references couldn’t be matched to a known paper.
Research works printed but not linked: 34
- 2000, Chest, 66
- 2006, Am J Respir Crit Care Med, 1211
- 2008, National Standard Method BSOP, 1
- 2002, J Allergy Clin Immunol, 685
- 2005, Allergy, 1004
- 1992, J R Soc Med, 747
- 2000, N Engl J Med, 756
- 2003, J Allergy Clin Immunol, 952
- 2009, Cochrane Database Syst Rev, CD001108
- 2009, Am J Respir Crit Care Med, 11
- 2009, Eur Respir J, 365
- 2009, Clin Exp Allergy, 1946
- 2000, Am J Respir Crit Care Med, 2341
- 2000, Lancet, 1480
- 1996, Eur Respir J, 1174
- 1997, Thorax, 498
- 2005, Fam Med, 360
- 2009, Clin Exp Allergy, 1677
- 1978, J Allergy Clin Immunol, 9
- 2002, BMJ, 411
- 1997, Am J Respir Crit Care Med, 1902
- 2008, Respir Care, 1035
- 1999, Eur Respir J, 892
- 2007, Chest, 1871
- 2002, Am J Med, 446
- 2005, Chest, 1252
- 2003, Front Biosci, e190
- 2003, Mycoses, 19
- 1971, Appl Microbiol, 195
- 2005, Curr Sci, 449
- 2005, Med Mycol, S203
- 2009, Am J Respir Crit Care Med, A5943
- 2007, Curr Opin Allergy Clin Immunol, 102
- 2001, Chest, 1329
Cited by
Sorted by citations
Hidden Killers: Human Fungal Infections
Brown, G. D., Denning, D. W., Gow, N. A. R., Levitz, S. M., Netea, M. G., & White, T. C. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004404 · Cited by 4,284
Epidemiology of Asthma in Children and Adults
Dharmage, S. C., Perret, J. L., & Custovic, A. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00246 · Cited by 1,200
Agarwal, R., Chakrabarti, A., Shah, A., Gupta, D., Meis, J. F., Guleria, R., Moss, R., Denning, D. W., & ABPA complicating asthma ISHAM working group (2013) · Clinical & Experimental Allergy · doi:10.1111/cea.12141 · Cited by 896
Fungi and allergic lower respiratory tract diseases
Knutsen, A. P., Bush, R. K., Demain, J. G., Denning, D. W., Dixit, A., Fairs, A., Greenberger, P. A., Kariuki, B., Kita, H., Kurup, V. P., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.12.970 · Cited by 486
Self-citationA Large Subgroup of Mild-to-Moderate Asthma Is Persistently Noneosinophilic
McGrath, K. W., Icitovic, N., Boushey, H. A., Lazarus, S. C., Sutherland, E. R., Chinchilli, V. M., & Fahy, J. V. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201109-1640oc · Cited by 485
Fungal allergy in asthma-state of the art and research needs
Denning, D. W., Pashley, C., Hartl, D., Wardlaw, A., Godet, C., Del Giacco, S., Delhaes, L., & Sergejeva, S. (2014) · Clinical and Translational Allergy · doi:10.1186/2045-7022-4-14 · Cited by 357
Self-citationDenning, D. W., Park, S., Lass-Florl, C., Fraczek, M. G., Kirwan, M., Gore, R., Smith, J., Bueid, A., Moore, C. B., Bowyer, P., et al. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir179 · Cited by 313
Geographic variation in the aetiology, epidemiology and microbiology of bronchiectasis
Chandrasekaran, R., Aogáin, M. M., Chalmers, J. D., Elborn, J. S., & Chotirmall, S. H. (2018) · BMC Pulmonary Medicine · doi:10.1186/s12890-018-0638-0 · Cited by 271
T cell homing to epithelial barriers in allergic disease
Islam, S. A., & Luster, A. D. (2012) · Nature Medicine · doi:10.1038/nm.2760 · Cited by 222
Sensitization to fungal allergens: Resolved and unresolved issues
Fukutomi, Y., & Taniguchi, M. (2015) · Allergology International · doi:10.1016/j.alit.2015.05.007 · Cited by 220
Novel immunologic classification of aspergillosis in adult cystic fibrosis
Baxter, C. G., Dunn, G., Jones, A. M., Webb, A. K., Gore, R. B., Richardson, M. D., & Denning, D. W. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.04.007 · Cited by 213
Severe adult-onset asthma: A distinct phenotype
Amelink, M., de Groot, J. C., de Nijs, S. B., Lutter, R., Zwinderman, A. H., Sterk, P. J., Brinke, A. T., & Bel, E. H. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.04.052 · Cited by 216
Allergic Bronchopulmonary Aspergillosis in Asthma and Cystic Fibrosis
Knutsen, A. P., & Slavin, R. G. (2011) · Clinical and Developmental Immunology · doi:10.1155/2011/843763 · Cited by 209
Severe asthma with fungal sensitization
Agarwal, R. (2011) · Current Allergy and Asthma Reports · doi:10.1007/s11882-011-0217-4 · Cited by 188
Clinical Efficacy and Immunologic Effects of Omalizumab in Allergic Bronchopulmonary Aspergillosis
Voskamp, A. L., Gillman, A., Symons, K., Sandrini, A., Rolland, J. M., O’Hehir, R. E., & Douglass, J. A. (2015) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2014.12.008 · Cited by 184
Agarwal, R., Maskey, D., Aggarwal, A. N., Saikia, B., Garg, M. K., Gupta, D., & Chakrabarti, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061105 · Cited by 173
Aspergillus fumigatus during stable state and exacerbations of COPD
Bafadhel, M., McKenna, S., Agbetile, J., Fairs, A., Desai, D., Mistry, V., Morley, J. P., Pancholi, M., Pavord, I. D., Wardlaw, A. J., et al. (2013) · European Respiratory Journal · doi:10.1183/09031936.00162912 · Cited by 165
Self-citationAspergillus sensitization is associated with airflow limitation and bronchiectasis in severe asthma
Menzies, D., Holmes, L. J., McCumesky, G., Prys-Picard, C. O., & Niven, R. M. (2011) · Allergy · doi:10.1111/j.1398-9995.2010.02542.x · Cited by 159
Mast cells in asthma – state of the art
Bradding, P., & Arthur, G. K. (2015) · Clinical & Experimental Allergy · doi:10.1111/cea.12675 · Cited by 164
Self-citationAllergic bronchopulmonary aspergillosis
Agarwal, R., Sehgal, I. S., Dhooria, S., Muthu, V., Prasad, K., Bal, A., Aggarwal, A., & Chakrabarti, A. (2020) · The Indian Journal of Medical Research · doi:10.4103/ijmr.ijmr_1187_19 · Cited by 157
Chishimba, L., Niven, R. M., Cooley, J. D., & Denning, D. W. (2012) · Journal of Asthma · doi:10.3109/02770903.2012.662568 · Cited by 145
S2k-Leitlinie zur Diagnostik und Therapie von Patienten mit Asthma
Deutsche Gesellschaft für Arbeitsmedizin und Umweltmedizin e., V., Buhl, R., Bals, R., Baur, X., Berdel, D., Criée, C.-P., Gappa, M., Gillissen, A., Greulich, T., Haidl, P., et al. (2017) · Pneumologie · doi:10.1055/s-0043-119504 · Cited by 146
Albacker, L. A., Chaudhary, V., Chang, Y.-J., Kim, H. Y., Chuang, Y.-T., Pichavant, M., DeKruyff, R. H., Savage, P. B., & Umetsu, D. T. (2013) · Nature Medicine · doi:10.1038/nm.3321 · Cited by 140
The β-Glucan Receptor Dectin-1 Promotes Lung Immunopathology during Fungal Allergy via IL-22
Lilly, L. M., Gessner, M. A., Dunaway, C. W., Metz, A. E., Schwiebert, L., Weaver, C. T., Brown, G. D., & Steele, C. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201797 · Cited by 130
Lung damage and airway remodelling in severe asthma
Brightling, C. E., Gupta, S., Gonem, S., & Siddiqui, S. (2011) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2011.03917.x · Cited by 129
Self-citationPashley, C. H., Fairs, A., Morley, J. P., Tailor, S., Agbetile, J., Bafadhel, M., Brightling, C. E., & Wardlaw, A. J. (2012) · Medical Mycology · doi:10.3109/13693786.2011.615762 · Cited by 116
Self-citationNETopathic Inflammation in Chronic Obstructive Pulmonary Disease and Severe Asthma
Uddin, M., Watz, H., Malmgren, A., & Pedersen, F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00047 · Cited by 116
Agbetile, J., Fairs, A., Desai, D., Hargadon, B., Bourne, M., Mutalithas, K., Edwards, R., Morley, J. P., Monteiro, W. R., Kulkarni, N. S., et al. (2012) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2012.03987.x · Cited by 111
Self-citationAspergillus-Associated Airway Disease, Inflammation, and the Innate Immune Response
Chotirmall, S. H., Al‐Alawi, M., Mirković, B., Lavelle, G., Logan, P. M., Greene, C. M., & McElvaney, N. G. (2013) · BioMed Research International · doi:10.1155/2013/723129 · Cited by 117
OX40/OX40 Ligand Interactions in T-Cell Regulation and Asthma
Kaur, D., & Brightling, C. E. (2012) · CHEST Journal · doi:10.1378/chest.11-1730 · Cited by 114
Self-citationAllergic aspergillosis of the respiratory tract
Shah, A., & Panjabi, C. (2014) · European Respiratory Review · doi:10.1183/09059180.00007413 · Cited by 106
The global impact of Aspergillus infection on COPD
Hammond, E. E., McDonald, C. S., Vestbo, J., & Denning, D. W. (2020) · BMC Pulmonary Medicine · doi:10.1186/s12890-020-01259-8 · Cited by 111
Kerzerho, J., Maazi, H., Speak, A. O., Szely, N., Lombardi, V., Khoo, B., Geryak, S., Lam, J., Soroosh, P., Snick, J. V., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.09.027 · Cited by 101
Severe asthma—A population study perspective
Bäckman, H., Jansson, S., Stridsman, C., Eriksson, B., Hedman, L., Eklund, B., Sandström, T., Lindberg, A., Lundbäck, B., & Rönmark, E. (2019) · Clinical & Experimental Allergy · doi:10.1111/cea.13378 · Cited by 107
Aspergillus bronchitis without significant immunocompromise
Chrdle, A., Mustakim, S., Bright-Thomas, R. J., Baxter, C. G., Felton, T., & Denning, D. W. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06816.x · Cited by 98
Treatment options in severe fungal asthma and allergic bronchopulmonary aspergillosis
Moss, R. B. (2013) · European Respiratory Journal · doi:10.1183/09031936.00139513 · Cited by 95
Sensitization to Aspergillus species is associated with frequent exacerbations in severe asthma
Goh, K. J., Yii, A. C. A., Lapperre, T. S., Chan, A., Chew, F. T., Chotirmall, S. H., & Koh, M. S. (2017) · Journal of Asthma and Allergy · doi:10.2147/jaa.s130459 · Cited by 91
Agbetile, J., Bourne, M., Fairs, A., Hargadon, B., Desai, D., Broad, C., Morley, J. P., Bradding, P. H., Brightling, C. E., Green, R. H., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.09.050 · Cited by 87
Self-citationClinical reviews in allergy and immunology
Leung, D. Y. M., Ledford, D. K., Wechsler, M. E., Fulkerson, P. C., Bochner, B. S., Gauvreau, G. M., Gleich, G. J., Henkel, T., Kolbeck, R., Mathur, S. K., et al. (2012) · Cited by 87
Self-citationImpact of Aspergillus fumigatus in allergic airway diseases
Chaudhary, N., & Marr, K. A. (2011) · Clinical and Translational Allergy · doi:10.1186/2045-7022-1-4 · Cited by 86
Agarwal, R., Dua, D., Choudhary, H., Aggarwal, A. N., Sehgal, I. S., Dhooria, S., Garg, M. K., Behera, D., & Chakrabarti, A. (2016) · Mycoses · doi:10.1111/myc.12541 · Cited by 89
Baxter, C. G., Moore, C. B., Jones, A. M., Webb, A. K., & Denning, D. W. (2013) · CHEST Journal · doi:10.1378/chest.12-1363 · Cited by 82
Environmental fungal sensitisation associates with poorer clinical outcomes in COPD
Tiew, P. Y., Ko, F. W. S., Pang, S. L., Matta, S. A., Sio, Y. Y., Poh, M. E., Lau, K. J. X., Aogáin, M. M., Jaggi, T. K., Ivan, F. X., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.00418-2020 · Cited by 83
The relationship between biomarkers of fungal allergy and lung damage in asthma
Woolnough, K., Richardson, M., Newby, C., Craner, M., Bourne, M., Monteiro, W. R., Siddiqui, S., Bradding, P., Pashley, C. H., & Wardlaw, A. J. (2016) · Clinical & Experimental Allergy · doi:10.1111/cea.12848 · Cited by 78
Self-citationPathogenesis, imaging and clinical characteristics of CF and non-CF bronchiectasis
Schäfer, J. F., Griese, M., Chandrasekaran, R., Chotirmall, S. H., & Hartl, D. (2018) · BMC Pulmonary Medicine · doi:10.1186/s12890-018-0630-8 · Cited by 75
S2k-Leitlinie zur fachärztlichen Diagnostik und Therapie von Asthma 2023
Lommatzsch, M., Criée, C.-P., de Jong, C. C. M., Gappa, M., Geßner, C., Gerstlauer, M., Hämäläinen, N., Haidl, P., Hamelmann, E. H., Horak, F., et al. (2023) · Pneumologie · doi:10.1055/a-2070-2135 · Cited by 83
The Fungal Microbiome and Asthma
Bernardes, E. V. T., Gutierrez, M. W., & Arrieta, M. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.583418 · Cited by 70
Exacerbations of severe asthma
McDonald, V. M., & Gibson, P. G. (2012) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2012.03981.x · Cited by 72
Máiz, L., Vendrell, M., Olveira, C., Girón, R., Nieto, R., & Martínez-García, M. Á. (2015) · Respiration · doi:10.1159/000381289 · Cited by 69
Fungal sensitization in childhood persistent asthma is associated with disease severity
Vicencio, A. G., Santiago, M. T., Tsirilakis, K., Stone, A., Worgall, S., Foley, E. A., Bush, D. S., & Goldman, D. L. (2013) · Pediatric Pulmonology · doi:10.1002/ppul.22779 · Cited by 69
Bronchiectasis in severe asthma
Coman, I., Pola-Bibian, B., Barranco, P., Vilà-Nadal, G., Domínguez‐Ortega, J., Romero, D., Villasante, C., & Quirce, S. (2018) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2018.02.016 · Cited by 69
Muthu, V., Sehgal, I. S., Dhooria, S., Aggarwal, A. N., & Agarwal, R. (2018) · Clinical & Experimental Allergy · doi:10.1111/cea.13216 · Cited by 68
Innate immunity in the lung regulates the development of asthma
DeKruyff, R. H., Yu, S., Kim, H. Y., & Umetsu, D. T. (2014) · Immunological Reviews · doi:10.1111/imr.12187 · Cited by 68
Agarwal, R., Muthu, V., Sehgal, I. S., Dhooria, S., Prasad, K. T., Kathirvel, S., Rudramurthy, S. M., Aggarwal, A. N., & Chakrabarti, A. (2023) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2023.04.009 · Cited by 67
New Perspectives in the Diagnosis and Management of Allergic Fungal Airway Disease
Wardlaw, A. J., Rick, E., Özyiğit, L. P., Scadding, A., Gaillard, E. A., & Pashley, C. H. (2021) · Journal of Asthma and Allergy · doi:10.2147/jaa.s251709 · Cited by 67
Self-citationGuinea, J., Padilla, C., Escribano, P., Muñóz, P., Padilla, B., Gijón, P., & Bouza, E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061545 · Cited by 67
Serological diagnosis of allergic bronchopulmonary mycosis: Progress and challenges
Fukutomi, Y., 谷本, 英., Yasueda, H., & Taniguchi, M. (2015) · Allergology International · doi:10.1016/j.alit.2015.08.004 · Cited by 63
Allergic fungal airway disease
Woolnough, K., Fairs, A., Pashley, C. H., & Wardlaw, A. J. (2014) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0000000000000129 · Cited by 66
Self-citationBurden of fungal asthma in Africa: A systematic review and meta-analysis
Kwizera, R., Musaazi, J., Meya, D. B., Worodria, W. O., Bwanga, F., Kajumbula, H., Fowler, S. J., Kirenga, B., Gore, R. B., & Denning, D. W. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216568 · Cited by 63
Effects of Aspergillus fumigatus colonization on lung function in cystic fibrosis
Speirs, J. J., van der Ent, C. K., & Beekman, J. M. (2012) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e328358d50b · Cited by 68
Airway Microbiota and the Implications of Dysbiosis in Asthma
Durack, J., Boushey, H. A., & Lynch, S. V. (2016) · Current Allergy and Asthma Reports · doi:10.1007/s11882-016-0631-8 · Cited by 62
Asthma and allergy development: contrasting influences of yeasts and other fungal exposures
Behbod, B., Sordillo, J. E., Hoffman, E. B., Datta, S., Webb, T. E., Kwan, D., Kamel, J., Muilenberg, M. L., Scott, J. A., Chew, G. L., et al. (2014) · Clinical & Experimental Allergy · doi:10.1111/cea.12401 · Cited by 60
Occupational Exposure toAspergillusby Swine and Poultry Farm Workers in Portugal
Sabino, R., Faísca, V. M., Carolino, E., Veríssimo, C., & Viegas, C. (2012) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2012.721170 · Cited by 59
Inhaled drug delivery for the targeted treatment of asthma
Boboltz, A., Kumar, S., & Duncan, G. A. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114858 · Cited by 61
Relationship between Aspergillus and asthma
Agarwal, R., Muthu, V., & Sehgal, I. S. (2023) · Allergology International · doi:10.1016/j.alit.2023.08.004 · Cited by 58
Muthu, V., Singh, P. K., Choudhary, H., Sehgal, I. S., Dhooria, S., Prasad, K. T., Aggarwal, A. N., Garg, M. K., Chakrabarti, A., & Agarwal, R. (2019) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2019.08.041 · Cited by 56
Fungal Sensitization Is Associated with Increased Risk of Life-Threatening Asthma
Medrek, S. K., Kao, C. C., Yang, D. H., Hanania, N. A., & Parulekar, A. D. (2016) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2016.11.015 · Cited by 56
High Frequency of Allergic Bronchopulmonary Aspergillosis in Bronchiectasis-COPD Overlap
Tiew, P. Y., Lim, A. Y. H., Keir, H. R., Dicker, A., Aogáin, M. M., Pang, S. L., Low, T. B., Hassan, T. M., Poh, M. E., Xu, H., et al. (2021) · CHEST Journal · doi:10.1016/j.chest.2021.07.2165 · Cited by 55
The Role of Allergy in Severe Asthma
Kennedy, J. L., Heymann, P. W., & Platts‐Mills, T. A. E. (2012) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2011.03944.x · Cited by 55
Wan, W.-Y. H., Hollins, F., Haste, L., Woodman, L., Hirst, R. A., Bolton, S. J., Gomez, E., Sutcliffe, A., Desai, D., Chachi, L., et al. (2016) · CHEST Journal · doi:10.1016/j.chest.2016.01.024 · Cited by 55
Self-citationHigh‐altitude treatment: a therapeutic option for patients with severe, refractory asthma?
Rijssenbeek‐Nouwens, L. H., & Bel, E. H. (2011) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2011.03733.x · Cited by 53
The airway fungal microbiome in asthma
Rick, E., Woolnough, K., Seear, P. J., Fairs, A., Satchwell, J., Richardson, M., Monteiro, W. R., Craner, M., Bourne, M., Wardlaw, A. J., et al. (2020) · Clinical & Experimental Allergy · doi:10.1111/cea.13722 · Cited by 53
Self-citationChotirmall, S. H., & Martín-Gómez, M. T. (2017) · Mycopathologia · doi:10.1007/s11046-017-0143-7 · Cited by 52
Homogenisation of cystic fibrosis sputum by sonication — An essential step for Aspergillus PCR
Baxter, C. G., Jones, A. M., Webb, A. K., & Denning, D. W. (2011) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2011.01.024 · Cited by 49
Kespohl, S., Maryska, S., Zahradnik, E., Sander, I., Brüning, T., & Raulf, M. (2013) · Clinical & Experimental Allergy · doi:10.1111/cea.12186 · Cited by 49
Allergic fungal airways disease (AFAD): an under-recognised asthma endotype
Pashley, C. H., & Wardlaw, A. J. (2021) · Mycopathologia · doi:10.1007/s11046-021-00562-0 · Cited by 48
Self-citationSevere asthma and bronchiectasis
Clemente, M. M. G., Enríquez-Rodríguez, A. I., Urrutia, M. Í., Escobar-Mallada, B., Arias-Guillén, M., López‐González, F., Madrid-Carbajal, C. J., Martínez, L. P., & Budiño, T. G. (2019) · Journal of Asthma · doi:10.1080/02770903.2019.1579832 · Cited by 48
Current treatment of severe asthma
Hashimoto, S., & Bel, E. H. (2011) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2011.03936.x · Cited by 48
Jaggi, T. K., Agarwal, R., Tiew, P. Y., Shah, A., Lydon, E., Hage, C. A., WATERER, G. W., Langelier, C., Delhaès, L., & Chotirmall, S. H. (2024) · European Respiratory Journal · doi:10.1183/13993003.00803-2024 · Cited by 52
Farrant, J., Brice, H., Fowler, S. J., & Niven, R. M. (2016) · Journal of Asthma · doi:10.3109/02770903.2016.1154073 · Cited by 45
Airway mycosis in allergic airway disease
Li, E., Knight, J. M., Wu, Y., Luong, A., Rodríguez, A., Kheradmand, F., & Corry, D. B. (2019) · Advances in immunology · doi:10.1016/bs.ai.2019.05.002 · Cited by 45
Development of chronic pulmonary aspergillosis in adult asthmatics with ABPA
Lowes, D., Chishimba, L., Greaves, M., & Denning, D. W. (2015) · Respiratory Medicine · doi:10.1016/j.rmed.2015.09.007 · Cited by 43
Eosinophils in fungal diseases: An overview
Figueiredo, R. T., & Neves, J. S. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.4mr1117-473r · Cited by 43
Managing comorbid conditions in severe asthma
Bardin, P. G., Rangaswamy, J., & Yo, S. W. (2018) · The Medical Journal of Australia · doi:10.5694/mja18.00196 · Cited by 42
Mistry, H. M., Soberanis, H. M. A., Kyyaly, A., Azim, A., Barber, C., Knight, D., Newell, C., Haitchi, H. M., Wilkinson, T. M. A., Howarth, P. H., et al. (2021) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2021.08.038 · Cited by 41
Fairs, A., Agbetile, J., Bourne, M., Hargadon, B., Monteiro, W. R., Morley, J. P., Edwards, R., Wardlaw, A. J., & Pashley, C. H. (2012) · Indoor Air · doi:10.1111/ina.12020 · Cited by 41
Self-citationPashley, C. H. (2014) · Mycopathologia · doi:10.1007/s11046-014-9804-y · Cited by 40
Self-citationMinami, T., Fukutomi, Y., Inada, R., Tsuda, M., Sekiya, K., Miyazaki, M., Tsuji, F., & Taniguchi, M. (2019) · Allergology International · doi:10.1016/j.alit.2019.03.008 · Cited by 39
Targeting neutrophils in asthma: A therapeutic opportunity?
Volder, J. D., Vereecke, L., Joos, G., & Maes, T. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114292 · Cited by 39
Schlosser, O., Robert, S., & Debeaupuis, C. (2016) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2016.02.003 · Cited by 38
Management of allergic bronchopulmonary aspergillosis: a review and update
Mahdavinia, M., & Grammer, L. C. (2012) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753465812443094 · Cited by 38
Recent Insights into the Management of Inflammation in Asthma
Rupani, H., Fong, W. C. G., Kyyaly, A., & Kurukulaaratchy, R. J. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s295038 · Cited by 40
Non‐atopic males with adult onset asthma are at risk of persistent airflow limitation
Amelink, M., de Nijs, S. B., Berger, M., Weersink, E. J. M., Brinke, A. T., Sterk, P. J., & Bel, E. H. (2012) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2012.03977.x · Cited by 39
Phenotyping airways disease: an A to E approach
Gonem, S., Raj, V. J., Wardlaw, A. J., Pavord, I. D., Green, R., & Siddiqui, S. (2012) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2012.04008.x · Cited by 37
Self-citationPI3K inhibitor treatment ameliorates the glucocorticoid insensitivity of PBMCs in severe asthma
Bi, J., Min, Z., Yuan, H., Jiang, Z., Mao, R., Zhu, T., Liu, C., Zeng, Y., Song, J., Du, C., et al. (2020) · Clinical and Translational Medicine · doi:10.1186/s40169-020-0262-5 · Cited by 37
Aspergillus fumigatus Detection and Risk Factors in Patients with COPD–Bronchiectasis Overlap
Everaerts, S., Lagrou, K., Vermeersch, K., Dupont, L., Vanaudenaerde, B. M., & Janssens, W. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020523 · Cited by 36
Welsh, K. G., Holden, K. A., Wardlaw, A. J., Satchwell, J., Monteiro, W. R., Pashley, C. H., & Gaillard, E. A. (2020) · Clinical & Experimental Allergy · doi:10.1111/cea.13799 · Cited by 36
Self-citationRoy, R. M., Paes, H. C., Nanjappa, S. G., Sorkness, R. L., Gasper, D. J., Sterkel, A., Wüthrich, M., & Klein, B. S. (2013) · mBio · doi:10.1128/mbio.00162-13 · Cited by 35
Fungi in Cystic Fibrosis and Non–Cystic Fibrosis Bronchiectasis
Moss, R. B. (2015) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0035-1546750 · Cited by 34
The role of antifungals in the management of patients with severe asthma
Rapeport, G., Ito, K., & Denning, D. W. (2020) · Clinical and Translational Allergy · doi:10.1186/s13601-020-00353-8 · Cited by 35
Metadata
- Authors
- Fairs, A., Agbetile, J., Hargadon, B., Bourne, M., Monteiro, W. R., Brightling, C. E., Bradding, P., Green, R. H., Mutalithas, K., Desai, D., Pavord, I. D., Wardlaw, A. J., & Pashley, C. H.
- Affiliations
- University of Leicester (GB)
- ORCID
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-12-01
- Volume
- 182
- Issue
- 11
- Pages
- 1362-1368
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- PMC
- PMC3029929
- OpenAlex
- W2034519404
- Cited by
- 252
- References
- 39
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 14 · 2023: 10 · 2022: 9 · 2021: 17 · 2020: 26 · 2019: 20 · 2018: 18 · 2017: 16 · 2016: 10 · 2015: 15 · 2014: 15 · 2013: 19 · 2012: 28
- FWCI
- 14.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Leicester Research Archive (University of Leicester) (submittedVersion)
- Funders
- Wellcome Trust (082265)
- Midlands Asthma and Allergy Research Association
- European Regional Development Fund
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Keywords
- Aspergillus fumigatus, asthma, lung function, bronchiectasis, sputum neutrophils, eosinophils, airway colonization, IgE sensitization, IgG sensitization, FEV1, sputum culture, allergic asthma, non-allergic asthma, airway inflammation, bronchodilator response, eosinophilic asthma
- MeSH terms
- Adult, Aspergillus fumigatus, Asthma, Bronchiectasis, Female, Forced Expiratory Volume, Humans, Hypersensitivity, Immediate, Immunoglobulin E, Lung, Male, Middle Aged, Neutrophils, Respiratory Function Tests, Severity of Illness Index, Sputum, Cohort Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
