Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 194

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Circulating Endothelial Microparticles as a Measure of Early Lung Destruction in Cigarette Smokers

Gordon, Cynthia, Gudi, Kirana, Krause, Anja, Sackrowitz, Rachel, Harvey, Ben-Gary, Strulovici-Barel, Yael, Mezey, Jason G, Crystal, Ronald G·2011·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/rccm.201012-2061oc
Open this paper in CoChat — free account

Abstract

Rationale: There is increasing evidence that emphysema is associated with primary loss of pulmonary capillary endothelium. Plasma levels of endothelial microparticles (EMPs), small vesicles released from activated or apoptotic endothelial cells, are elevated in vascular-related disorders. Objectives: To evaluate whether plasma EMP levels are elevated in smokers with early lung destruction as assessed by normal spirometry but reduced diffusing capacity of the lung for carbon monoxide (Dlco). Methods: Lung health was assessed by pulmonary function tests (PFTs: spirometry, total lung capacity, Dlco) and chest X-ray; smoking status was assessed by urine nicotine and cotinine. EMP levels (CD42b−CD31+ microparticles) were quantified as activated or apoptotic. The initial cohort (n = 92) included healthy nonsmokers (normal PFTs), healthy smokers (normal PFTs), and smokers with early evidence of lung destruction (normal spirometry, low Dlco). Two prospective cohorts were then tested: a group similar to the initial cohort and an HIV1+ cohort. Measurements and Main Results: Healthy smokers had mildly increased levels of EMPs. Strikingly, 95% of smokers with normal spirometry, low Dlco had increased EMPs, with reduced CD62+/CD31+ ratios (P < 10−4) and elevated CD42b−CD31+ annexin V+ EMPs (P < 10−4), suggesting derivation from endothelial apoptosis. Most elevated EMPs were angiotensin-converting enzyme positive, suggesting derivation from pulmonary capillaries. Both prospective cohorts confirmed the initial cohort data. Conclusions: Plasma EMPs with apoptotic characteristics are elevated in smokers with normal spirometry but reduced Dlco, consistent with the concept that emphysema is associated, in part, with capillary endothelium apoptosis, suggesting that the early development of emphysema might be monitored with plasma EMP levels.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1164/rccm.201012-2061oc

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 3 references

Research works printed but not linked: 87

  1. Weibel, 1973, Morphological basis of alveolar-capillary gas exchange, Physiol Rev, 53, 419, 10.1152/physrev.1973.53.2.419 · DOI
  2. Hogg, 2002, Chronic obstructive pulmonary disease - part 2: pathology and biochemistry of emphysema, Thorax, 57, 830, 10.1136/thorax.57.9.830 · DOI
  3. Barnes, 2004, Mediators of chronic obstructive pulmonary disease, Pharmacol Rev, 56, 515, 10.1124/pr.56.4.2 · DOI
  4. Spurzem, 2005, Pathogenesis of COPD, Semin Respir Crit Care Med, 26, 142, 10.1055/s-2005-869535 · DOI
  5. Abboud, 2008, Pathogenesis of COPD. Part I. The role of protease-antiprotease imbalance in emphysema, Int J Tuberc Lung Dis, 12, 361
  6. Roth, 2008, Pathogenesis of COPD. Part III. Inflammation in COPD, Int J Tuberc Lung Dis, 12, 375
  7. Kasahara, 2000, Expression of 15-lipoxygenase and evidence for apoptosis in the lungs from patients with COPD, Chest, 117, 260S, 10.1378/chest.117.5_suppl_1.260S · DOI
  8. Kasahara, 2000, Inhibition of VEGF receptors causes lung cell apoptosis and emphysema, J Clin Invest, 106, 1311, 10.1172/JCI10259 · DOI
  9. Kasahara, 2001, Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema, Am J Respir Crit Care Med, 163, 737, 10.1164/ajrccm.163.3.2002117 · DOI
  10. Majo, 2001, Lymphocyte population and apoptosis in the lungs of smokers and their relation to emphysema, Eur Respir J, 17, 946, 10.1183/09031936.01.17509460 · DOI
  11. Aoshiba, 2003, Alveolar wall apoptosis causes lung destruction and emphysematous changes, Am J Respir Cell Mol Biol, 28, 555, 10.1165/rcmb.2002-0090OC · DOI
  12. Plataki, 2006, Apoptotic mechanisms in the pathogenesis of COPD, Int J Chron Obstruct Pulmon Dis, 1, 161
  13. Morissette, 2009, Alveolar epithelial and endothelial cell apoptosis in emphysema: what we know and what we need to know, Int J Chron Obstruct Pulmon Dis, 4, 19
  14. Hughes, 2003, Historical review: the carbon monoxide diffusing capacity (DLCO) and its membrane (DM) and red cell (Theta. Vc) components, Respir Physiol Neurobiol, 138, 115, 10.1016/j.resp.2003.08.004 · DOI
  15. Cosio Piqueras, 2001, Disease of the airways in chronic obstructive pulmonary disease, Eur Respir J Suppl, 34, 41s, 10.1183/09031936.01.00234601 · DOI
  16. Hogg, 2004, Pathophysiology of airflow limitation in chronic obstructive pulmonary disease, Lancet, 364, 709, 10.1016/S0140-6736(04)16900-6 · DOI
  17. Horstman, 2004, Endothelial microparticles as markers of endothelial dysfunction, Front Biosci, 9, 1118, 10.2741/1270 · DOI
  18. Jimenez, 2003, Endothelial cells release phenotypically and quantitatively distinct microparticles in activation and apoptosis, Thromb Res, 109, 175, 10.1016/S0049-3848(03)00064-1 · DOI
  19. Chironi, 2009, Endothelial microparticles in diseases, Cell Tissue Res, 335, 143, 10.1007/s00441-008-0710-9 · DOI · Paper page
  20. Berckmans, 2001, Cell-derived microparticles circulate in healthy humans and support low grade thrombin generation, Thromb Haemost, 85, 639, 10.1055/s-0037-1615646 · DOI
  21. Combes, 1999, In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant, J Clin Invest, 104, 93, 10.1172/JCI4985 · DOI
  22. Mallat, 2000, Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes, Circulation, 101, 841, 10.1161/01.CIR.101.8.841 · DOI
  23. Boulanger, 2001, Circulating microparticles from patients with myocardial infarction cause endothelial dysfunction, Circulation, 104, 2649, 10.1161/hc4701.100516 · DOI
  24. Bernal-Mizrachi, 2003, High levels of circulating endothelial microparticles in patients with acute coronary syndromes, Am Heart J, 145, 962, 10.1016/S0002-8703(03)00103-0 · DOI
  25. Preston, 2003, Effects of severe hypertension on endothelial and platelet microparticles, Hypertension, 41, 211, 10.1161/01.HYP.0000049760.15764.2D · DOI · Paper page
  26. Brogan, 2004, Endothelial and platelet microparticles in vasculitis of the young, Arthritis Rheum, 50, 927, 10.1002/art.20199 · DOI
  27. Gonzalez-Quintero, 2004, Elevated plasma endothelial microparticles: preeclampsia versus gestational hypertension, Am J Obstet Gynecol, 191, 1418, 10.1016/j.ajog.2004.06.044 · DOI
  28. Chirinos, 2005, Elevation of endothelial microparticles, platelets, and leukocyte activation in patients with venous thromboembolism, J Am Coll Cardiol, 45, 1467, 10.1016/j.jacc.2004.12.075 · DOI
  29. Garcia, 2005, Phenotypic assessment of endothelial microparticles in patients with heart failure and after heart transplantation: switch from cell activation to apoptosis, J Heart Lung Transplant, 24, 2184, 10.1016/j.healun.2005.07.006 · DOI
  30. Amabile, 2005, Circulating endothelial microparticles are associated with vascular dysfunction in patients with end-stage renal failure, J Am Soc Nephrol, 16, 3381, 10.1681/ASN.2005050535 · DOI
  31. Werner, 2006, Nickenig G. Circulating CD31+/Annexin V+ apoptotic microparticles correlate with coronary endothelial function in patients with coronary artery disease, Arterioscler Thromb Vasc Biol, 26, 112, 10.1161/01.ATV.0000191634.13057.15 · DOI
  32. Williams, 2007, Endothelial microparticle levels are similar in acute ischemic stroke and stroke mimics due to activation and not apoptosis/necrosis, Acad Emerg Med, 14, 685, 10.1197/j.aem.2007.04.009 · DOI
  33. Amabile, 2008, Circulating endothelial microparticle levels predict hemodynamic severity of pulmonary hypertension, Am J Respir Crit Care Med, 177, 1268, 10.1164/rccm.200710-1458OC · DOI
  34. Erdbruegger, 2008, Diagnostic role of endothelial microparticles in vasculitis, Rheumatology (Oxford), 47, 1820, 10.1093/rheumatology/ken373 · DOI
  35. Bulut, 2009, CD31+/Annexin V+ microparticles in healthy offsprings of patients with coronary artery disease, Eur J Clin Invest, 39, 17, 10.1111/j.1365-2362.2008.02058.x · DOI
  36. Danilov, 2001, Lung uptake of antibodies to endothelial antigens: key determinants of vascular immunotargeting, Am J Physiol Lung Cell Mol Physiol, 280, L1335, 10.1152/ajplung.2001.280.6.L1335 · DOI
  37. Gordon, 2010, Circulating endothelial microparticles as a measure of lung destruction in smokers [abstract], Am J Respir Crit Care Med, 181, A3444
  38. Macintyre, 2005, Standardisation of the single-breath determination of carbon monoxide uptake in the lung, Eur Respir J, 26, 720, 10.1183/09031936.05.00034905 · DOI
  39. Heijdra, 2002, Cough and phlegm are important predictors of health status in smokers without COPD, Chest, 121, 1427, 10.1378/chest.121.5.1427 · DOI
  40. Diaz, 2000, Increased susceptibility to pulmonary emphysema among HIV-seropositive smokers, Ann Intern Med, 132, 369, 10.7326/0003-4819-132-5-200003070-00006 · DOI
  41. Piccin, 2007, Circulating microparticles: pathophysiology and clinical implications, Blood Rev, 21, 157, 10.1016/j.blre.2006.09.001 · DOI
  42. George, 2008, Microparticles in vascular diseases, Thromb Res, 122, S55, 10.1016/S0049-3848(08)70020-3 · DOI
  43. Jimenez, 2001, Elevated endothelial microparticles in thrombotic thrombocytopenic purpura: findings from brain and renal microvascular cell culture and patients with active disease, Br J Haematol, 112, 81, 10.1046/j.1365-2141.2001.02516.x · DOI
  44. Minagar, 2001, Elevated plasma endothelial microparticles in multiple sclerosis, Neurology, 56, 1319, 10.1212/WNL.56.10.1319 · DOI
  45. Shet, 2003, Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes, Blood, 102, 2678, 10.1182/blood-2003-03-0693 · DOI
  46. Ferreira, 2004, Postprandial hypertriglyceridemia increases circulating levels of endothelial cell microparticles, Circulation, 110, 3599, 10.1161/01.CIR.0000148820.55611.6B · DOI
  47. Koga, 2005, Elevated levels of VE-cadherin-positive endothelial microparticles in patients with type 2 diabetes mellitus and coronary artery disease, J Am Coll Cardiol, 45, 1622, 10.1016/j.jacc.2005.02.047 · DOI
  48. Arteaga, 2006, Endothelial microparticles and platelet and leukocyte activation in patients with the metabolic syndrome, Am J Cardiol, 98, 70, 10.1016/j.amjcard.2006.01.054 · DOI
  49. Esposito, 2006, Endothelial microparticles correlate with endothelial dysfunction in obese women, J Clin Endocrinol Metab, 91, 3676, 10.1210/jc.2006-0851 · DOI
  50. Pirro, 2006, Increased ratio of CD31+/CD42- microparticles to endothelial progenitors as a aovel marker of atherosclerosis in hypercholesterolemia, Arterioscler Thromb Vasc Biol, 26, 2530, 10.1161/01.ATV.0000243941.72375.15 · DOI
  51. Sheremata, 2006, Interferon-beta1a reduces plasma CD31+ endothelial microparticles (CD31+EMP) in multiple sclerosis, J Neuroinflammation, 3, 23, 10.1186/1742-2094-3-23 · DOI
  52. Simak, 2006, Circulating endothelial microparticles in acute ischemic stroke: a link to severity, lesion volume and outcome, J Thromb Haemost, 4, 1296, 10.1111/j.1538-7836.2006.01911.x · DOI
  53. Esposito, 2007, Endothelial microparticles correlate with erectile dysfunction in diabetic men, Int J Impot Res, 19, 161, 10.1038/sj.ijir.3901500 · DOI
  54. Tushuizen, 2007, Elevated endothelial microparticles following consecutive meals are associated with vascular endothelial dysfunction in type 2 diabetes, Diabetes Care, 30, 728, 10.2337/dc06-1473 · DOI
  55. Wang, 2007, Increased circulating CD31+/CD42 microparticles are associated with impaired systemic artery elasticity in healthy subjects, Am J Hypertens, 20, 957, 10.1016/j.amjhyper.2007.04.005 · DOI
  56. Amabile, 2009, Yeghiazarians Y. Increased CD62e(+) endothelial microparticle levels predict poor outcome in pulmonary hypertension patients, J Heart Lung Transplant, 28, 1081, 10.1016/j.healun.2009.06.005 · DOI
  57. Ayers, 2009, Circulating cell-derived microparticles in patients with minimally symptomatic obstructive sleep apnoea, Eur Respir J, 33, 574, 10.1183/09031936.00107408 · DOI
  58. Harrison, 2009, The endothelial microparticle response to a high fat meal is not attenuated by prior exercise, Eur J Appl Physiol, 106, 555, 10.1007/s00421-009-1050-5 · DOI
  59. Jourde-Chiche, 2009, Levels of circulating endothelial progenitor cells are related to uremic toxins and vascular injury in hemodialysis patients, J Thromb Haemost, 7, 1576, 10.1111/j.1538-7836.2009.03540.x · DOI
  60. Michaud, 2006, Cigarette smoke exposure impairs VEGF-induced endothelial cell migration: role of NO and reactive oxygen species, J Mol Cell Cardiol, 41, 275, 10.1016/j.yjmcc.2006.05.004 · DOI
  61. Yang, 2008, Dysfunction of pulmonary vascular endothelium in chronic obstructive pulmonary disease: basic considerations for future drug development, Curr Drug Metab, 9, 661, 10.2174/138920008785821684 · DOI
  62. Edmiston, 2009, Cigarette smoke extract induced protein phosphorylation changes in human microvascular endothelial cells in vitro, Anal Bioanal Chem, 394, 1609, 10.1007/s00216-009-2856-z · DOI
  63. Heiss, 2008, Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production, J Am Coll Cardiol, 51, 1760, 10.1016/j.jacc.2008.01.040 · DOI
  64. Segura-Valdez, 2000, Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD, Chest, 117, 684, 10.1378/chest.117.3.684 · DOI
  65. Fletcher, 1977, The natural history of chronic airflow obstruction, BMJ, 1, 1645, 10.1136/bmj.1.6077.1645 · DOI
  66. Lundback, 2003, Not 15 but 50% of smokers develop COPD? Report from the Obstructive Lung Disease in Northern Sweden Studies, Respir Med, 97, 115, 10.1053/rmed.2003.1446 · DOI
  67. Bednarek, 2008, Prevalence, severity and underdiagnosis of COPD in the primary care setting, Thorax, 63, 402, 10.1136/thx.2007.085456 · DOI
  68. Rennard, 2008, Natural histories of chronic obstructive pulmonary disease, Proc Am Thorac Soc, 5, 878, 10.1513/pats.200804-035QC · DOI
  69. Coxson, 1999, A quantification of the lung surface area in emphysema using computed tomography, Am J Respir Crit Care Med, 159, 851, 10.1164/ajrccm.159.3.9805067 · DOI
  70. Newell, 2004, Report of a workshop: quantitative computed tomography scanning in longitudinal studies of emphysema, Eur Respir J, 23, 769, 10.1183/09031936.04.00026504 · DOI
  71. Madani, 2006, Pulmonary emphysema: objective quantification at multi-detector row CT-comparison with macroscopic and microscopic morphometry, Radiology, 238, 1036, 10.1148/radiol.2382042196 · DOI
  72. van Beek, 2008, Functional imaging: CT and MRI, Clin Chest Med, 29, 195, 10.1016/j.ccm.2007.12.003 · DOI
  73. Bastarrika, 2009, Low-dose volumetric computed tomography for quantification of emphysema in asymptomatic smokers participating in an early lung cancer detection trial, J Thorac Imaging, 24, 206, 10.1097/RTI.0b013e3181a65263 · DOI
  74. Cavigli, 2009, Whole-lung densitometry versus visual assessment of emphysema, Eur Radiol, 19, 1686, 10.1007/s00330-009-1320-y · DOI
  75. Lynch, 2009, Quantitative imaging of COPD, J Thorac Imaging, 24, 189, 10.1097/RTI.0b013e3181b31cf0 · DOI
  76. Tylen, 2000, Emphysematous lesions and lung function in healthy smokers 60 years of age, Respir Med, 94, 38, 10.1053/rmed.1999.0690 · DOI
  77. Spaggiari, 2005, Early smoking-induced lung lesions in asymptomatic subjects. correlations between high resolution dynamic ct and pulmonary function testing, Radiol Med (Torino), 109, 27
  78. Wilson, 2008, Association of radiographic emphysema and airflow obstruction with lung cancer, Am J Respir Crit Care Med, 178, 738, 10.1164/rccm.200803-435OC · DOI
  79. Kuwano, 1990, The diagnosis of mild emphysema. correlation of computed tomography and pathology scores, Am Rev Respir Dis, 141, 169, 10.1164/ajrccm/141.1.169 · DOI
  80. Remy-Jardin, 1996, Sliding thin slab, minimum intensity projection technique in the diagnosis of emphysema: histopathologic-CT correlation, Radiology, 200, 665, 10.1148/radiology.200.3.8756912 · DOI
  81. Gevenois, 1996, Comparison of computed density and microscopic morphometry in pulmonary emphysema, Am J Respir Crit Care Med, 154, 187, 10.1164/ajrccm.154.1.8680679 · DOI
  82. Mathews, 2008, New 133Xe gas trapping index for quantifying severe emphysema before partial lung volume reduction, J Nucl Med, 49, 771, 10.2967/jnumed.107.048637 · DOI
  83. Litmanovich, 2009, CT of pulmonary emphysema–current status, challenges, and future directions, Eur Radiol, 19, 537, 10.1007/s00330-008-1186-4 · DOI
  84. Madani, 2010, Pulmonary emphysema: effect of lung volume on objective quantification at thin-section CT, Radiology, 257, 260, 10.1148/radiol.10091446 · DOI
  85. Suga, 2010, Lung ventilation-perfusion imbalance in pulmonary emphysema: assessment with automated V/Q quotient SPECT, Ann Nucl Med, 24, 269, 10.1007/s12149-010-0369-7 · DOI
  86. Fain, 2006, Early emphysematous changes in asymptomatic smokers: detection with 3He MR imaging, Radiology, 239, 875, 10.1148/radiol.2393050111 · DOI
  87. Harvey, 2010, Natural history of asymptomatic smokers with normal spirometry and reduced diffusion capacity: do they develop COPD?, Am J Respir Crit Care Med, 181, A1531

Cited by

Metadata

Authors
Gordon, C., Gudi, K., Krause, A., Sackrowitz, R., Harvey, B.-G., Strulovici-Barel, Y., Mezey, J. G., & Crystal, R. G.
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
2011-07
Volume
184
Issue
2
Pages
224-232
ISSN
  • 1073-449X
  • 1535-4970
DOI
10.1164/rccm.201012-2061oc
Cited by
194
References
3
Language
en
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.