The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Inflammasome-regulated Cytokines Are Critical Mediators of Acute Lung Injury
Open accessAbstract
RATIONALE: Despite advances in clinical management, there are currently no reliable diagnostic and therapeutic targets for acute respiratory distress syndrome (ARDS). The inflammasome/caspase-1 pathway regulates the maturation and secretion of proinflammatory cytokines (e.g., IL-18). IL-18 is associated with injury in animal models of systemic inflammation. OBJECTIVES: We sought to determine the contribution of the inflammasome pathway in experimental acute lung injury and human ARDS. METHODS: We performed comprehensive gene expression profiling on peripheral blood from patients with critical illness. Gene expression changes were assessed using real-time polymerase chain reaction, and IL-18 levels were measured in the plasma of the critically ill patients. Wild-type mice or mice genetically deficient in IL-18 or caspase-1 were mechanically ventilated using moderate tidal volume (12 ml/kg). Lung injury parameters were assessed in lung tissue, serum, and bronchoalveolar lavage fluid. MEASUREMENTS AND MAIN RESULTS: In mice, mechanical ventilation enhanced IL-18 levels in the lung, serum, and bronchoalveolar lavage fluid. IL-18-neutralizing antibody treatment, or genetic deletion of IL-18 or caspase-1, reduced lung injury in response to mechanical ventilation. In human patients with ARDS, inflammasome-related mRNA transcripts (CASP1, IL1B, and IL18) were increased in peripheral blood. In samples from four clinical centers, IL-18 was elevated in the plasma of patients with ARDS (sepsis or trauma-induced ARDS) and served as a novel biomarker of intensive care unit morbidity and mortality. CONCLUSIONS: The inflammasome pathway and its downstream cytokines play critical roles in ARDS development.
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A role for mitochondria in nlrp3 inflammasome activation
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Gout-associated uric acid crystals activate the NALP3 inflammasome
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Cryopyrin activates the inflammasome in response to toxins and ATP
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Self-citationThioredoxin-interacting protein links oxidative stress to inflammasome activation
Zhou, R., Tardivel, A., Thorens, B., Choi, I., & Tschopp, J. (2010) · Nature Immunology · doi:10.1038/ni.1831 · Cited by 2,708
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
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Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases
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Cited by
The acute respiratory distress syndrome
Matthay, M. A., Ware, L. B., & Zimmerman, G. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60331 · Cited by 1,706
Self-citationAcute Lung Injury: A Clinical and Molecular Review
Butt, Y., Kurdowska, A., & Allen, T. C. (2016) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2015-0519-ra · Cited by 894
Nakahira, K., Kyung, S.-Y., Rogers, A. J., Gazourian, L., Youn, S., Massaro, A. F., Quintana, C., Osorio, J. C., Wang, Z., Zhao, Y., et al. (2013) · PLoS Medicine · doi:10.1371/journal.pmed.1001577 · Cited by 445
Self-citationNatural product derived phytochemicals in managing acute lung injury by multiple mechanisms
He, Y.-Q., Zhou, C.-C., Yu, L.-Y., Wang, L., Deng, J.-L., Tao, Y.-L., Zhang, F., & Chen, W.-S. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2020.105224 · Cited by 412
Savin, I. A., Zenkova, M. A., & Sen’kova, A. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314959 · Cited by 279
Metadata
- Authors
- Dolinay, T., Kim, Y. S., Howrylak, J., Hunninghake, G. M., An, C. H., Fredenburgh, L., Massaro, A. F., Rogers, A., Gazourian, L., Nakahira, K., Haspel, J. A., Landazury, R., Eppanapally, S., Christie, J. D., Meyer, N. J., Ware, L. B., Christiani, D. C., Ryter, S. W., Baron, R. M., & Choi, A. M. K.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-06-01
- Volume
- 185
- Issue
- 11
- Pages
- 1225-1234
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2155433658
- Cited by
- 563
- References
- 10
- FWCI
- 23.72
- Type
- journal article
- Language
- en
- Open access
- green
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- Dolinay, T., Kim, Y. S., Howrylak, J., Hunninghake, G. M., An, C. H., Fredenburgh, L., Massaro, A. F., Rogers, A., Gazourian, L., Nakahira, K., Haspel, J. A., Landazury, R., Eppanapally, S., Christie, J. D., Meyer, N. J., Ware, L. B., Christiani, D. C., Ryter, S. W., Baron, R. M., & Choi, A. M. K. (2012). Inflammasome-regulated Cytokines Are Critical Mediators of Acute Lung Injury. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.201201-0003oc
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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