The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Severe Sepsis in Pre-Hospital Emergency Care: Analysis of Incidence, Care, and Outcome
Open accessAbstract
RATIONALE: Severe sepsis is common and highly morbid, yet the epidemiology of severe sepsis at the frontier of the health care system-pre-hospital emergency care-is unknown. OBJECTIVES: We examined the epidemiology of pre-hospital severe sepsis among emergency medical services (EMS) encounters, relative to acute myocardial infarction and stroke. METHODS: Retrospective study using a community-based cohort of all nonarrest, nontrauma King County EMS encounters from 2000 to 2009 who were transported to a hospital. MEASUREMENTS AND MAIN RESULTS: Overall incidence rate of hospitalization with severe sepsis among EMS encounters, as well as pre-hospital characteristics, admission diagnosis, and outcomes. Among 407,176 EMS encounters, we identified 13,249 hospitalizations for severe sepsis, of whom 2,596 died in the hospital (19.6%). The crude incidence rate of severe sepsis was 3.3 per 100 EMS encounters, greater than for acute myocardial infarction or stroke (2.3 per 100 and 2.2 per 100 EMS encounters, respectively). More than 40% of all severe sepsis hospitalizations arrived at the emergency department after EMS transport, and 80% of cases were diagnosed on admission. Pre-hospital care intervals, on average, exceeded 45 minutes for those hospitalized with severe sepsis. One-half or fewer of patients with severe sepsis were transported by paramedics (n = 7,114; 54%) or received pre-hospital intravenous access (n = 4,842; 37%). CONCLUSIONS: EMS personnel care for a substantial and increasing number of patients with severe sepsis, and spend considerable time on scene and during transport. Given the emphasis on rapid diagnosis and intervention for sepsis, the pre-hospital interval may represent an important opportunity for recognition and care of sepsis.
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Cites
Early goal-directed therapy in the treatment of severe sepsis and septic shock
Rivers, E., Nguyen, B., Havstad, S., Ressler, J., Muzzin, A., Knoblich, B., Peterson, E., & Tomlanovich, M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010307 · Cited by 10,743
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock
Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J. E., Sprung, C. L., Douglas, I. S., Jaeschke, R., et al. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31827e83af · Cited by 9,694
Self-citationKumar, A., Roberts, D., Wood, K. E., Light, B., Parrillo, J. E., Sharma, S., Suppes, R., Feinstein, D., Zanotti, S., Taiberg, L., et al. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000217961.75225.e9 · Cited by 6,109
Long-term cognitive impairment and functional disability among survivors of severe sepsis.
Iwashyna, T. J., Ely, E. W., Smith, D. M., & Langa, K. M. (2010) · JAMA · doi:10.1001/jama.2010.1553 · Cited by 2,582
Gaieski, D. F., Mikkelsen, M. E., Band, R. A., Pines, J. M., Massone, R., Furia, F. F., Shofer, F. S., & Goyal, M. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181cc4824 · Cited by 970
Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007
Lagu, T., Rothberg, M. B., Shieh, M.-S., Pekow, P. S., Steingrub, J. S., & Lindenauer, P. K. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e318232db65 · Cited by 679
Iwashyna, T. J., Odden, A., Rohde, J., Bonham, C., Kuhn, L., Malani, P., Chen, L., & Flanders, S. (2014) · Medical Care · doi:10.1097/mlr.0b013e318268ac86 · Cited by 358
The national EMS research agenda executive summary
Sayre, M. R., White, L. J., Brown, L. H., & McHenry, S. D. (2002) · Annals of Emergency Medicine · doi:10.1067/mem.2002.129241 · Cited by 33
Cited by
Seymour, C. W., Liu, V. X., Iwashyna, T. J., Brunkhorst, F. M., Rea, T. D., Scherag, A., Rubenfeld, G., Kahn, J. M., Shankar-Hari, M., Singer, M., et al. (2016) · JAMA · doi:10.1001/jama.2016.0288 · Cited by 3,939
Self-citationFleischmann, C., Scherag, A., Adhikari, N. K. J., Hartog, C. S., Tsaganos, T., Schlattmann, P., Angus, D. C., & Reinhart, K. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201504-0781oc · Cited by 3,548
Self-citationMayr, F. B., Yende, S., & Angus, D. C. (2014) · Virulence · doi:10.4161/viru.27372 · Cited by 1,208
Self-citationThe timing of early antibiotics and hospital mortality in sepsis.
Liu, V. X., Fielding-Singh, V., Greene, J. D., Baker, J. M., Iwashyna, T. J., Bhattacharya, J., & Escobar, G. J. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201609-1848oc · Cited by 1,006
The Epidemiology of Chronic Critical Illness in the United States*
Kahn, J. M., Le, T., Angus, D. C., Cox, C. E., Hough, C. L., White, D. B., Yende, S., & Carson, S. S. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000000710 · Cited by 420
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Metadata
- Authors
- Seymour, C. W., Rea, T. D., Kahn, J. M., Walkey, A. J., Yealy, D. M., & Angus, D. C.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-12-15
- Volume
- 186
- Issue
- 12
- Pages
- 1264-1271
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2070115405
- Cited by
- 230
- References
- 8
- FWCI
- 10.56
- Type
- journal article
- Language
- en
- Open access
- green
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