Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007
Abstract
Objectives To assess trends in number of hospitalizations, outcomes, and costs of severe sepsis in the United States. Design Temporal trends study using the Nationwide Inpatient Sample. Patients Adult patients with severe sepsis (defined as a diagnosis of sepsis and organ dysfunction) diagnosed between 2003 and 2007. Measurements and main results We determined the weighted frequency of patients hospitalized with severe sepsis. We calculated age- and sex-adjusted population-based mortality rates for severe sepsis per 100,000 population and also used logistic regression to adjust in-hospital mortality rates for patient characteristics. We calculated inflation-adjusted costs using hospital-specific cost-to-charge ratios. We identified a rapid steady increase in the number of cases of severe sepsis, from 415,280 in 2003 to 711,736 in 2007 (a 71% increase). The total hospital costs for all patients with severe sepsis increased from $15.4 billion in 2003 to $24.3 billion in 2007 (57% increase). The proportion of patients with severe sepsis and only a single organ dysfunction decreased from 51% in 2003 to 45% in 2007 (p Conclusions The increase in the number of hospitalizations for severe sepsis coupled with declining in-hospital mortality and declining geometric mean cost per case may reflect improvements in care or increases in discharges to skilled nursing facilities; however, these findings more likely represent changes in documentation and hospital coding practices that could b…
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95% of sepsis in patients is caused by bacterial infections.
“Clinical epidemiological investigation shows that 95% of sepsis in patients is caused by bacterial infections, and early antibacterial therapy is important for increasing the survival of patients with sepsis.37,38”
From Identification of heptapeptides targeting a lethal bacterial strain in septic mice through an integrative approach (2022) · cites this paper as [38]
Early antibacterial therapy is important for increasing the survival of patients with sepsis.
“Clinical epidemiological investigation shows that 95% of sepsis in patients is caused by bacterial infections, and early antibacterial therapy is important for increasing the survival of patients with sepsis.37,38”
From Identification of heptapeptides targeting a lethal bacterial strain in septic mice through an integrative approach (2022) · cites this paper as [38]
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- Authors
- Lagu, T., Rothberg, M. B., Shieh, M.-S., Pekow, P. S., Steingrub, J. S., & Lindenauer, P. K.
- Affiliations
- Tufts University (US)
- ORCID
- Venue
- Critical Care Medicine
- Published
- 2012-03
- Volume
- 40
- Issue
- 3
- Pages
- 754-761
- ISSN
- 0090-3493 (ISSN-L)
- OpenAlex
- W2019952254
- Cited by
- 679
- References
- 0
- Citations by year
- 2026: 7 · 2025: 24 · 2024: 21 · 2023: 22 · 2022: 34 · 2021: 52 · 2020: 60 · 2019: 48 · 2018: 65 · 2017: 66 · 2016: 81 · 2015: 79 · 2014: 60 · 2013: 42 · 2012: 15
- FWCI
- 28.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Agency for Healthcare Research and Quality
- Topics
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Abdominal Surgery and Complications
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Keywords
- severe sepsis, hospitalization trends, hospital costs, in-hospital mortality, length of hospital stay, organ dysfunction, sepsis surveillance, skilled nursing facilities, cost per case, National Inpatient Sample, temporal trends, healthcare quality improvement
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Costs and Cost Analysis, Female, Hospitalization, Humans, Male, Middle Aged, Time Factors, United States, Treatment Outcome, Sepsis, Young Adult
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