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Lung Microbiota and Bacterial Abundance in Patients with Bronchiectasis when Clinically Stable and during Exacerbation
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RATIONALE: Characterization of bacterial populations in infectious respiratory diseases will provide improved understanding of the relationship between the lung microbiota, disease pathogenesis, and treatment outcomes. OBJECTIVES: To comprehensively define lung microbiota composition during stable disease and exacerbation in patients with bronchiectasis. METHODS: Sputum was collected from patients when clinically stable and before and after completion of antibiotic treatment of exacerbations. Bacterial abundance and community composition were analyzed using anaerobic culture and 16S rDNA pyrosequencing. MEASUREMENTS AND MAIN RESULTS: In clinically stable patients, aerobic and anaerobic bacteria were detected in 40 of 40 (100%) and 33 of 40 (83%) sputum samples, respectively. The dominant organisms cultured were Pseudomonas aeruginosa (n = 10 patients), Haemophilus influenzae (n = 12), Prevotella (n = 18), and Veillonella (n = 13). Pyrosequencing generated more than 150,000 sequences, representing 113 distinct microbial taxa; the majority of observed community richness resulted from taxa present in low abundance with similar patterns of phyla distribution in clinically stable patients and patients at the onset of exacerbation. After treatment of exacerbation, there was no change in total (P = 0.925), aerobic (P = 0.917), or anaerobic (P = 0.683) load and only a limited shift in community composition. Agreement for detection of bacteria by culture and pyrosequencing was good for aerobic bacteria such as P. aeruginosa (κ = 0.84) but poorer for other genera including anaerobes. Lack of agreement was largely due to bacteria being detected by pyrosequencing but not by culture. CONCLUSIONS: A complex microbiota is present in the lungs of patients with bronchiectasis and remains stable through treatment of exacerbations, suggesting that changes in microbiota composition do not account for exacerbations.
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“With remarkable consistency, all studies report no increase in bacterial burden and no decrease in community diversity during exacerbations.”
From The microbiome and critical illness (2016) · cites this paper as [139]
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Cites
Global Initiative for Chronic Obstructive Lung Disease
Gerald, L. B., & Bailey, W. C. (2002) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-200207000-00004 · Cited by 5,806
The Nature of Small-Airway Obstruction in Chronic Obstructive Pulmonary Disease
Hogg, J. C., Chu, F. S. F., Utokaparch, S., Woods, R. R., Elliott, W. M., Buzatu, L., Cherniack, R. M., Rogers, R. M., Sciurba, F. C., Coxson, H. O., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032158 · Cited by 3,828
Disordered Microbial Communities in Asthmatic Airways
Hilty, M., Burke, C. M., Pedro, H., Cárdenas, P., Bush, A., Bossley, C. J., Davies, J. C., Ervine, A., Poulter, L. W., Pachter, L. S., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008578 · Cited by 1,874
Fuchs, H. J., Borowitz, D., Christiansen, D. H., Morris, E. M., Nash, M. L., Ramsey, B. W., Rosenstein, B. J., Smith, A. L., & Wohl, M. E. B. (1994) · New England Journal of Medicine · doi:10.1056/nejm199409083311003 · Cited by 1,532
Intermittent Administration of Inhaled Tobramycin in Patients with Cystic Fibrosis
Ramsey, B. W., PEPE, M. S., Quan, J. M., Otto, K., Montgomery, A. B., Williams‐Warren, J., Vasiljev-K, M., Borowitz, D., Bowman, C. M., Marshall, B. C., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901073400104 · Cited by 1,296
Infection in the Pathogenesis and Course of Chronic Obstructive Pulmonary Disease
Sethi, S., & Murphy, T. F. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0800353 · Cited by 1,238
Topographical Continuity of Bacterial Populations in the Healthy Human Respiratory Tract
Charlson, E. S., Bittinger, K., Haas, A. R., Fitzgerald, A. S., Frank, I., Yadav, A., Bushman, F. D., & Collman, R. G. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201104-0655oc · Cited by 1,144
British Thoracic Society guideline for non-CFbronchiectasis
Pasteur, M. C., Bilton, D., Hill, A. T., & on behalf of the British Thoracic Society Bronchiectasis (non-CF) Guideline Group (2010) · Thorax · doi:10.1136/thx.2010.136119 · Cited by 1,043
Analysis of the lung microbiome in the “healthy” smoker and in COPD.
Erb-Downward, J. R., Thompson, D. L., Han, M. K., Freeman, C. M., McCloskey, L., Schmidt, L. A., Young, V. B., Toews, G. B., Curtis, J. L., Sundaram, B., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016384 · Cited by 973 · cited 6×
“For example, genomic differences have been shown to be associated with the ability of H. influenzae strains to cause exacerbations of COPD (51).”
BackgroundResultInfluentialMechanisms of Action and Clinical Application of Macrolides as Immunomodulatory Medications
Kanoh, S., & Rubin, B. K. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00078-09 · Cited by 722
An Investigation into Causative Factors in Patients with Bronchiectasis
Pasteur, M. C., Helliwell, S. M., HOUGHTON, S. J., WEBB, S. C., Foweraker, J. E., Coulden, R. A., Flower, C. D. R., Bilton, D., & Keogan, M. T. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.4.9906120 · Cited by 681
Wong, C., Jayaram, L., Karalus, N., Eaton, T., Tong, C., Hockey, H., Milne, D., Fergusson, W., Tuffery, C., Sexton, P., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60953-2 · Cited by 600
Decade-long bacterial community dynamics in cystic fibrosis airways
Zhao, J., Schloss, P. D., Kalikin, L. M., Carmody, L. A., Foster, B. K., Petrosino, J. F., Cavalcoli, J. D., VanDevanter, D. R., Murray, S., Li, J. Z., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120577109 · Cited by 599
The Lung Tissue Microbiome in Chronic Obstructive Pulmonary Disease
Sze, M. A., Dimitriu, P. A., Hayashi, S., Elliott, W. M., McDonough, J. E., Gosselink, J. V., Cooper, J. D., Sin, D. D., Mohn, W. W., & Hogg, J. C. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201111-2075oc · Cited by 569
Dowd, S. E., Wolcott, R. D., Sun, Y., McKeehan, T., Smith, E., & Rhoads, D. D. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003326 · Cited by 562
Barker, A. F. (2002) · New England Journal of Medicine · doi:10.1056/nejmra012519 · Cited by 556
Martínez‐García, M. Á., Soler‐Cataluña, J. J., Perpiñá-Tordera, M., Román-Sánchez, P., & Soriano, J. B. (2007) · CHEST Journal · doi:10.1378/chest.07-0490 · Cited by 484
Detection of Anaerobic Bacteria in High Numbers in Sputum from Patients with Cystic Fibrosis
Tunney, M. M., Field, T. R., Moriarty, T. F., Patrick, S., Doering, G., Muhlebach, M. S., Wolfgang, M. C., Boucher, R. C., Gilpin, D. F., McDowell, A., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200708-1151oc · Cited by 466
Self-citationAirway Microbiota and Pathogen Abundance in Age-Stratified Cystic Fibrosis Patients
Cox, M. J., Allgaier, M., Taylor, B., Baek, M. S., Huang, Y. J., Daly, R. A., Karaöz, U., Andersen, G. L., Brown, R., Fujimura, K. E., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011044 · Cited by 458
Chalmers, J. D., Smith, M. P., McHugh, B. J., Doherty, C., Govan, J. R. W., & Hill, A. T. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201203-0487oc · Cited by 408
Harris, J. K., Groote, M. A. D., Sagel, S. D., Zemanick, E. T., Kapsner, R. K., Penvari, C., Kaess, H., Deterding, R. R., Accurso, F. J., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709804104 · Cited by 373
Fodor, A. A., Klem, E., Gilpin, D. F., Elborn, J. S., Boucher, R. C., Tunney, M. M., & Wolfgang, M. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045001 · Cited by 362
Self-citationMadan, J. C., Koestler, D. C., Stanton, B. A., Davidson, L. E., Moulton, L. A., Housman, M. L., Moore, J. H., Guill, M. F., Morrison, H. G., Sogin, M. L., et al. (2012) · mBio · doi:10.1128/mbio.00251-12 · Cited by 361
Inhaled Aztreonam Lysine for Chronic Airway Pseudomonas aeruginosa in Cystic Fibrosis
McCoy, K., Quittner, A. L., Oermann, C. M., Gibson, R. L., Retsch‐Bogart, G. Z., & Montgomery, A. B. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200712-1804oc · Cited by 355
Tobramycin Solution for Inhalation Reduces Sputum Pseudomonas aeruginosa Density in Bronchiectasis
Barker, A. F., Couch, L., Fiel, S. B., Gotfried, M. H., Ilowite, J. S., Meyer, K. C., O’Donnell, A. E., Sahn, S. A., SMITH, L. J., STEWART, J. O., et al. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.2.9910086 · Cited by 336
Bacterial colonisation in patients with bronchiectasis: microbiological pattern and risk factors
ANGRILL, J. (2002) · Thorax · doi:10.1136/thorax.57.1.15 · Cited by 329
Sibley, C. D., Parkins, M. D., Rabin, H. R., Duan, K., Nørgaard, J. C., & Surette, M. G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804326105 · Cited by 311
British Thoracic Society guideline for non-CF bronchiectasis
Pasteur, M. C., Bilton, D., Hill, A. T., & on behalf of the British Thoracic Society Non-CF Bronchiectasis Guideline Group (2010) · Thorax · doi:10.1136/thx.2010.142778 · Cited by 288
Clinical, Pathophysiologic, and Microbiologic Characterization of Bronchiectasis in an Aging Cohort
Nicotra, M. B., Rivera, M., Dale, A. M., Shepherd, R., & Carter, R. (1995) · CHEST Journal · doi:10.1378/chest.108.4.955 · Cited by 284
Pseudomonas aeruginosa in Chronic Obstructive Pulmonary Disease
Murphy, T. F., Brauer, A. L., Eschberger, K., Lobbins, P., Grove, L., Cai, X., & Sethi, S. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200709-1413oc · Cited by 279
Partitioning core and satellite taxa from within cystic fibrosis lung bacterial communities
Gast, C., Walker, A. W., Stressmann, F. A., Rogers, G. B., Scott, P., Daniels, T. W. V., Carroll, M. P., Parkhill, J., & Bruce, K. D. (2010) · The ISME Journal · doi:10.1038/ismej.2010.175 · Cited by 265
Goddard, A. F., Staudinger, B. J., Dowd, S. E., Joshi-Datar, A., Wolcott, R. D., Aitken, M. L., Fligner, C. L., & Singh, P. K. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107435109 · Cited by 259
Trends and Burden of Bronchiectasis-Associated Hospitalizations in the United States, 1993-2006
Seitz, A. E., Olivier, K. N., Steiner, C., de Oca, R. M., Holland, S. M., & Prevots, D. R. (2010) · CHEST Journal · doi:10.1378/chest.10-0099 · Cited by 238
Significance of the microbiome in obstructive lung disease
Han, M. K., Huang, Y. J., LiPuma, J. J., Boushey, H. A., Boucher, R. C., Cookson, W., Curtis, J. L., Erb‐Downward, J. R., Lynch, S. V., Sethi, S., et al. (2012) · Thorax · doi:10.1136/thoraxjnl-2011-201183 · Cited by 235
Self-citationDrobnic, M. E., Suñé, P., Ronsano, J. B. M., Marcellés, A. F., & Orriols, R. (2004) · Annals of Pharmacotherapy · doi:10.1345/aph.1e099 · Cited by 219
Microbiologic follow-up study in adult bronchiectasis
King, P. T., Holdsworth, S. R., Freezer, N., Villanueva, E., & Holmes, P. W. (2007) · Respiratory Medicine · doi:10.1016/j.rmed.2007.03.009 · Cited by 216
Effect of sputum bacteriology on the quality of life of patients with bronchiectasis
Wilson, C., Jones, P., O’Leary, C., Hansell, D., COLE, P. J., & Wilson, R. (1997) · European Respiratory Journal · doi:10.1183/09031936.97.10081754 · Cited by 211
Effect of Estrogen on Pseudomonas Mucoidy and Exacerbations in Cystic Fibrosis
Chotirmall, S. H., Smith, S. G. J., Gunaratnam, C., Cosgrove, S., Dimitrov, B. D., O'Neill, S. J., Harvey, B. J., Greene, C. M., & McElvaney, N. G. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1106126 · Cited by 209
Quality-of-Life Determinants in Patients With Clinically Stable Bronchiectasis
Martínez‐García, M. Á., Perpiñá-Tordera, M., Román-Sánchez, P., & Soler‐Cataluña, J. J. (2005) · CHEST Journal · doi:10.1378/chest.128.2.739 · Cited by 208
Phylogenetic and metabolic diversity of bacteria associated with cystic fibrosis
Guss, A. M., Roeselers, G., Newton, I. L. G., Young, C. R., Klepac‐Ceraj, V., Lory, S., & Cavanaugh, C. M. (2010) · The ISME Journal · doi:10.1038/ismej.2010.88 · Cited by 200
Airway Bacterial Concentrations and Exacerbations of Chronic Obstructive Pulmonary Disease
Sethi, S., Sethi, R., Eschberger, K., Lobbins, P., Cai, X., Grant, B. J. B., & Murphy, T. F. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200703-417oc · Cited by 199
Non-CF bronchiectasis: does knowing the aetiology lead to changes in management?
Li, A. M., Sonnappa, S., Lex, C., Wong, E. L., Zacharasiewicz, A. S., Bush, A., & Jaffé, A. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00127704 · Cited by 198
Culture Enriched Molecular Profiling of the Cystic Fibrosis Airway Microbiome
Sibley, C. D., Grinwis, M. E., Field, T. R., Eshaghurshan, C. S., Faria, M. M. P., Dowd, S. E., Parkins, M. D., Rabin, H. R., & Surette, M. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022702 · Cited by 196
The need to redefine non-cystic fibrosis bronchiectasis in childhood
Eastham, K. M. (2004) · Thorax · doi:10.1136/thx.2003.011577 · Cited by 193
Filkins, L., Hampton, T. H., Gifford, A. H., Gross, M. J., Hogan, D. A., Sogin, M. L., Morrison, H. G., Paster, B. J., & O’Toole, G. A. (2012) · Journal of Bacteriology · doi:10.1128/jb.00566-12 · Cited by 182
Inflammatory Profile of New Bacterial Strain Exacerbations of Chronic Obstructive Pulmonary Disease
Sethi, S., Wrona, C. T., Eschberger, K., Lobbins, P., Cai, X., & Murphy, T. F. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200708-1234oc · Cited by 177
Tunney, M. M., Klem, E., Fodor, A. A., Gilpin, D. F., Moriarty, T. F., McGrath, S., Muhlebach, M. S., Boucher, R. C., Cardwell, C. R., Doering, G., et al. (2011) · Thorax · doi:10.1136/thx.2010.137281 · Cited by 176
Self-citationStressmann, F. A., Rogers, G. B., Gast, C., Marsh, P., Vermeer, L. S., Carroll, M. P., Hoffman, L. R., Daniels, T. W. V., Patel, N., Forbes, B., et al. (2012) · Thorax · doi:10.1136/thoraxjnl-2011-200932 · Cited by 153
Rogers, G. B., Carroll, M. P., Serisier, D. J., Hockey, P., Jones, G., Kehagia, V., Connett, G. J., & Bruce, K. D. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.02282-05 · Cited by 150
Does bacterial density in cystic fibrosis sputum increase prior to pulmonary exacerbation?
Stressmann, F. A., Rogers, G. B., Marsh, P., Lilley, A. K., Daniels, T. W. V., Carroll, M. P., Hoffman, L. R., Jones, G., Allen, C. E., Patel, N., et al. (2011) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2011.05.002 · Cited by 130
Antibiotic-resistant obligate anaerobes during exacerbations of cystic fibrosis patients
Worlitzsch, D., Rintelen, C., Böhm, K., Wollschläger, B., Merkel, N., Borneff-Lipp, M., & Döring, G. (2009) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2008.02659.x · Cited by 121
Blainey, P. C., Milla, C. E., Cornfield, D. N., & Quake, S. R. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004458 · Cited by 120
Hare, K. M., Grimwood, K., Leach, A. J., Smith‐Vaughan, H., Torzillo, P. J., Morris, P. S., & Chang, A. B. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.06.002 · Cited by 112
Effects of long-term low-dose azithromycin in patients with non-CF bronchiectasis
Anwar, G. A., Bourke, S. C., Afolabi, G., Middleton, P. G., Ward, C., & Rutherford, R. (2008) · Respiratory Medicine · doi:10.1016/j.rmed.2008.06.005 · Cited by 95
Zemanick, E. T., Wagner, B. D., Sagel, S. D., Stevens, M. J., Accurso, F. J., & Harris, J. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015101 · Cited by 87
Zhao, J., Carmody, L. A., Kalikin, L. M., Li, J. Z., Petrosino, J. F., Schloss, P. D., Young, V. B., & LiPuma, J. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033127 · Cited by 69
Fabbri, L. M., Boschetto, P., & Mapp, C. E. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200706-854ed · Cited by 63
Rogers, G. B., Daniels, T. W. V., Tuck, A. C., Carroll, M. P., Connett, G. J., David, G. J. P., & Bruce, K. D. (2009) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-9-14 · Cited by 63
Socioeconomic deprivation, readmissions, mortality and acute exacerbations of bronchiectasis
Roberts, M. E., Lowndes, L., Milne, D. G., & Wong, C. (2011) · Internal Medicine Journal · doi:10.1111/j.1445-5994.2011.02444.x · Cited by 63
Long-term antibiotics in the management of non-CF bronchiectasis—do they improve outcome?
Evans, D. J., & Greenstone, M. A. (2003) · Respiratory Medicine · doi:10.1016/s0954-6111(03)00063-5 · Cited by 45
Fernaays, M. M., Lesse, A. J., Sethi, S., Cai, X., & Murphy, T. F. (2006) · Infection and Immunity · doi:10.1128/iai.01904-05 · Cited by 45
British Thoracic Society national bronchiectasis audit 2010 and 2011: Figure 1
Hill, A. T., Welham, S. A., Reid, K., Bucknall, C. E., & On behalf of the British Thoracic Society (2012) · Thorax · doi:10.1136/thoraxjnl-2012-201983 · Cited by 42
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Metadata
- Authors
- Tunney, M. M., Einarsson, G. G., Wei, L., Drain, M., Klem, E. R., Cardwell, C., Ennis, M., Boucher, R. C., Wolfgang, M. C., & Elborn, J. S.
- Affiliations
- Cystic Fibrosis and Airways Microbiology Research Group
- Centre for Infection and Immunity, School of Medicine, Dentistry, and Biomedical Sciences, Queen’s University Belfast, Belfast, United Kingdom
- University of North Carolina at Chapel Hill (US)
- Queen's University Belfast (GB)
- Corresponding author
- Tunney, Michael M.
- ORCID
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-05
- Volume
- 187
- Issue
- 10
- Pages
- 1118-1126
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- PMC
- PMC3734618
- OpenAlex
- W2116345416
- Cited by
- 316
- References
- 62
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 25 · 2023: 21 · 2022: 20 · 2021: 22 · 2020: 18 · 2019: 24 · 2018: 37 · 2017: 35 · 2016: 31 · 2015: 26 · 2014: 31 · 2013: 6
- FWCI
- 25.52
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- Funders
- Public Health Agency (STL/3713/07, CDV/3650/07)
- National Heart, Lung, and Blood Institute (R01HL092964, HL092964)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- bronchiectasis, lung microbiome, bacterial abundance, exacerbations, sputum microbiome, Pseudomonas aeruginosa, Haemophilus influenzae, Prevotella, Veillonella, anaerobic bacteria, bacterial community composition, antibiotic therapy
- MeSH terms
- Aged, Anti-Bacterial Agents, Bronchiectasis, Cross-Sectional Studies, Female, Humans, Longitudinal Studies, Lung, Male, Sputum, Cohort Studies, Metagenome
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