The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Evolution of Mortality over Time in Patients Receiving Mechanical Ventilation
Abstract
RATIONALE: Baseline characteristics and management have changed over time in patients requiring mechanical ventilation; however, the impact of these changes on patient outcomes is unclear. OBJECTIVES: To estimate whether mortality in mechanically ventilated patients has changed over time. METHODS: Prospective cohort studies conducted in 1998, 2004, and 2010, including patients receiving mechanical ventilation for more than 12 hours in a 1-month period, from 927 units in 40 countries. To examine effects over time on mortality in intensive care units, we performed generalized estimating equation models. MEASUREMENTS AND MAIN RESULTS: We included 18,302 patients. The reasons for initiating mechanical ventilation varied significantly among cohorts. Ventilatory management changed over time (P < 0.001), with increased use of noninvasive positive-pressure ventilation (5% in 1998 to 14% in 2010), a decrease in tidal volume (mean 8.8 ml/kg actual body weight [SD = 2.1] in 1998 to 6.9 ml/kg [SD = 1.9] in 2010), and an increase in applied positive end-expiratory pressure (mean 4.2 cm H2O [SD = 3.8] in 1998 to 7.0 cm of H2O [SD = 3.0] in 2010). Crude mortality in the intensive care unit decreased in 2010 compared with 1998 (28 versus 31%; odds ratio, 0.87; 95% confidence interval, 0.80-0.94), despite a similar complication rate. Hospital mortality decreased similarly. After adjusting for baseline and management variables, this difference remained significant (odds ratio, 0.78; 95% confidence interval, 0.67-0.92). CONCLUSIONS: Patient characteristics and ventilation practices have changed over time, and outcomes of mechanically ventilated patients have improved. Clinical trials registered with www.clinicaltrials.gov (NCT01093482).
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(2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421801 · Cited by 12,941
An Intervention to Decrease Catheter-Related Bloodstream Infections in the ICU
Pronovost, P., Needham, D., Berenholtz, S., Sinopoli, D., Chu, H., Cosgrove, S., Sexton, B., Hyzy, R., Welsh, R., Roth, G., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061115 · Cited by 4,387
Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome.
Amato, M. B. P., Barbas, C. S. V., Medeiros, D. M., Magaldi, R. B., Schettino, G. P., Lorenzi-Filho, G., Kairalla, R. A., Deheinzelin, D., Munoz, C., Oliveira, R., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802053380602 · Cited by 3,654
Serpa Neto, A., Cardoso, S. O., Manetta, J. A., Pereira, V. G. M., Espósito, D. C., Pasqualucci, M. D. O. P., Damasceno, M. C. T., & Schultz, M. J. (2012) · JAMA · doi:10.1001/jama.2012.13730 · Cited by 843
BROCHARD, L., ROUDOT-THORAVAL, F., ROUPIE, E., DELCLAUX, C., CHASTRE, J., FERNANDEZ-MONDÉJAR, E., CLÉMENTI, E., MANCEBO, J., FACTOR, P., MATAMIS, D., et al. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.6.9801044 · Cited by 800
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Frat, J.-P., Thille, A. W., Mercat, A., Girault, C., Ragot, S., Perbet, S., Prat, G., Boulain, T., Morawiec, E., Cottereau, A., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1503326 · Cited by 2,342
Self-citationEvolution of Diaphragm Thickness during Mechanical Ventilation. Impact of Inspiratory Effort
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Self-citationDemoule, A., Chevret, S., Carlucci, A., Kouatchet, A., Jaber, S., Meziani, F., Schmidt, M., Schnell, D., Clergue, C., Aboab, J., et al. (2016) · Intensive Care Medicine · doi:10.1007/s00134-015-4087-4 · Cited by 194
Self-citationGoligher, E. C., Kavanagh, B. P., Rubenfeld, G. D., Adhikari, N. K. J., Pinto, R., Fan, E., Brochard, L. J., Granton, J. T., Mercat, A., Marie Richard, J.-C., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201404-0688oc · Cited by 194
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Metadata
- Authors
- Esteban, A., Frutos-Vivar, F., Muriel, A., Ferguson, N. D., Peñuelas, O., Abraira, V., Raymondos, K., Rios, F., Nin, N., Apezteguía, C., Violi, D. A., Thille, A. W., Brochard, L., González, M., Villagomez, A. J., Hurtado, J., Davies, A. R., Du, B., Maggiore, S. M., Pelosi, P., Soto, L., Tomicic, V., D’Empaire, G., Matamis, D., Abroug, F., Moreno, R. P., Soares, M. A., Arabi, Y., Sandi, F., Jibaja, M., Amin, P., Koh, Y., Kuiper, M. A., Bülow, H.-H., Zeggwagh, A. A., & Anzueto, A.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-07-15
- Volume
- 188
- Issue
- 2
- Pages
- 220-230
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2031865625
- Cited by
- 676
- References
- 5
- FWCI
- 43.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Esteban, A., Frutos-Vivar, F., Muriel, A., Ferguson, N. D., Peñuelas, O., Abraira, V., Raymondos, K., Rios, F., Nin, N., Apezteguía, C., Violi, D. A., Thille, A. W., Brochard, L., González, M., Villagomez, A. J., Hurtado, J., Davies, A. R., Du, B., Maggiore, S. M., . . . Anzueto, A. (2013). Evolution of Mortality over Time in Patients Receiving Mechanical Ventilation. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.201212-2169oc
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