The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Pulmonary Hypertension in Heart Failure. Epidemiology, Right Ventricular Function, and Survival
Open accessAbstract
RATIONALE: Patients with pulmonary hypertension due to left heart disease (PH-LHD) and a diastolic pulmonary vascular pressure gradient ≥ 7 mm Hg, representing PH out of proportion to pulmonary arterial wedge pressure, have pulmonary vascular disease and increased mortality. Little information exists on this condition, recently labeled as "combined pre- and post-capillary PH" (Cpc-PH). OBJECTIVES: To investigate epidemiology, risk factors, right ventricular function, and outcomes in patients with chronic heart failure and Cpc-PH. METHODS: The study population was identified from a retrospective chart review of a clinical database of 3,107 stable patients who underwent first diagnostic right heart catheterization and from a prospective cohort of 800 consecutive patients at a national university-affiliated tertiary center. MEASUREMENTS AND MAIN RESULTS: The retrospective cohort had 664 patients with systolic heart failure (SHF) and 399 patients with diastolic heart failure (DHF), 12% of whom were classified as Cpc-PH. The prospective cohort had 172 patients with SHF (14% Cpc-PH) and 219 patients with DHF (12% Cpc-PH). Chronic obstructive pulmonary disease (P = 0.034) and the tricuspid annular plane systolic excursion to systolic pulmonary artery pressure ratio (P = 0.015) predicted Cpc-PH in SHF. Younger age (P = 0.004), valvular heart disease (P = 0.046), and the tricuspid annular plane systolic excursion to systolic pulmonary artery pressure ratio predicted Cpc-PH in DHF (P = 0.016). Right ventricular-pulmonary vascular coupling was worse in Cpc-PH patients (end-systolic elastance to effective arterial elastance [Ees/Ea]: SHF: 1.05 ± 0.25; P = 0.002; DHF: 1.17 ± 0.27; P = 0.027) than in those with isolated post-capillary PH (Ees/Ea: SHF: 1.52 ± 0.51; DHF: 1.45 ± 0.29). CONCLUSIONS: Cpc-PH is rare in chronic heart failure. Right ventricular-pulmonary vascular coupling is poor in Cpc-PH and could be one explanation for dismal outcomes.
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Cites
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Self-citationUnderlying Causes and Long-Term Survival in Patients with Initially Unexplained Cardiomyopathy
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Cited by
Tello, K., Wan, J., Dalmer, A., Vanderpool, R., Ghofrani, H. A., Naeije, R., Roller, F., Mohajerani, E., Seeger, W., Herberg, U., et al. (2019) · Circulation: Cardiovascular Imaging · doi:10.1161/circimaging.119.009047 · Cited by 599
Pulmonary hypertension due to left heart disease
Vachiéry, J.-L., Tedford, R. J., Rosenkranz, S., Palazzini, M., Lang, I., Guazzi, M., Coghlan, G., Chazova, I., & De Marco, T. (2019) · European Respiratory Journal · doi:10.1183/13993003.01897-2018 · Cited by 555
Self-citationGuazzi, M., Dixon, D., Labate, V., Beussink-Nelson, L., Bandera, F., Cuttica, M. J., & Shah, S. J. (2017) · JACC: Cardiovascular Imaging · doi:10.1016/j.jcmg.2016.12.024 · Cited by 444
Gorter, T. M., van Veldhuisen, D. J., Bauersachs, J., Borlaug, B. A., Celutkiene, J., Coats, A. J. S., Crespo-Leiro, M. G., Guazzi, M., Harjola, V.-P., Heymans, S., et al. (2018) · European Journal of Heart Failure · doi:10.1002/ejhf.1029 · Cited by 389
The Giessen Pulmonary Hypertension Registry: Survival in pulmonary hypertension subgroups
Gall, H., Felix, J. F., Schneck, F. K., Milger, K., Sommer, N., Voswinckel, R., Franco, O. H., Hofman, A., Schermuly, R. T., Weissmann, N., et al. (2017) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2017.02.016 · Cited by 313
Metadata
- Authors
- Gerges, M., Gerges, C., Pistritto, A.-M., Lang, M. B., Trip, P., Jakowitsch, J., Binder, T., & Lang, I. M.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-11-15
- Volume
- 192
- Issue
- 10
- Pages
- 1234-1246
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W1690550543
- Cited by
- 265
- References
- 34
- FWCI
- 20.46
- Type
- journal article
- Language
- en
- Open access
- green
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- Gerges, M., Gerges, C., Pistritto, A.-M., Lang, M. B., Trip, P., Jakowitsch, J., Binder, T., & Lang, I. M. (2015). Pulmonary Hypertension in Heart Failure. Epidemiology, Right Ventricular Function, and Survival. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.201503-0529oc
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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