TOLLIP , MUC5B , and the Response to N -Acetylcysteine among Individuals with Idiopathic Pulmonary Fibrosis

Oldham, Justin M.; Ma, Shwu-Fan; Martinez, Fernando J.; Anstrom, Kevin J.; Raghu, Ganesh; Schwartz, David A.; Valenzi, Eleanor; Witt, Leah; Lee, Cathryn; Vij, Rekha; Huang, Yong; Strek, Mary E.; Noth, Imre

doi:10.1164/rccm.201505-1010oc

TOLLIP , MUC5B , and the Response to N -Acetylcysteine among Individuals with Idiopathic Pulmonary Fibrosis

Rationale Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease of unknown etiology. The genes TOLLIP and MUC5B play important roles in lung host defense, which is an immune process influenced by oxidative signaling. Whether polymorphisms in TOLLIP and MUC5B modify the effect of immun…