Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 435

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations

Open access
Denlinger, Loren C., Phillips, Brenda R., Ramratnam, Sima, Ross, Kristie, Bhakta, Nirav R., Cardet, Juan Carlos, Castro, Mario, Peters, Stephen P., Phipatanakul, Wanda, Aujla, Shean, Bacharier, Leonard B., Bleecker, Eugene R., Comhair, Suzy A. A., Coverstone, Andrea, DeBoer, Mark, Erzurum, Serpil C., Fain, Sean B., Fajt, Merritt, Fitzpatrick, Anne M., Gaffin, Jonathan, Gaston, Benjamin, Hastie, Annette T., Hawkins, Gregory A., Holguin, Fernando, Irani, Anne-Marie, Israel, Elliot, Levy, Bruce D., Ly, Ngoc, Meyers, Deborah A., Moore, Wendy C., Myers, Ross, Opina, Maria Theresa D., Peters, Michael C., Schiebler, Mark L., Sorkness, Ronald L., Teague, W. Gerald, Wenzel, Sally E., Woodruff, Prescott G., Mauger, David T., Fahy, John V., Jarjour, Nizar N.·2017·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/rccm.201602-0419oc
Open this paper in CoChat — free account

Abstract

RATIONALE: Reducing asthma exacerbation frequency is an important criterion for approval of asthma therapies, but the clinical features of exacerbation-prone asthma (EPA) remain incompletely defined. OBJECTIVES: To describe the clinical, physiologic, inflammatory, and comorbidity factors associated with EPA. METHODS: Baseline data from the NHLBI Severe Asthma Research Program (SARP)-3 were analyzed. An exacerbation was defined as a burst of systemic corticosteroids lasting 3 days or more. Patients were classified by their number of exacerbations in the past year: none, few (one to two), or exacerbation prone (≥3). Replication of a multivariable model was performed with data from the SARP-1 + 2 cohort. MEASUREMENTS AND MAIN RESULTS: Of 709 subjects in the SARP-3 cohort, 294 (41%) had no exacerbations and 173 (24%) were exacerbation prone in the prior year. Several factors normally associated with severity (asthma duration, age, sex, race, and socioeconomic status) did not associate with exacerbation frequency in SARP-3; bronchodilator responsiveness also discriminated exacerbation proneness from asthma severity. In the SARP-3 multivariable model, blood eosinophils, body mass index, and bronchodilator responsiveness were positively associated with exacerbation frequency (rate ratios [95% confidence interval], 1.6 [1.2-2.1] for every log unit of eosinophils, 1.3 [1.1-1.4] for every 10 body mass index units, and 1.2 [1.1-1.4] for every 10% increase in bronchodilatory responsiveness). Chronic sinusitis and gastroesophageal reflux were also associated with exacerbation frequency (1.7 [1.4-2.1] and 1.6 [1.3-2.0]), even after adjustment for multiple factors. These effects were replicated in the SARP-1 + 2 multivariable model. CONCLUSIONS: EPA may be a distinct susceptibility phenotype with implications for the targeting of exacerbation prevention strategies. Clinical trial registered with www.clinicaltrials.gov (NCT 01760915).

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1164/rccm.201602-0419oc

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 32 references

Cited by

See all 435

Metadata

Authors
Denlinger, L. C., Phillips, B. R., Ramratnam, S., Ross, K., Bhakta, N. R., Cardet, J. C., Castro, M., Peters, S. P., Phipatanakul, W., Aujla, S., Bacharier, L. B., Bleecker, E. R., Comhair, S. A. A., Coverstone, A., DeBoer, M., Erzurum, S. C., Fain, S. B., Fajt, M., Fitzpatrick, A. M., Gaffin, J., Gaston, B., Hastie, A. T., Hawkins, G. A., Holguin, F., Irani, A.-M., Israel, E., Levy, B. D., Ly, N., Meyers, D. A., Moore, W. C., Myers, R., Opina, M. T. D., Peters, M. C., Schiebler, M. L., Sorkness, R. L., Teague, W. G., Wenzel, S. E., Woodruff, P. G., Mauger, D. T., Fahy, J. V., & Jarjour, N. N.
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
2017-02-01
Volume
195
Issue
3
Pages
302-313
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
DOI
10.1164/rccm.201602-0419oc
OpenAlex
W2517035143
Cited by
435
References
32
FWCI
32.63
Type
journal article
Language
en
Open access
green

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations. https://app.cochat.ai/papers/10.1164/rccm.201602-0419oc
The paper
Denlinger, L. C., Phillips, B. R., Ramratnam, S., Ross, K., Bhakta, N. R., Cardet, J. C., Castro, M., Peters, S. P., Phipatanakul, W., Aujla, S., Bacharier, L. B., Bleecker, E. R., Comhair, S. A. A., Coverstone, A., DeBoer, M., Erzurum, S. C., Fain, S. B., Fajt, M., Fitzpatrick, A. M., . . . Jarjour, N. N. (2017). Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.201602-0419oc

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.