Severe asthma in children
Abstract
Severe asthma in children is associated with significant morbidity and is a highly heterogeneous disorder with multiple clinical phenotypes. Cluster analyses have been performed in several groups to explain some of the heterogeneity of pediatric severe asthma, which is reviewed in this article. The evaluation of a child with severe asthma includes a detailed diagnostic assessment and excluding other possible diagnoses and addressing poor control due to comorbidities, lack of adherence to asthma controller medications, poor technique, and other psychological and environmental factors. Children with severe asthma require significant resources including regular follow-up appointments with asthma education, written asthma action plan, and care by a multidisciplinary team. Management of pediatric severe asthma now includes emerging phenotypic-directed therapies; however, continued research is still needed to further study the long-term outcomes of pediatric severe asthma and its treatment.
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Severe asthma in children is much more variable with rapidly evolving severe attacks, often remaining symptom-free between attacks.
“Severe asthma is predominantly persistent in adults, but much more variable with rapidly evolving severe attacks in children, often remaining symptom-free between the attacks (75, 76).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [76]
Severe asthma is predominantly persistent in adults.
“Severe asthma is predominantly persistent in adults, but much more variable with rapidly evolving severe attacks in children, often remaining symptom-free between the attacks (75, 76).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [76]
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Epidemiology of Asthma in Children and Adults
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Do not forget asthma comorbidities in pediatric severe asthma!
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Socioeconomic status, diet, and recurrent severe asthma exacerbations in Puerto Rican youth
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Song, D., Jiang, Y., Zhao, Q., Li, J., & Zhao, Y. (2022) · Computational and Mathematical Methods in Medicine · doi:10.1155/2022/7499911 · Cited by 6 · see citing works
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Biologic Therapies for Severe Asthma in School-Age Children
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Astım Hastalarında Tedavinin Nitrik Oksit ve Asimetrik Dimetil Arginin Düzeylerine Etkisi
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- Authors
- Ramratnam, S. K., Bacharier, L. B., & Guilbert, T. W.
- Affiliations
- University of Wisconsin–Madison (US)
- St. Louis Children's Hospital (US)
- Cincinnati Children's Hospital Medical Center (US)
- Corresponding author
- Ramratnam, Sima K.
- Venue
- The Journal of Allergy and Clinical Immunology In Practice
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 5
- Issue
- 4
- Pages
- 889-898
- ISSN
- 2213-2198 (ISSN-L)
- OpenAlex
- W4211114960
- Cited by
- 119
- References
- 109
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 14 · 2023: 11 · 2022: 16 · 2021: 14 · 2020: 21 · 2019: 14 · 2018: 14 · 2017: 2
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Allergy and Clinical Immunology In Practice (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Keywords
- severe asthma, childhood asthma, asthma phenotypes, asthma heterogeneity, clustering, asthma control, comorbidities, medication adherence, asthma action plan, asthma education, multidisciplinary care
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