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Cited by 282

The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.

At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease

Open access
Martinez, Fernando J., Han, MeiLan K., Allinson, James P., Barr, R. Graham, Boucher, Richard C., Calverley, Peter M. A., Celli, Bartolome R., Christenson, Stephanie A., Crystal, Ronald G., Fagerås, Malin, Freeman, Christine M., Groenke, Lars, Hoffman, Eric A., Kesimer, Mehmet, Kostikas, Kostantinos, Paine, Robert, Rafii, Shahin, Rennard, Stephen I., Segal, Leopoldo N., Shaykhiev, Renat, Stevenson, Christopher, Tal-Singer, Ruth, Vestbo, Jørgen, Woodruff, Prescott G., Curtis, Jeffrey L., Wedzicha, Jadwiga A.·2018·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/rccm.201710-2028pp
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Abstract

Chronic obstructive pulmonary disease (COPD) is a prevalent, heterogeneous disorder with varying presentation and progression but with a limited number of disease-modifying therapies (1). This marked heterogeneity impedes identification of subpopulations at risk for accelerated progression, thwarting therapeutic advances. Most COPD studies have included populations with mean ages older than 60 years (2). However, it is increasingly evident that lung function trajectories in COPD differ significantly and that differences are detectable in young adulthood (3–5). In this Perspective, we highlight the need to distinguish “early disease” from late “mild disease,” propose an operational definition of early COPD for use in research studies, and attempt to unify current views on potential disease mechanisms. We focus on smoking, the chief etiologic factor for COPD in the industrialized world. Whether pathogenic mechanisms and effective treatments are shared with the sizable fraction of COPD in never-smokers or resulting from biomass fuel, electronic nicotine delivery systems, and other exposures, are separate, significant questions. We argue that refocusing investigation on early COPD could revolutionize understanding and therapies of this leading cause of worldwide death.

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Metadata

Authors
Martinez, F. J., Han, M. K., Allinson, J. P., Barr, R. G., Boucher, R. C., Calverley, P. M. A., Celli, B. R., Christenson, S. A., Crystal, R. G., Fagerås, M., Freeman, C. M., Groenke, L., Hoffman, E. A., Kesimer, M., Kostikas, K., Paine, R., Rafii, S., Rennard, S. I., Segal, L. N., Shaykhiev, R., Stevenson, C., Tal-Singer, R., Vestbo, J., Woodruff, P. G., Curtis, J. L., & Wedzicha, J. A.
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
2018-06-15
Volume
197
Issue
12
Pages
1540-1551
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
DOI
10.1164/rccm.201710-2028pp
OpenAlex
W2785817999
Cited by
282
References
125
FWCI
18.26
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease. https://app.cochat.ai/papers/10.1164/rccm.201710-2028pp
The paper
Martinez, F. J., Han, M. K., Allinson, J. P., Barr, R. G., Boucher, R. C., Calverley, P. M. A., Celli, B. R., Christenson, S. A., Crystal, R. G., Fagerås, M., Freeman, C. M., Groenke, L., Hoffman, E. A., Kesimer, M., Kostikas, K., Paine, R., Rafii, S., Rennard, S. I., Segal, L. N., . . . Wedzicha, J. A. (2018). At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.201710-2028pp

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.