Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease
Open accessAbstract
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is thought to result from an accelerated decline in forced expiratory volume in 1 second (FEV1) over time. Yet it is possible that a normal decline in FEV1 could also lead to COPD in persons whose maximally attained FEV1 is less than population norms. METHODS: We stratified participants in three independent cohorts (the Framingham Offspring Cohort, the Copenhagen City Heart Study, and the Lovelace Smokers Cohort) according to lung function (FEV1 ≥80% or <80% of the predicted value) at cohort inception (mean age of patients, approximately 40 years) and the presence or absence of COPD at the last study visit. We then determined the rate of decline in FEV1 over time among the participants according to their FEV1 at cohort inception and COPD status at study end. RESULTS: Among 657 persons who had an FEV1 of less than 80% of the predicted value before 40 years of age, 174 (26%) had COPD after 22 years of observation, whereas among 2207 persons who had a baseline FEV1 of at least 80% of the predicted value before 40 years of age, 158 (7%) had COPD after 22 years of observation (P<0.001). Approximately half the 332 persons with COPD at the end of the observation period had had a normal FEV1 before 40 years of age and had a rapid decline in FEV1 thereafter, with a mean (±SD) decline of 53±21 ml per year. The remaining half had had a low FEV1 in early adulthood and a subsequent mean decline in FEV1 of 27±18 ml per year (P<0.001), despite similar smoking exposure. CONCLUSIONS: Our study suggests that low FEV1 in early adulthood is important in the genesis of COPD and that accelerated decline in FEV1 is not an obligate feature of COPD. (Funded by an unrestricted grant from GlaxoSmithKline and others.).
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A longitudinal, population-based, cohort study of childhood asthma followed to adulthood
Sears, M. R., Greene, J. M., Willan, A. R., Wiecek, E. M., Taylor, D. R., Flannery, E. M., Cowan, J. O., Herbison, G. P., Silva, P. A., & Poulton, R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022363 · Cited by 1,460 · see citing works
Early lung development: lifelong effect on respiratory health and disease
Stocks, J., Hislop, A., & Sonnappa, S. (2013) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70118-8 · Cited by 390 · see citing works
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Pavord, I. D., Beasley, R., Agusti, A., Anderson, G. P., Bel, E., Brusselle, G., Cullinan, P., Custovic, A., Ducharme, F. M., Fahy, J. V., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(17)30879-6 · Cited by 1,073 · see citing works
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McGeachie, M. J., Yates, K. P., Zhou, X., Guo, F., Sternberg, A. L., Van Natta, M. L., Wise, R. A., Szefler, S. J., Sharma, S., Kho, A. T., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1513737 · Cited by 608 · see citing works
Bui, D. S., Lodge, C. J., Burgess, J. A., Lowe, A. J., Perret, J., Bui, M. Q., Bowatte, G., Gurrin, L., Johns, D. P., Thompson, B. R., et al. (2018) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(18)30100-0 · Cited by 602 · see citing works
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Khan, S. S., Singer, B. D., & Vaughan, D. E. (2017) · Aging Cell · doi:10.1111/acel.12601 · Cited by 530 · see citing works
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England, L. J., Aagaard, K., Bloch, M., Conway, K., Cosgrove, K., Grana, R., Gould, T. J., Hatsukami, D., Jensen, F., Kandel, D., et al. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.013 · Cited by 181 · see citing works
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Periodontal status and lung function decline in the community: the Hisayama study.
Takeuchi, K., Matsumoto, K., Furuta, M., Fukuyama, S., Takeshita, T., Ogata, H., Suma, S., Shibata, Y., Shimazaki, Y., Hata, J., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-31610-3 · Cited by 20 · see citing works
- Authors
- Lange, P., Celli, B., Agustí, A., Boje Jensen, G., Divo, M., Faner, R., Guerra, S., Marott, J. L., Martinez, F. D., Martinez-Camblor, P., Meek, P., Owen, C. A., Petersen, H., Pinto-Plata, V., Schnohr, P., Sood, A., Soriano, J. B., Tesfaigzi, Y., & Vestbo, J.
- Affiliations
- University of Copenhagen (DK)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
- Brigham and Women's Hospital (US)
- University of Arizona (US)
- Frederiksberg Hospital (DK)
- University of Colorado Denver (US)
- Lovelace Respiratory Research Institute (US)
- University of New Mexico (US)
- Universidad Autónoma de Madrid (ES)
- Manchester Academic Health Science Centre (GB)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2015-07-09
- Volume
- 373
- Issue
- 2
- Pages
- 111-122
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W770714277
- Cited by
- 1,284
- References
- 2
- Citations by year
- 2026: 71 · 2025: 102 · 2024: 144 · 2023: 132 · 2022: 129 · 2021: 140 · 2020: 120 · 2019: 114 · 2018: 129 · 2017: 104 · 2016: 77 · 2015: 22
- FWCI
- 87.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya) (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Hispana (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, public-domain)
- Biblos-e Archivo (Universidad Autónoma de Madrid) (submittedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
- Funders
- National Institutes of Health (5r01hl068111-18)
- National Heart, Lung, and Blood Institute (P50HL107165, R01-HL068111, R56HL068111, R01HL140839, K23HL094531)
- National Institute of Environmental Health Sciences (R01ES015482)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- chronic obstructive pulmonary disease, lung function decline, FEV1, smoking, COPD pathogenesis, lung function trajectories
- MeSH terms
- Adult, Aged, Female, Forced Expiratory Volume, Humans, Male, Middle Aged, Smoking, Cohort Studies, Disease Progression, Pulmonary Disease, Chronic Obstructive, Young Adult
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