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Understanding and Enhancing Sepsis Survivorship. Priorities for Research and Practice
Open accessAbstract
An estimated 14.1 million patients survive sepsis each year. Many survivors experience poor long-term outcomes, including new or worsened neuropsychological impairment; physical disability; and vulnerability to further health deterioration, including recurrent infection, cardiovascular events, and acute renal failure. However, clinical trials and guidelines have focused on shorter-term survival, so there are few data on promoting longer-term recovery. To address this unmet need, the International Sepsis Forum convened a colloquium in February 2018 titled “Understanding and Enhancing Sepsis Survivorship.” The goals were to identify gaps and limitations of current research and shorter- and longer-term priorities for understanding and enhancing sepsis survivorship. Twenty-six experts from eight countries participated. The top short-term priorities identified by nominal group technique culminating in formal voting were to better leverage existing databases for research, develop and disseminate educational resources on postsepsis morbidity, and partner with sepsis survivors to define and achieve research priorities. The top longer-term priorities were to study mechanisms of long-term morbidity through large cohort studies with deep phenotyping, build a harmonized global sepsis registry to facilitate enrollment in cohorts and trials, and complete detailed longitudinal follow-up to characterize the diversity of recovery experiences. This perspective reviews colloquium discussions, the identified priorities, and current initiatives to address them.
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“While efficacy data are equivocal, these programmes are consistently well-liked by patients and offer an environment to learn about challenges sepsis survivors face, as well as to pilot and test interventions for enhancing recovery [637, 643].”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [643]
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Metadata
- Authors
- Prescott, H. C., Iwashyna, T. J., Blackwood, B., Calandra, T., Chlan, L. L., Choong, K., Connolly, B., Dark, P., Ferrucci, L., Finfer, S., Girard, T. D., Hodgson, C., Hopkins, R. O., Hough, C. L., Jackson, J. C., Machado, F. R., Marshall, J. C., Misak, C., Needham, D. M., Panigrahi, P., Reinhart, K., Yende, S., Zafonte, R., Rowan, K. M., & Angus, D. C.
- Affiliations
- University of Michigan (US)
- Queen's University Belfast (GB)
- Centre Hospitalier Universitaire Vaudois (CH)
- Mayo Clinic (US)
- McMaster University (CA)
- National Health Service (GB)
- King's College London (GB)
- National Institutes of Health (US)
- UNSW Sydney (AU)
- University of Pittsburgh (US)
- Monash University (AU)
- Brigham Young University (US)
- University of Washington (US)
- Vanderbilt University (US)
- Anesthesiology, Pain, and Intensive Care Department, Federal University of São Paulo, São Paulo, Brazil
- St. Michael's Hospital (CA)
- University of Toronto (CA)
- Johns Hopkins University (US)
- Georgetown University Medical Center (US)
- Jena University Hospital (DE)
- Brigham and Women's Hospital (US)
- Intensive Care National Audit and Research Centre, London, United Kingdom
- Corresponding author
- Prescott, Hallie C.
- ORCID
- Prescott, Hallie C.
- Iwashyna, Theodore J.
- Blackwood, Bronagh
- Calandra, Thierry
- Chlan, Linda L.
- Choong, Karen
- Connolly, Bronwen
- Dark, Paul
- Ferrucci, Luigi
- Finfer, Simon
- Girard, Timothy D.
- Hodgson, Carol
- Hough, Catherine L.
- Jackson, James C.
- Marshall, John C.
- Needham, Dale M.
- Panigrahi, Pinaki
- Reinhart, Konrad
- Yende, Sachin
- Zafonte, Ross
- Angus, Derek C.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-10
- Volume
- 200
- Issue
- 8
- Pages
- 972-981
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- PMC
- PMC6794113
- OpenAlex
- W2948089944
- Cited by
- 166
- References
- 72
- Citations by year
- 2026: 17 · 2025: 24 · 2024: 23 · 2023: 29 · 2022: 23 · 2021: 30 · 2020: 17 · 2019: 2
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion, other-oa)
- Monash University Research Portal (Monash University) (submittedVersion, other-oa)
- IRIS (submittedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion, other-oa)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Institute for Health and Care Research (PDF-2015-08-015)
- Queen's University Belfast
- Queen's University
- National Institutes of Health
- Medical Research Council
- National Health and Medical Research Council (1117230)
- National Institute on Aging
- National Heart, Lung, and Blood Institute (R01HL135144)
- National Institute of General Medical Sciences (R01GM097471, K08GM115859)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Keywords
- long-term recovery, neuropsychological deficits, physical disability, recurrent infections, acute kidney injury, cardiovascular events, cohort studies, phenotyping
- MeSH terms
- Survivorship, Adult, Aged, Aged, 80 and over, Critical Care, Female, Persons with Disabilities, Humans, Male, Middle Aged, Research Design, Cohort Studies, Practice Guidelines as Topic, Sepsis, Biomedical Research
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