Improving Lung Function in Severe Heterogenous Emphysema with the Spiration Valve System (EMPROVE). A Multicenter, Open-Label Randomized Controlled Clinical Trial

Criner, Gerard J.; Delage, Antoine; Voelker, Kirk; Hogarth, D. Kyle; Majid, Adnan; Zgoda, Michael; Lazarus, Donald R.; Casal, Roberto; Benzaquen, Sadia B.; Holladay, Robert C.; Wellikoff, Adam; Calero, Karel; Rumbak, Mark J.; Branca, Paul R.; Abu-Hijleh, Muhanned; Mallea, Jorge M.; Kalhan, Ravi; Sachdeva, Ashutosh; Kinsey, C. Matthew; Lamb, Carla R.; Reed, Michael F.; Abouzgheib, Wissam B.; Kaplan, Phillip V.; Marrujo, Gregory X.; Johnstone, David W.; Gasparri, Mario G.; Meade, Arturo A.; Hergott, Christopher A.; Reddy, Chakravarthy; Mularski, Richard A.; Case, Amy Hajari; Makani, Samir S.; Shepherd, Ray W.; Chen, Benson; Holt, Gregory E.; Martel, Simon

doi:10.1164/rccm.201902-0383oc

Improving Lung Function in Severe Heterogenous Emphysema with the Spiration Valve System (EMPROVE). A Multicenter, Open-Label Randomized Controlled Clinical Trial

Rationale Less invasive, nonsurgical approaches are needed to treat severe emphysema. Objectives To evaluate the effectiveness and safety of the Spiration Valve System (SVS) versus optimal medical management. Methods In this multicenter, open-label, randomized, controlled trial, subjects aged 40 …