The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Endobronchial Valve Therapy in Patients with Homogeneous Emphysema. Results from the IMPACT Study
Abstract
Abstract Rationale Endobronchial valves (EBVs) have been successfully used in patients with severe heterogeneous emphysema to improve lung physiology. Limited available data suggest that EBVs are also effective in homogeneous emphysema. Objectives To evaluate the efficacy and safety of EBVs in patients with homogeneous emphysema with absence of collateral ventilation assessed with the Chartis system. Methods Prospective, multicenter, 1:1 randomized controlled trial of EBV plus standard of care (SoC) or SoC alone. Primary outcome was the percentage change in FEV1 (liters) at 3 months relative to baseline in the EBV group versus the SoC group. Secondary outcomes included changes in FEV1, St. George’s Respiratory Questionnaire (SGRQ), 6-minute-walk distance (6MWD), and target lobe volume reduction. Measurements and Main Results Ninety-three subjects (age, 63.7 ± 6.1 yr [mean ± SD]; FEV1, % predicted, 29.3 ± 6.5; residual volume, % predicted, 275.4 ± 59.4) were allocated to either the EBV group (n = 43) or the SoC group (n = 50). In the intention-to-treat population, at 3 months postprocedure, improvement in FEV1 from baseline was 13.7 ± 28.2% in the EBV group and −3.2 ± 13.0% in the SoC group (mean between-group difference, 17.0%; P = 0.0002). Other variables demonstrated statistically and clinically significant changes from baseline to 3 months (EBV vs. SoC, respectively: SGRQ, −8.63 ± 11.25 vs. 1.01 ± 9.36; and 6MWD, 22.63 ± 66.63 m vs. −17.34 ± 52.8 m). Target lobe volume reduction at 3 months was −1,195 ± 683 ml (P < 0.0001). Of the EBV subjects, 97.2% achieved volume reduction in the target lobe (P < 0.0001). Procedure-related pneumothoraces occurred in 11 subjects (25.6%). Five subjects required removal/replacement of one or more valves. One subject experienced two valve migration events requiring removal/replacement of valves. Conclusions EBV in patients with homogeneous emphysema without collateral ventilation results in clinically meaningful benefits of improved lung function, exercise tolerance, and quality of life.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema
(2003) · New England Journal of Medicine · doi:10.1056/nejmoa030287 · Cited by 2,071
Outcomes for COPD pharmacological trials: from lung function to biomarkers
Cazzola, M., MacNee, W., Martinez, F. J., Rabe, K. F., Franciosi, L. G., Barnes, P. J., Brusasco, V., Burge, P. S., Calverley, P. M. A., Celli, B. R., et al. (2008) · European Respiratory Journal · doi:10.1183/09031936.00099306 · Cited by 858
A Randomized Study of Endobronchial Valves for Advanced Emphysema
Sciurba, F. C., Ernst, A., Herth, F. J. F., Strange, C., Criner, G. J., Marquette, C. H., Kovitz, K. L., Chiacchierini, R. P., Goldin, J., & McLennan, G. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0900928 · Cited by 832
Self-citationMinimal Clinically Important Differences in COPD Lung Function
Donohue, J. F. (2005) · COPD: Journal of Chronic Obstructive Pulmonary Disease · doi:10.1081/copd-200053377 · Cited by 529
Endobronchial Valves for Emphysema without Interlobar Collateral Ventilation
Klooster, K., ten Hacken, N. H. T., Hartman, J. E., Kerstjens, H. A. M., van Rikxoort, E. M., & Slebos, D.-J. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1507807 · Cited by 487
Self-citationSciurba, F. C., Rogers, R. M., Keenan, R. J., Slivka, W. A., Gorcsan, J., Ferson, P. F., Holbert, J. M., Brown, M. L., & Landreneau, R. J. (1996) · New England Journal of Medicine · doi:10.1056/nejm199604253341704 · Cited by 462
Davey, C., Zoumot, Z., Jordan, S., McNulty, W. H., Carr, D. H., Hind, M. D., Hansell, D. M., Rubens, M. B., Banya, W., Polkey, M. I., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60001-0 · Cited by 362
Efficacy predictors of lung volume reduction with Zephyr valves in a European cohort
Herth, F. J. F., Noppen, M., Valipour, A., Leroy, S., Vergnon, J.-M., Ficker, J. H., Egan, J. J., Gasparini, S., Agusti, C., Holmes-Higgin, D., et al. (2012) · European Respiratory Journal · doi:10.1183/09031936.00161611 · Cited by 337
Self-citationRadiological and clinical outcomes of using Chartis™ to plan endobronchial valve treatment
Herth, F. J. F., Eberhardt, R., Gompelmann, D., Ficker, J. H., Wagner, M., Ek, L., Schmidt, B., & Slebos, D.-J. (2013) · European Respiratory Journal · doi:10.1183/09031936.00015312 · Cited by 274
Self-citationSciurba, F. C., Criner, G. J., Strange, C., Shah, P. L., Michaud, G., Connolly, T. A., Deslée, G., Tillis, W. P., Delage, A., Marquette, C.-H., et al. (2016) · JAMA · doi:10.1001/jama.2016.6261 · Cited by 242
Self-citation
Cited by
Criner, G. J., Sue, R., Wright, S., Dransfield, M., Rivas-Perez, H., Wiese, T., Sciurba, F. C., Shah, P. L., Wahidi, M. M., de Oliveira, H. G., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201803-0590oc · Cited by 428
Self-citationCriner, G. J., Delage, A., Voelker, K., Hogarth, D. K., Majid, A., Zgoda, M., Lazarus, D. R., Casal, R., Benzaquen, S. B., Holladay, R. C., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201902-0383oc · Cited by 182
“In addition, the EMPROVE study, and other recent multicenter, randomized controlled trials, did not blind either subjects or assessors (16, 25, 34).”
Background
Metadata
- Authors
- Valipour, A., Slebos, D.-J., Herth, F., Darwiche, K., Wagner, M., Ficker, J. H., Petermann, C., Hubner, R.-H., Stanzel, F., & Eberhardt, R.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-11-01
- Volume
- 194
- Issue
- 9
- Pages
- 1073-1082
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2507196609
- Cited by
- 365
- References
- 36
- FWCI
- 33.63
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Endobronchial Valve Therapy in Patients with Homogeneous Emphysema. Results from the IMPACT Study. https://app.cochat.ai/papers/10.1164/rccm.201607-1383oc
- The paper
- Valipour, A., Slebos, D.-J., Herth, F., Darwiche, K., Wagner, M., Ficker, J. H., Petermann, C., Hubner, R.-H., Stanzel, F., & Eberhardt, R. (2016). Endobronchial Valve Therapy in Patients with Homogeneous Emphysema. Results from the IMPACT Study. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.201607-1383oc
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
