The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Pulmonary Angiopathy in Severe COVID-19: Physiologic, Imaging, and Hematologic Observations
Open accessAbstract
Abstract Rationale Clinical and epidemiologic data in coronavirus disease (COVID-19) have accrued rapidly since the outbreak, but few address the underlying pathophysiology. Objectives To ascertain the physiologic, hematologic, and imaging basis of lung injury in severe COVID-19 pneumonia. Methods Clinical, physiologic, and laboratory data were collated. Radiologic (computed tomography (CT) pulmonary angiography [n = 39] and dual-energy CT [DECT, n = 20]) studies were evaluated: observers quantified CT patterns (including the extent of abnormal lung and the presence and extent of dilated peripheral vessels) and perfusion defects on DECT. Coagulation status was assessed using thromboelastography. Measurements and Results In 39 consecutive patients (male:female, 32:7; mean age, 53 ± 10 yr [range, 29–79 yr]; Black and minority ethnic, n = 25 [64%]), there was a significant vascular perfusion abnormality and increased physiologic dead space (dynamic compliance, 33.7 ± 14.7 ml/cm H2O; Murray lung injury score, 3.14 ± 0.53; mean ventilatory ratios, 2.6 ± 0.8) with evidence of hypercoagulability and fibrinolytic “shutdown”. The mean CT extent (±SD) of normally aerated lung, ground-glass opacification, and dense parenchymal opacification were 23.5 ± 16.7%, 36.3 ± 24.7%, and 42.7 ± 27.1%, respectively. Dilated peripheral vessels were present in 21/33 (63.6%) patients with at least two assessable lobes (including 10/21 [47.6%] with no evidence of acute pulmonary emboli). Perfusion defects on DECT (assessable in 18/20 [90%]) were present in all patients (wedge-shaped, n = 3; mottled, n = 9; mixed pattern, n = 6). Conclusions Physiologic, hematologic, and imaging data show not only the presence of a hypercoagulable phenotype in severe COVID-19 pneumonia but also markedly impaired pulmonary perfusion likely caused by pulmonary angiopathy and thrombosis.
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Pathological findings of COVID-19 associated with acute respiratory distress syndrome
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Endothelial cell infection and endotheliitis in COVID-19
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Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19
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Covid-19 in Critically Ill Patients in the Seattle Region — Case Series
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Wu, X., Liu, X., Zhou, Y., Yu, H., Li, R., Zhan, Q., Ni, F., Fang, S., Lu, Y., Ding, X., et al. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00174-0 · Cited by 696
Lanzoni, G., Linetsky, E., Correa, D., Messinger Cayetano, S., Alvarez, R. A., Kouroupis, D., Alvarez Gil, A., Poggioli, R., Ruiz, P., Marttos, A. C., et al. (2021) · Stem Cells Translational Medicine · doi:10.1002/sctm.20-0472 · Cited by 404
Tissue-Specific Immunopathology in Fatal COVID-19
Dorward, D. A., Russell, C. D., Um, I. H., Elshani, M., Armstrong, S. D., Penrice-Randal, R., Millar, T., Lerpiniere, C. E. B., Tagliavini, G., Hartley, C. S., et al. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202008-3265oc · Cited by 323
Manolis, A. S., Manolis, T. A., Manolis, A. A., Papatheou, D., & Melita, H. (2021) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248420958973 · Cited by 134
Metadata
- Authors
- Patel, B. V., Arachchillage, D. J., Ridge, C. A., Bianchi, P., Doyle, J. F., Garfield, B., Ledot, S., Morgan, C., Passariello, M., Price, S., Singh, S., Thakuria, L., Trenfield, S., Trimlett, R., Weaver, C., Wort, S. J., Xu, T., Padley, S. P. G., Devaraj, A., & Desai, S. R.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-09-01
- Volume
- 202
- Issue
- 5
- Pages
- 690-699
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W3042486011
- Cited by
- 293
- References
- 35
- FWCI
- 7.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Patel, B. V., Arachchillage, D. J., Ridge, C. A., Bianchi, P., Doyle, J. F., Garfield, B., Ledot, S., Morgan, C., Passariello, M., Price, S., Singh, S., Thakuria, L., Trenfield, S., Trimlett, R., Weaver, C., Wort, S. J., Xu, T., Padley, S. P. G., Devaraj, A., & Desai, S. R. (2020). Pulmonary Angiopathy in Severe COVID-19: Physiologic, Imaging, and Hematologic Observations. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.202004-1412oc
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