Endothelial cell infection and endotheliitis in COVID-19
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Acute embolism in small vessels may be caused by direct viral invasion via ACE-2 receptors, resulting in endothelitis and inflammation, recruiting immune cells, and expressing high levels of pro-inflammatory cytokines, such as IL-6 and TNF-alfa, with consequent apoptosis of endothelial cells.
“Acute embolism in small vessels may be caused by the direct viral invasion, via ACE-2 Receptors, resulting in endothelitis and inflammation, recruiting immune cells, and expressing high levels of pro-inflammatory cytokines, such as Il-6 and TNF-alfa, with consequently apoptosis of the endothelial cells [69].”
From Acute mesenteric ischemia in COVID-19 patients (2021) · cites this paper as [69]
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Pneumatosis Intestinalis in the Setting of COVID-19: A Single Center Case Series From New York
Miyara, S. J., Becker, L. B., Guevara, S., Kirsch, C., Metz, C. N., Shoaib, M., Grodstein, E., Nair, V. V., Jandovitz, N., McCann-Molmenti, A., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.638075 · Cited by 9 · see citing works
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Beaumont, M., Selleron, B., Passard, G., Karsandi, K., Proffit, M., Valentin, R., & Poncin, W. (2026) · Physiotherapy Canada · doi:10.3138/ptc-2024-0066
- Authors
- Varga, Z., Flammer, A. J., Steiger, P., Haberecker, M., Andermatt, R., Zinkernagel, A. S., Mehra, M. R., Schuepbach, R. A., Ruschitzka, F., & Moch, H.
- Affiliations
- University Hospital Zurich (CH)
- Brigham and Women's Hospital (US)
- Corresponding author
- Ruschitzka, Frank
- ORCID
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2020-05
- Volume
- 395
- Issue
- 10234
- Pages
- 1417-1418
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- PMC
- PMC7172722
- OpenAlex
- W3017125154
- Cited by
- 6,358
- References
- 16
- Citations by year
- 2026: 133 · 2025: 236 · 2024: 436 · 2023: 713 · 2022: 1157 · 2021: 1934 · 2020: 1732 · 2019: 2 · 2018: 4 · 2012: 4
- FWCI
- 181.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Lancet (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Brigham and Women's Hospital
- Universitätsspital Zürich
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Ophthalmology › Retinal and Optic Conditions
- Keywords
- COVID-19 pandemic, SARS-CoV-2, endothelial cell infection, endothelial inflammation, cardiovascular complications, cardiovascular comorbidity, endothelial dysfunction
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Aged, Autopsy, Female, Humans, Inflammation, Kidney, Liver, Lung, Male, Middle Aged, Myocardium, Pneumonia, Viral, Kidney Transplantation, Coronavirus Infections, Endothelial Cells, Pandemics
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