Cited by 6,358COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 ResearchRetinal and Optic Conditions

Endothelial cell infection and endotheliitis in COVID-19

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Varga, Zsuzsanna, Flammer, Andreas J, Steiger, Peter, Haberecker, Martina, Andermatt, Rea, Zinkernagel, Annelies S, Mehra, Mandeep R, Schuepbach, Reto A +2 more·2020·The Lancet

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Crossref · 10.1016/s0140-6736(20)30937-5

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  • Acute embolism in small vessels may be caused by direct viral invasion via ACE-2 receptors, resulting in endothelitis and inflammation, recruiting immune cells, and expressing high levels of pro-inflammatory cytokines, such as IL-6 and TNF-alfa, with consequent apoptosis of endothelial cells.

    “Acute embolism in small vessels may be caused by the direct viral invasion, via ACE-2 Receptors, resulting in endothelitis and inflammation, recruiting immune cells, and expressing high levels of pro-inflammatory cytokines, such as Il-6 and TNF-alfa, with consequently apoptosis of the endothelial cells [69].”

    From Acute mesenteric ischemia in COVID-19 patients (2021) · cites this paper as [69]

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Authors
Varga, Z., Flammer, A. J., Steiger, P., Haberecker, M., Andermatt, R., Zinkernagel, A. S., Mehra, M. R., Schuepbach, R. A., Ruschitzka, F., & Moch, H.
Affiliations
  • University Hospital Zurich (CH)
  • Brigham and Women's Hospital (US)
Corresponding author
Ruschitzka, Frank
Venue
The Lancet
Publisher
Elsevier BV
Published
2020-05
Volume
395
Issue
10234
Pages
1417-1418
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
OpenAlex
W3017125154
Cited by
6,358
References
16
Citations by year
2026: 133 · 2025: 236 · 2024: 436 · 2023: 713 · 2022: 1157 · 2021: 1934 · 2020: 1732 · 2019: 2 · 2018: 4 · 2012: 4
FWCI
181.64
Type
journal article
Language
en
Open access
Locations
  • The Lancet (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Brigham and Women's Hospital
  • Universitätsspital Zürich
Topics
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Health Sciences › Medicine › Ophthalmology › Retinal and Optic Conditions
Keywords
COVID-19 pandemic, SARS-CoV-2, endothelial cell infection, endothelial inflammation, cardiovascular complications, cardiovascular comorbidity, endothelial dysfunction
MeSH terms
Betacoronavirus, COVID-19, SARS-CoV-2, Aged, Autopsy, Female, Humans, Inflammation, Kidney, Liver, Lung, Male, Middle Aged, Myocardium, Pneumonia, Viral, Kidney Transplantation, Coronavirus Infections, Endothelial Cells, Pandemics

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