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Cited by 355

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Interleukin-4 is required for the induction of lung Th2 mucosal immunity.

Coyle, A J, Le Gros, G, Bertrand, C, Tsuyuki, S, Heusser, C H, Kopf, M, Anderson, G P·1995·American Journal of Respiratory Cell and Molecular Biology
DOI 10.1165/ajrcmb.13.1.7598937
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Abstract

Aerosol antigen challenge of ovalbumin-sensitized mice induced an eosinophilic airway inflammation that was dependent on interleukin (IL)-5 and CD4+, but not CD8+, T lymphocytes. The involvement of the Th2 phenotype of CD4+ T cells was supported by demonstrating that FACS-sorted purified lung T cells from sensitized, but not control, mice produced IL-4, IL-5, and IL-10 after activation of the CD3/TCR complex. To determine the role of IL-4 in this process, we used mice in which the gene for IL-4 was deleted by homologous recombination. Antigen challenge of IL-4 gene-targeted mice resulted in a marked attenuation of eosinophilic inflammation and IL-5 secretion. To more fully understand the time when IL-4 was involved, we administered a neutralizing anti-IL-4 antibody (11B11) either immediately before antigen challenge or during immunization. Inhibition of IL-4 before antigen challenge had little effect on antigen-induced eosinophil infiltration. However, when 11B11 was administered during immunization, there was a marked reduction in eosinophil infiltration. Cross-linking of the CD3/TCR complex of FACS-sorted lung T cells revealed that only when anti-IL-4 was administered during immunization was there an inhibition of T cell-derived IL-5 and IgE production. These results suggest that IL-4 is central both to the induction of a local Th2 response and to the development of eosinophilic inflammation of the lung. Moreover, we suggest a sequential involvement of IL-4 and IL-5, with IL-4 committing naive T cells to a Th2 phenotype which upon activation by aerosol provocation secrete IL-5, resulting in eosinophil accumulation.

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Metadata

Authors
Coyle, A. J., Le Gros, G., Bertrand, C., Tsuyuki, S., Heusser, C. H., Kopf, M., & Anderson, G. P.
Venue
American Journal of Respiratory Cell and Molecular Biology
Publisher
Oxford University Press (OUP)
Published
1995-07
Volume
13
Issue
1
Pages
54-59
ISSN
  • 1044-1549 (ISSN-L)
  • 1535-4989
DOI
10.1165/ajrcmb.13.1.7598937
OpenAlex
W2142006903
Cited by
355
References
11
FWCI
10.56
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Interleukin-4 is required for the induction of lung Th2 mucosal immunity. https://app.cochat.ai/papers/10.1165/ajrcmb.13.1.7598937
The paper
Coyle, A. J., Le Gros, G., Bertrand, C., Tsuyuki, S., Heusser, C. H., Kopf, M., & Anderson, G. P. (1995). Interleukin-4 is required for the induction of lung Th2 mucosal immunity. American Journal of Respiratory Cell and Molecular Biology. https://doi.org/10.1165/ajrcmb.13.1.7598937

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.