The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Combined Nasal Challenge with Diesel Exhaust Particles and Allergen Induces In Vivo IgE Isotype Switching
Abstract
In this study we undertook to provide evidence for local in vivo isotype switching to IgE following nasal challenges. Detection of deleted switch circular DNA (switch circles) by a novel nested polymerase chain reaction-based approach was employed as definitive molecular evidence of Ig isotype switching. Nasal challenge in humans with diesel exhaust particles (DEP) plus ragweed antigen has been shown to enhance local IgE production, stimulate local cytokine production, and markedly increase mucosal IgE antibody to ragweed. Four days after combined intranasal DEP plus ragweed challenge, we detected and characterized clones of deleted switch circular DNA (Sepsilon /Smu) representing switching from mu to epsilon from nasal lavage cells. No switch circular DNA was detected in nasal lavage cells following challenge with DEP alone nor with ragweed allergen alone. These results indicate that the combination of mucosal stimulation with DEP and ragweed allergen is capable of driving in vivo isotype switching to IgE in humans with ragweed allergy. These results are the first direct demonstration of in vivo IgE isotype switching in humans.
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Durham, S. R., Ying, S., Varney, V. A., Jacobson, M. R., Sudderick, R. M., Mackay, I. S., Kay, A. B., & Hamid, Q. A. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.8.2390 · Cited by 557
Upper Respiratory Tract Environmental Tobacco Smoke Sensitivity
Bascom, R., Kulle, T., Kagey-Sobotka, A., & Proud, D. (1991) · American Review of Respiratory Disease · doi:10.1164/ajrccm/143.6.1304 · Cited by 105
Cited by
Allergic Rhinitis and Its Impact on Asthma
Bousquet, J., van Cauwenberge, P., & Khaltaev, N. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.118891 · Cited by 3,588
Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis
Cheng, L., Chen, J., Fu, Q., He, S., Li, H., Liu, Z., Tan, G., Tao, Z., Wang, D., Wen, W., et al. (2018) · Allergy, Asthma & Immunology Research · doi:10.4168/aair.2018.10.4.300 · Cited by 361
Diaz-Sanchez, D., Garcia, M. P., Wang, M., Jyrala, M., & Saxon, A. (1999) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(99)70011-4 · Cited by 334
Self-citationSénéchal, H., Visez, N., Charpin, D., Shahali, Y., Peltre, G., Biolley, J.-P., Lhuissier, F., Couderc, R., Yamada, O., Malrat-Domenge, A., et al. (2015) · The Scientific World Journal · doi:10.1155/2015/940243 · Cited by 250
Allergen Drives Class Switching to IgE in the Nasal Mucosa in Allergic Rhinitis
Takhar, P., Smurthwaite, L., Coker, H. A., Fear, D. J., Banfield, G. K., Carr, V. A., Durham, S. R., & Gould, H. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.5024 · Cited by 230
Metadata
- Authors
- Fujieda, S., Diaz-Sanchez, D., & Saxon, A.
- Venue
- American Journal of Respiratory Cell and Molecular Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-09-01
- Volume
- 19
- Issue
- 3
- Pages
- 507-512
- ISSN
- 1044-1549 (ISSN-L)
- 1535-4989
- OpenAlex
- W2157351234
- Cited by
- 174
- References
- 2
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Combined Nasal Challenge with Diesel Exhaust Particles and Allergen Induces In Vivo IgE Isotype Switching. https://app.cochat.ai/papers/10.1165/ajrcmb.19.3.3143
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- Fujieda, S., Diaz-Sanchez, D., & Saxon, A. (1998). Combined Nasal Challenge with Diesel Exhaust Particles and Allergen Induces In Vivo IgE Isotype Switching. American Journal of Respiratory Cell and Molecular Biology. https://doi.org/10.1165/ajrcmb.19.3.3143
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