The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Airway Mucus Obstruction: Mucin Glycoproteins, MUC Gene Regulation and Goblet Cell Hyperplasia
Abstract
The mucus layer that coats the airway epithelium provides a protective barrier against pathogenic and noxious agents and participates in the mucosal response to inflammation and infection. Airway mucus is composed of water, ions, lung secretions, serum protein transudates, and mucin glycoproteins (mucins). Mucins are the major components of mucus and the macromolecules that impart rheologic properties to airway mucus (1, 2). Airway mucus is overproduced in the upper and/or lower respiratory tracts during acute challenges and in chronic conditions (asthma, cystic fibrosis, bronchitis, and sinusitis), thereby contributing to mucus obstruction of the airways (3). Mucus obstruction is the culmination of several complex processes including mucin ( MUC ) gene regulation, mucin secretion and goblet cell hyperplasia (GCH) (Figure 1). Insight into each of these processes is limited; more detailed information about fundamental cellular mechanisms will be required to better understand their interrelationships. For example, pathogenic agents and inflammatory mediators initiate secretion of mucins (4–7) and sustain mucin production by increasing expression of mucin genes (8, 9). Nevertheless, each process has markedly different kinetics and their response to mediators likely involves different cellular signaling and pathways. The increasing availability of molecular probes for specific mucin genes and gene products is beginning to provide some insights into the pathogenesis of mucus overproduction. However, detailed information about the expression and regulation of respiratory tract mucins in specific disease entities is still incomplete. The report by Chen and colleagues (10) provides new information on altered expression of a specific mucin gene, MUC5B.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Adherence of S. aureus and Bordetella pertussis to Hep-2 (human epidermoid cancer) epithelial cells was found in greater quantities for cells infected with RSV than for noninfected cells (240, 241)”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [241]
Citations
Cites
Interleukin-13: Central Mediator of Allergic Asthma
Wills-Karp, M. A., Luyimbazi, J., Xu, X., Schofield, B., Neben, T. Y., Karp, C. L., & Donaldson, D. D. (1998) · Science · doi:10.1126/science.282.5397.2258 · Cited by 2,611
Requirement for IL-13 Independently of IL-4 in Experimental Asthma
Grünig, G., Warnock, M. L., Wakil, A. E., Venkayya, R., Brombacher, F., Rennick, D. M., Sheppard, D., Mohrs, M., Donaldson, D. D., Locksley, R. M., et al. (1998) · Science · doi:10.1126/science.282.5397.2261 · Cited by 1,845
IMMUNOLOGIC BASIS OF ANTIGEN-INDUCED AIRWAY HYPERRESPONSIVENESS
Wills-Karp, M. A. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.255 · Cited by 1,022
Gendler, S. J., & Spicer, A. P. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.003135 · Cited by 1,001
Ordoñez, C. L., Khashayar, R., Wong, H. H., Ferrando, R., Wu, R., Hyde, D. M., Hotchkiss, J. A., ZHANG, Y., Novikov, A. A., Dolganov, G., et al. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.2.2004039 · Cited by 577
Airway goblet cells: responsive and adaptable front-line defenders
Rogers, D. (1994) · European Respiratory Journal · doi:10.1183/09031936.94.07091690 · Cited by 561
Audie, J. P., Janin, A., Porchet, N., Copin, M., Gosselin, B. H., & Aubert, J. (1993) · Journal of Histochemistry & Cytochemistry · doi:10.1177/41.10.8245407 · Cited by 458
MUC13, a Novel Human Cell Surface Mucin Expressed by Epithelial and Hemopoietic Cells
Williams, S. J., Wreschner, D. H., Tran, M. H., Eyre, H. J., Sutherland, G. R., & McGuckin, M. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008850200 · Cited by 329
Wickström, C., Davies, J. R., Eriksen, G. V., Veerman, E. C. I., & Carlstedt, I. (1998) · Biochemical Journal · doi:10.1042/bj3340685 · Cited by 315
Two novel mucin genes down-regulated in colorectal cancer identified by differential display.
Williams, S. J., McGuckin, M. A., Gotley, D. C., Eyre, H. J., Sutherland, G. R., & Antalis, T. (1999) · PubMed · Cited by 300
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–157 of 157
Tulbah, A. S., Ong, H. X., Colombo, P., Young, P. M., & Traini, D. (2016) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2016.1193150 · Cited by 15
Human airway submucosal glands augment eosinophil chemotaxis during rhinovirus infection
Furukawa, E., Ohrui, T., Yamaya, M., Suzuki, T., Nakasato, H., Sasaki, T., Kanda, A., Yasuda, H., Nishimura, H., & Sasaki, H. (2004) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2004.1865.x · Cited by 15
Phillips, J. E., Case, N. R., Celly, C. S., Chapman, R. W., Hey, J. A., & Minnicozzi, M. (2005) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2005.03.001 · Cited by 14
Guo, Y., Zhang, J., Li, X., Wu, J., Han, J., Yang, G., & Zhang, L. (2022) · British Poultry Science · doi:10.1080/00071668.2022.2122025 · Cited by 13
Popov, G., Aleksandrov, R., Petkova, V., Kaneva, R. P., Gergova, R. T., Kundurzhiev, T., & Popova, D. P. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12051808 · Cited by 13
Limvuttegrijerat, T., Poachanukoon, O., Koontongkaew, S., & Ayudhya, T. D. N. (2014) · Asian Pacific Journal of Allergy and Immunology · doi:10.12932/ap0517.32.4.2014 · Cited by 13
Gao, F.-S., Gao, Y., Liu, M., & Liu, Y.-Q. (2012) · Experimental Lung Research · doi:10.3109/01902148.2012.676705 · Cited by 12
Iwashita, J., Hongo, K., Ito, Y., Abé, T., & Murata, J. (2013) · Advances in Biological Chemistry · doi:10.4236/abc.2013.31001 · Cited by 11
PKCθ Synergizes with TLR-Dependent TRAF6 Signaling Pathway to Upregulate MUC5AC Mucin via CARMA1
Jono, H., Lim, J. H., Xu, H., & Li, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031049 · Cited by 10
Kim, Y., Choi, Y. J., Lee, E.-J., Kang, M., Park, S., Kim, D. Y., Oh, H., Park, S., & Kang, Y. (2017) · Nutrition Research and Practice · doi:10.4162/nrp.2017.11.6.461 · Cited by 10
Li, M., Tian, Y., Wu, S., Yu, H., & Li, Y. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1817-1 · Cited by 10
Influence of inhaled beclomethasone and montelukast on airway remodeling in mice
Abdelaziz, R. R., Helaly, N. Y., Zalata, K. R., & Gameil, N. M. (2012) · Inflammopharmacology · doi:10.1007/s10787-012-0127-7 · Cited by 9
A Morphologic and Immunohistochemical Study of Nasal Mucosa in Leatherworkers
Palomba, A., Iaia, T. E., Biancalani, M., Conti, S., Battista, G., Papaleo, B., & Franchi, A. (2008) · American Journal of Rhinology · doi:10.2500/ajr.2008.22.3201 · Cited by 9
Chronological expression ofCiliated Bronchial Epithelium 1during pulmonary development
Haitchi, H. M., Yoshisue, H., Ribbene, A., Wilson, S. J., Holloway, J. W., Bucchieri, F., Hanley, N. A., Wilson, D. I., Zummo, G., Holgate, S. T., et al. (2009) · European Respiratory Journal · doi:10.1183/09031936.00157108 · Cited by 9
Effect of Udenafil on MUC5B Expression in Human Airway Epithelial Cells
Park, N. K., Choi, Y. S., Lee, J. H., Kim, H.-S., Kim, J. K., Ahn, J. H., Choi, Y. H., Song, S., Bae, C. H., & Kim, Y. (2013) · Korean Journal of Otorhinolaryngology - Head and Neck Surgery · doi:10.3342/kjorl-hns.2013.56.8.501 · Cited by 9
Expression of Chloride Channel Protein CLC-3 in Patients With Allergic Rhinitis
Li, H., Wen, W., Cheng, L., Shi, J., Jiang, H., Oh, Y. W., & Xu, G. (2008) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archoto.2007.45 · Cited by 8
Parker, J. C., Thavagnanam, S., Skibiński, G., McBrien, M. E., Heaney, L. G., & Shields, M. D. (2012) · Results in Immunology · doi:10.1016/j.rinim.2012.05.001 · Cited by 7
Plant polysaccharides with anti-lung injury effects as a potential therapeutic strategy for COVID-19
Huang, P., Zhang, J., Duan, W., Jiao, J., Leng, A., & Qu, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.982893 · Cited by 6
Airway Mucus Hypersecretion in Asthma and COPD
Rogers, D. F. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374001-4.00017-1 · Cited by 7
Kim, M., Lee, J., Ku, M.-U., Kim, K.-Y., Shin, S. K., Hong, E.-J., Ku, S., & Choi, J. (2023) · Applied Sciences · doi:10.3390/app13179578 · Cited by 5
Zou, L., Li, W., Han, J., Yang, Y., Jin, J., Xiao, F., Xu, X., & Zhai, Z. (2018) · Pulmonary Circulation · doi:10.1177/2045894018794374 · Cited by 5
Lee, J., Park, S., Kim, Y.-M., Guk, T., Choi, J. K., Kim, J.-Y., Lee, M.-Y., Jang, M.-K., & Park, S. (2022) · Antibiotics · doi:10.3390/antibiotics11121779 · Cited by 5
Voynow, J. A., & Fischer, B. M. (2006) · Elsevier eBooks · doi:10.1016/b0-12-370879-6/00248-9 · Cited by 5
Self-citationGene Expression Profiles of the Immuno-Transcriptome in Equine Asthma
Padoan, E., Ferraresso, S., Pegolo, S., Barnini, C., Castagnaro, M., & Bargelloni, L. (2022) · Animals · doi:10.3390/ani13010004 · Cited by 4
Wang, X., Li, Q., Zhou, X., Кolosov, V. P., & Perelman, J. M. (2012) · BioMed Research International · doi:10.1155/2012/648170 · Cited by 5
Signal Transduction of MUC5AC Expression in Airway Mucus Hypersecretory Disease
Shim, J. J. (2003) · Tuberculosis & respiratory diseases · doi:10.4046/trd.2003.55.1.21 · Cited by 4
Kwak, S., Choi, Y. S., Na, H. G., Bae, C. H., Song, S., Kim, H. G., & Kim, Y. (2019) · Toxicology Research · doi:10.1039/c9tx00135b · Cited by 4
Lee, J., Mansoor, S., Lee, J., Chung, H., Kwon, Y.-S., Bashir, K. M. I., Choi, J., & Ku, S. (2024) · Applied Sciences · doi:10.3390/app15010099 · Cited by 3
Chronic obstructive pulmonary disease and diseases of the airways
Timens, W., Sietsma, H., & Wright, J. L. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139018760.020 · Cited by 3
Validation of antibody reagents for mucin analysis in chronic inflammatory airway diseases
Krause, T., Röckendorf, N., Gaede, K. I., Ramaker, K., Sinnecker, H., & Frey, A. (2016) · mAbs · doi:10.1080/19420862.2016.1264551 · Cited by 3
Severe Atelectasis due to Aspirated Valproic Acid Tablet
Tanigaki, T., Ogawa, T., Nomura, S., Ito, K., Kurata, Y., Matsukida, A., Ishihara, M., Yoshino, A., Kawana, A., & Kimizuka, Y. (2024) · Case Reports in Pulmonology · doi:10.1155/2024/6650141 · Cited by 2
Analysis of the novel VNTR polymorphisms ofMUC8 gene
Lee, J., Kim, J.-Y., Ahn, E.-K., Lee, S.-Y., Jeong, Y. H., Lee, S.-R., & Leem, S. (2009) · Genes & Genomics · doi:10.1007/bf03191195 · Cited by 2
Airway Epithelial Mucins and Mucous Hypersecretion
Nadel, J. A. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-4710-0.00011-0 · Cited by 2
Effects of Inhaled Toxicants on the Nose and Nasal Function
Dalton, P., & Opiekum, R. (2005) · CRC Press eBooks · doi:10.1201/9781420037302.ch17 · Cited by 2
In search for the Holy Grail of cough guidelines
Chang, A. B. (2016) · Annals of Translational Medicine · doi:10.21037/atm.2016.12.55 · Cited by 2
Human Enterovirus D68 infection – the intricate dance of cells, genes, and invading bugs
Ørstenvik, H. L., Tveten, A., & Cao, Y. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1667268 · Cited by 1
Jeong, J., Cha, H., & Song, K. S. (2014) · Genes & Genomics · doi:10.1007/s13258-014-0203-z · Cited by 1
Airway Epithelium and Mucous Secretion
Nadel, J. A. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-3383-5.00010-5 · Cited by 1
Soga, K., Yamada, M., Naito, Y., Yoshikawa, T., & Arizono, N. (2013) · ISRN Parasitology · doi:10.5402/2013/804585 · Cited by 1
Effect of High-Insulin on MUC4, MUC5AC, and MUC5B Expression in Airway Epithelial Cells
Na, H. G., Bae, C. H., Choi, Y. S., Song, S., Jin, H. J., & Kim, Y. (2016) · Journal of rhinology · doi:10.18787/jr.2016.23.1.17 · Cited by 1
Foster, K., Adams, E. J., & Rogers, D. F. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4928-9.00028-7 · Cited by 1
Antón, M., & Asunción, M. (2008) · TDX (Tesis Doctorals en Xarxa)
Innate Immunity of Airway Epithelium and COPD
Ganesan, S., & Shanmugasundaram, U. (2012) · InTech eBooks · doi:10.5772/30828
hCLCA1 DNA Vaccine Suppresses Cell Hyperplasia and Mucin Expression of Goblet Cells in vitro
Song, L., Li, Y., Li, W., Zhang, W., Yang, Y. Q., & Qi, H. W. (2013) · Respiration · doi:10.1159/000354180
Kim, Y.-S., & Song, K. S. (2013) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-013-0372-x
The biochemical characterisation of respiratory mucus & mucins in normal, asthma & COPD
Trimmel, A. J. (2009) · Open University of Cape Town (University of Cape Town)
SUPPRESSIVE EFFECTS OF WELSH ONION EXTRACTS ON MUCUS HYPER-PRODUCTION IN HUMAN AIRWAY CELLS
Takashima, A. (2016) · Lettters in Health & Biological Sciences · doi:10.15436/2475-6245.16.011
Characterization of Murine Intestinal Mucus Layer Gene Expression during Postnatal Maturation
Lin, A. (2011) · TSpace (University of Toronto)
Role of Mucin 19 in the Respiratory Tract
McBride, K. (2018) · doi:10.31390/gradschool_theses.4665
Jeong, Y.-E., & Kim, J.-D. (2022) · The Journal of Internal Korean Medicine · doi:10.22246/jikm.2022.43.4.503
Effect of Uneven Microclimates in Poultry Yards on the Respiratory System of Poultry
Викторович, М. В., & Cherepanova, N. G. (2023) · Timiryazev Biological Journal · doi:10.26897/2949-4710-2023-1-23-28
HX110B Alleviates Excessive Cough and Sputum Overproduction via Downregulation of MUC5AC and MUC5B
Kim, E., Song, J., Lee, J., Choi, S., Jeong, Y., Park, J.-H., Lee, C. H., Nam, I.-J., Lee, H. M., Jeong, S., et al. (2025) · Natural Product Communications · doi:10.1177/1934578x251318123
Cavalcante, A. S., Lacerda, R. R. E., Campos, C. V., Capetini, V. C., da Conceição, Y. R. S., Bordin, S. A., Riffo‐Vasquez, Y., & Anhê, G. F. (2026) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2026.110286
Choi, W., Kośmider, B., & Lau, G. W. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27198882
Metadata
- Authors
- Rose, M. C., Nickola, T. J., & Voynow, J. A.
- Affiliations
- Duke University (US)
- ORCID
- Voynow, Judith A.
- Venue
- American Journal of Respiratory Cell and Molecular Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-11-01
- Volume
- 25
- Issue
- 5
- Pages
- 533-537
- ISSN
- 1044-1549 (ISSN-L)
- 1535-4989
- OpenAlex
- W2168675532
- Cited by
- 157
- References
- 58
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 7 · 2021: 1 · 2020: 2 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 8 · 2015: 8 · 2014: 7 · 2013: 10 · 2012: 14
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory Cell and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Keywords
- airway mucus, mucus obstruction, mucin glycoproteins, goblet cell hyperplasia, MUC5B, mucus overproduction, airway epithelium, respiratory inflammation, cystic fibrosis, asthma, bronchitis, sinusitis
- MeSH terms
- Airway Obstruction, Gene Expression Regulation, Glycoproteins, Humans, Hyperplasia, Mucins, Mucus, Goblet Cells, Respiratory Mucosa
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
