The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Airway Mucus Obstruction: Mucin Glycoproteins, MUC Gene Regulation and Goblet Cell Hyperplasia
Abstract
The mucus layer that coats the airway epithelium provides a protective barrier against pathogenic and noxious agents and participates in the mucosal response to inflammation and infection. Airway mucus is composed of water, ions, lung secretions, serum protein transudates, and mucin glycoproteins (mucins). Mucins are the major components of mucus and the macromolecules that impart rheologic properties to airway mucus (1, 2). Airway mucus is overproduced in the upper and/or lower respiratory tracts during acute challenges and in chronic conditions (asthma, cystic fibrosis, bronchitis, and sinusitis), thereby contributing to mucus obstruction of the airways (3). Mucus obstruction is the culmination of several complex processes including mucin ( MUC ) gene regulation, mucin secretion and goblet cell hyperplasia (GCH) (Figure 1). Insight into each of these processes is limited; more detailed information about fundamental cellular mechanisms will be required to better understand their interrelationships. For example, pathogenic agents and inflammatory mediators initiate secretion of mucins (4–7) and sustain mucin production by increasing expression of mucin genes (8, 9). Nevertheless, each process has markedly different kinetics and their response to mediators likely involves different cellular signaling and pathways. The increasing availability of molecular probes for specific mucin genes and gene products is beginning to provide some insights into the pathogenesis of mucus overproduction. However, detailed information about the expression and regulation of respiratory tract mucins in specific disease entities is still incomplete. The report by Chen and colleagues (10) provides new information on altered expression of a specific mucin gene, MUC5B.
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“Adherence of S. aureus and Bordetella pertussis to Hep-2 (human epidermoid cancer) epithelial cells was found in greater quantities for cells infected with RSV than for noninfected cells (240, 241)”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [241]
Citations
Cites
Interleukin-13: Central Mediator of Allergic Asthma
Wills-Karp, M. A., Luyimbazi, J., Xu, X., Schofield, B., Neben, T. Y., Karp, C. L., & Donaldson, D. D. (1998) · Science · doi:10.1126/science.282.5397.2258 · Cited by 2,611
Requirement for IL-13 Independently of IL-4 in Experimental Asthma
Grünig, G., Warnock, M. L., Wakil, A. E., Venkayya, R., Brombacher, F., Rennick, D. M., Sheppard, D., Mohrs, M., Donaldson, D. D., Locksley, R. M., et al. (1998) · Science · doi:10.1126/science.282.5397.2261 · Cited by 1,845
IMMUNOLOGIC BASIS OF ANTIGEN-INDUCED AIRWAY HYPERRESPONSIVENESS
Wills-Karp, M. A. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.255 · Cited by 1,022
Gendler, S. J., & Spicer, A. P. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.003135 · Cited by 1,001
Ordoñez, C. L., Khashayar, R., Wong, H. H., Ferrando, R., Wu, R., Hyde, D. M., Hotchkiss, J. A., ZHANG, Y., Novikov, A. A., Dolganov, G., et al. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.2.2004039 · Cited by 577
Airway goblet cells: responsive and adaptable front-line defenders
Rogers, D. (1994) · European Respiratory Journal · doi:10.1183/09031936.94.07091690 · Cited by 561
Audie, J. P., Janin, A., Porchet, N., Copin, M., Gosselin, B. H., & Aubert, J. (1993) · Journal of Histochemistry & Cytochemistry · doi:10.1177/41.10.8245407 · Cited by 458
MUC13, a Novel Human Cell Surface Mucin Expressed by Epithelial and Hemopoietic Cells
Williams, S. J., Wreschner, D. H., Tran, M. H., Eyre, H. J., Sutherland, G. R., & McGuckin, M. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008850200 · Cited by 329
Wickström, C., Davies, J. R., Eriksen, G. V., Veerman, E. C. I., & Carlstedt, I. (1998) · Biochemical Journal · doi:10.1042/bj3340685 · Cited by 315
Two novel mucin genes down-regulated in colorectal cancer identified by differential display.
Williams, S. J., McGuckin, M. A., Gotley, D. C., Eyre, H. J., Sutherland, G. R., & Antalis, T. (1999) · PubMed · Cited by 300
Cited by
Sorted by citations
Respiratory Tract Mucin Genes and Mucin Glycoproteins in Health and Disease
Rose, M. C., & Voynow, J. A. (2005) · Physiological Reviews · doi:10.1152/physrev.00010.2005 · Cited by 1,061
Self-citationRapid transport of large polymeric nanoparticles in fresh undiluted human mucus
Lai, S. K., O'Hanlon, D. E., Harrold, S., Man, S. T., Wang, Y.-Y., Cone, R., & Hanes, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608611104 · Cited by 1,050
The airway epithelium: soldier in the fight against respiratory viruses
Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655
Cho, S. J., & Stout-Delgado, H. W. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034610 · Cited by 458
Barrier function of airway tract epithelium
Ganesan, S., Comstock, A. T., & Sajjan, U. S. (2013) · Tissue Barriers · doi:10.4161/tisb.24997 · Cited by 366
Metadata
- Authors
- Rose, M. C., Nickola, T. J., & Voynow, J. A.
- Affiliations
- Duke University (US)
- ORCID
- Voynow, Judith A.
- Venue
- American Journal of Respiratory Cell and Molecular Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-11-01
- Volume
- 25
- Issue
- 5
- Pages
- 533-537
- ISSN
- 1044-1549 (ISSN-L)
- 1535-4989
- OpenAlex
- W2168675532
- Cited by
- 157
- References
- 58
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 7 · 2021: 1 · 2020: 2 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 8 · 2015: 8 · 2014: 7 · 2013: 10 · 2012: 14
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory Cell and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Keywords
- airway mucus, mucus obstruction, mucin glycoproteins, goblet cell hyperplasia, MUC5B, mucus overproduction, airway epithelium, respiratory inflammation, cystic fibrosis, asthma, bronchitis, sinusitis
- MeSH terms
- Airway Obstruction, Gene Expression Regulation, Glycoproteins, Humans, Hyperplasia, Mucins, Mucus, Goblet Cells, Respiratory Mucosa
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