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Pulmonary Bombesin and Calcitonin in Hamsters during Exposure to Hyperoxia and Diethylnitrosamine
Abstract
Combined exposure of hamsters to 60% hyperoxia and the carcinogen diethylnitrosamine for 6 wk resulted in the development of lung tumors. This was associated with progressive loss of body weight as well as increases in the pulmonary-associated peptides, mammalian bombesin (MB) and immunoreactive calcitonin (iCT). After 3 wk of exposure, multiple bronchial epithelial hyperplastic foci were noted, along with increased lung levels of MB and iCT as well as increased serum levels of MB. At this time, immunocyto-chemistry revealed the presence of MB and iCT within hyperplastic pulmonary neuroendocrine (PNE) cells. In addition, the localization of MB to alveolar type II cells was noted, along with the presence of lamellar bodies and secretion granules in these cells on electron microscopy. After 6 wk of exposure, distinctive microscopic pulmonary tumorlets were seen. These tumorlets were associated with a marked increase in lung and serum MB, and to a lesser extent lung and serum iCT. At this time, MB and iCT were localized exclusively to these abnormal PNE cell sites. These results, which may have relevance in humans, suggest that endogenous peptides may be important components in the process of development of neuroendocrine cancer.
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Different groups observed that respiration hyperoxia can act as a promoting stimulus to induce lung tumorigenesis of neuroendocrine tumors.
“Conversely, different groups have observed that respiration hyperoxia can act as a promoting stimulus to induce lung tumorigenesis of neuroendocrine tumors.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [290]
Citations
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Hypoxia signaling in cancer: Implications for therapeutic interventions
Zhuang, Y., Liu, K., He, Q., Gu, X., Jiang, C., & Wu, J. (2023) · MedComm · doi:10.1002/mco2.203 · Cited by 119
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Self-citation
Metadata
- Authors
- Nylen, E. S., Becker, K. L., Joshi, P. A., Snider, R. H., & Schuller, H. M.
- Affiliations
- George Washington University (US)
- Corresponding author
- Nylen, Eric S.
- ORCID
- Nylen, Eric S.
- Venue
- American Journal of Respiratory Cell and Molecular Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-01-01
- Volume
- 2
- Issue
- 1
- Pages
- 25-31
- ISSN
- 1044-1549 (ISSN-L)
- 1535-4989
- OpenAlex
- W1983941106
- Cited by
- 20
- References
- 30
- Citations by year
- 2023: 1
- FWCI
- 4.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory Cell and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (1RO1CA-HL48014-01PTHB)
- Topics
- Health Sciences › Medicine › Oncology › Neuroendocrine Tumor Research Advances
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Oncology › Lung Cancer Research Studies
- Keywords
- bombesin, calcitonin, hyperoxia, diethylnitrosamine, lung cancer, pulmonary neuroendocrine cells, alveolar type II cells, endogenous peptides, hamster
- MeSH terms
- Animals, Body Weight, Bombesin, Calcitonin, Chromatography, High Pressure Liquid, Cytoplasmic Granules, Diethylnitrosamine, Cricetinae, Immunohistochemistry, Lung, Lung Neoplasms, Male, Mesocricetus, Neurosecretory Systems, Oxygen, Pulmonary Alveoli
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