The DOI matches its Crossref record.
Folic Acid Conjugated Guar Gum Nanoparticles for Targeting Methotrexate to Colon Cancer
Abstract
It was envisaged to develop surface modified Guar Gum Nanoparticles (GGNP) with Folic acid (FA) charged with methotrexate (MTX) to target the colon specifically. The MTX loaded FA functionalized GGNP (MTX-FA-GGNP) have been prepared by emulsion crosslinking method. These surface modified nanoparticles were compared with unmodified MTX loaded GGNP (MTX-GGNP). The developed formulations were evaluated for size and size distribution, zeta potential, Differential Scanning Calorimetry (DSC), release profile and uptake studies. The nanoparticles have been found to have average size of 325 nm in diameter having polydispersity index (PDI) 0.177 indicating mono-disperse particles. The zeta potential of the particles was found to be -36.9 mV. The percent growth inhibition of Caco 2 cells with MTX-FA-GGNP was found to be better than MTX-GGNP indicating folate receptor mediated uptake. The MTX-GGNP protects the release of MTX in upper gastrointestinal tract while maximum release of MTX occurred in simulated colonic fluids of pH 6.8. The in vivo uptake studies revealed preferential uptake of nanoparticles formulation in the colon. These studies provide evidences that MTX-FA-GGNP holds promise to address colorectal cancer over-expressing folate receptors. This prototype formulation enjoys dual advantage of having propensity to release the drug in the colon and in the conditions of colorectal carcinoma; it could be better localized and targeted with improved therapy due to over-expression of folate receptors.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Citations
Cites
Still being checked.
Cited by
Sorted by citations
Banerjee, A., Pathak, S., Subramanium, V. D., G., D., Murugesan, R., & Verma, R. S. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.05.006 · Cited by 204
Current-status and applications of polysaccharides in drug delivery systems
Prasher, P., Sharma, M., Mehta, M., Satija, S., Aljabali, A. A. A., Tambuwala, M. M., Anand, K., Sharma, N., Dureja, H., Jha, N. K., et al. (2021) · Colloids and Interface Science Communications · doi:10.1016/j.colcom.2021.100418 · Cited by 175
Self-citationTargeted Nanoparticles for Colorectal Cancer
Cisterna, B. A., Kamaly, N., Choi, W. I., Tavakkoli, A., Farokhzad, O. C., & Vilos, C. (2016) · Nanomedicine · doi:10.2217/nnm-2016-0194 · Cited by 174
Insight to drug delivery aspects for colorectal cancer
Gulbake, A. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i2.582 · Cited by 156
Tahir, N., Madni, A., Balasubramanian, V., Rehman, M., Correia, A., Kashif, P. M., Mäkilä, E. M., Salonen, J., & Santos, H. A. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.09.061 · Cited by 144
Metadata
- Authors
- Sharma, M., Malik, R., Verma, A., Dwivedi, P., Banoth, G. S., Pandey, N., Sarkar, J., Mishra, P. R., & Dwivedi, A. K.
- Affiliations
- Central Drug Research Institute (IN)
- Venue
- Journal of Biomedical Nanotechnology
- Publisher
- American Scientific Publishers
- Published
- 2013-01-01
- Volume
- 9
- Issue
- 1
- Pages
- 96-106
- ISSN
- 1550-7033 (ISSN-L)
- OpenAlex
- W2063455557
- Cited by
- 85
- References
- 0
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 18 · 2020: 5 · 2019: 8 · 2018: 3 · 2017: 8 · 2016: 6 · 2015: 3 · 2014: 7 · 2013: 2
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Nanotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- folic acid, methotrexate, colon cancer, folate receptor targeting, targeted drug delivery, colon-specific drug release, emulsion cross-linking, Caco-2 cell uptake, colorectal cancer, nanoparticle surface modification
- MeSH terms
- Animals, Calorimetry, Differential Scanning, Cell Survival, Colonic Neoplasms, Cross-Linking Reagents, Folic Acid, Galactans, Humans, Mannans, Methotrexate, Magnetic Resonance Spectroscopy, Particle Size, Drug Delivery Systems, Rats, Wistar, Spectroscopy, Fourier Transform Infrared, Caco-2 Cells, Rats, Plant Gums, Nanoparticles, Static Electricity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
