Redox-Responsive Amphipathic Dextran Nanomicelles for Solid Tumor Therapy
Abstract
A disulfide bond containing deoxycholic acid-grafted dextran (Dex-SSDCA) was successfully prepared for drug delivery. The Dex-SSDCA polymers can self-assemble into nanomicelles at concentrations below 56 g/mL and encapsulate doxorubicin (DOX) effectively. When exposed to 10 mM Dithiothreitol (DTT), the nanomicelles disassembled rapidly and released DOX immediately. The DOX-loaded Dex-SSDCA nanomicelles were able to reverse the drug resistance of MCF-7/Adr cells and inhibit their growth in vitro. Moreover, DOX-loaded Dex-SSDCA nanomicelles could significantly suppress the growth of subcutaneous SKOV-3 ovarian cancer in vivo, exerting stronger efficiency on inhibiting tumor angiogenesis and proliferation while aggravating apoptosis of tumor cells, in comparison with the negative control and free DOX. The in vivo toxicity evaluation demonstrated that the Dex-SSDCA micelles reduced DOX-induced side effects. This redoxresponsive amphipathic dextran is able to enhance the antitumor efficiency and reduce the toxicity of doxorubicin, thus has a potential as a drug carrier for cancer therapy.
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The polymer was prone to self-assemble and form nanomicelles at concentrations less than 56 g/mL and could efficiently encapsulate DOX.
“The polymer was prone to self-assemble and form nanomicelles at concentrations less than 56 g/mL and could efficiently encapsulate DOX.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [220]
Alternative nanocarrier for drug delivery was fabricated with deoxycholic acid-grafted dextran (Dex-SSDCA) containing a disulfide bond.
“Alternative nanocarrier for drug delivery was fabricated with deoxycholic acid-grafted dextran (Dex-SSDCA) containing a disulfide bond [220].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [220]
Rapid disassembly was observed upon exposure to 10 mM Dithiothreitol (DTT) which led to the immediate release of DOX.
“Rapid disassembly was observed upon exposure to 10 mM Dithiothreitol (DTT) which led to the immediate release of DOX.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [220]
This drug delivery system demonstrated in vivo significant suppression of subcutaneous SKOV-3 ovarian cancer cells with notable inhibition of tumor angiogenesis and proliferation and enhanced apoptosis when compared with free DOX and negative control.
“This drug delivery system demonstrated in vivo significant suppression of subcutaneous SKOV-3 ovarian cancer cells with notable inhibition of tumor angiogenesis and proliferation and enhanced apoptosis when compared with free DOX and negative control.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [220]
In vitro studies showed that DOX-loaded Dex-SSDCA nanomicelles considerably diminished drug resistance of MCF-7/Adr cells and inhibited their growth.
“In vitro studies showed that DOX-loaded Dex-SSDCA nanomicelles considerably diminished drug resistance of MCF-7/Adr cells and inhibited their growth.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [220]
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- Authors
- Song, Y., Lou, B., Cheng, J., Zhao, P., Lin, C., & Wen, X.
- Venue
- Journal of Biomedical Nanotechnology
- Publisher
- American Scientific Publishers
- Published
- 2016-12-01
- Volume
- 12
- Issue
- 12
- Pages
- 2083-2096
- ISSN
- 1550-7033 (ISSN-L)
- OpenAlex
- W2547780699
- Cited by
- 32
- References
- 0
- Citations by year
- 2026: 3 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 11
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Nanotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- disulfide bonds, doxorubicin delivery, drug resistance reversal, MCF-7/ADR cells, ovarian cancer, tumor angiogenesis, apoptosis, drug toxicity reduction, self-assembly
- MeSH terms
- Animals, Antineoplastic Agents, Cell Survival, Dextrans, Dithiothreitol, Doxorubicin, Drug Carriers, Humans, Male, Mice, Nude, Micelles, Oxidation-Reduction, Apoptosis, Xenograft Model Antitumor Assays, Cell Line, Tumor, Mice, Nanoparticles, MCF-7 Cells
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