Self-Assembled Hyaluronic Acid Nanoparticles for pH-Sensitive Release of Doxorubicin: Synthesis and In Vitro Characterization
Abstract
. In the aspect of nanostructure, the polymer prodrug can self-assembly into the core-shell structure nanoparticles in aqueous solution with the hyaluronic acid as the hydrophilic shell and doxorubicin as the hydrophobic core. By optimizing the process of preparation, nanoparticles showed the mean size of around 200 nm and a narrow particle size distribution which were verified by dynamic light scattering (DLS) and transmission electron microscopy (TEM). CCK-8 assays and fluorescence microscope experiments showed that the polymer prodrug nanoparticles possessed an enhanced targeting ability and antitumor activity toward HeLa cells.
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Polymeric micelles formed by amphiphilic block copolymers have gained attention due to their core/shell structure, excellent stability, and ideal encapsulation and delivery efficiency of hydrophobic drugs.
“Among them, polymeric micelles formed by amphiphilic block copolymers have gained more attention due to their unique properties such as the core/shell structure, excellent stability, and ideal encapsulation and delivery efficiency of hydrophobic drugs.34–37”
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- Authors
- Hu, R., Zheng, H., Cao, J., Davoudi, Z., & Wang, Q.
- Venue
- Journal of Biomedical Nanotechnology
- Publisher
- American Scientific Publishers
- Published
- 2017-12-01
- Volume
- 13
- Issue
- 9
- Pages
- 1058-1068
- ISSN
- 1550-7033 (ISSN-L)
- OpenAlex
- W2774509732
- Cited by
- 57
- References
- 0
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 6 · 2020: 8 · 2019: 16 · 2018: 13
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Nanotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- hyaluronic acid, doxorubicin, self-assembly, core-shell nanoparticles, pH-responsive drug release, polymer prodrugs, tumor targeting, anticancer activity, HeLa cells, drug delivery
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