The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Expression of VLDLR in the Retina and Evolution of Subretinal Neovascularization in the Knockout Mouse Model’s Retinal Angiomatous Proliferation
Abstract
Purpose Very-low-density lipoprotein receptor (VLDLR) in knockout mice (vldlr(-/-)) has been reported to induce subretinal neovascularization. Therefore, VLDLR expression in the wild-type mouse retina was investigated and the retinal angiogenic process in vldlr(-/-) mice was characterized. Methods VLDLR expression in the retina and in purified retinal vascular endothelial cells (RECs) and retinal pigment epithelial (RPE) cells was determined by reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry. Angiogenic evolution in vldlr(-/-) mice was examined by fundus fluorescein angiography, histology, double-staining of FITC-dextran perfusion and elastin immunohistochemistry, isolectin staining, and confocal fluorescence microscopy. Results VLDLR mRNA was detected in the wild-type mouse retina and in purified RECs and RPE cells. The VLDLR protein was localized in the RPE layer, vessels in the ganglion cell layer, and around the outer limiting membrane of the retina. The retinal pathogenic process in vldlr(-/-) mice recapitulates key features of retinal angiomatous proliferation (RAP) in humans, a subtype of neovascular age-related macular degeneration (AMD). These include neovascular growth originating from retinal vessels and progressing to the subretinal space with intraretinal, subretinal, and choroidal angiogenic stages, RPE disruption and Bruch membrane exposure, retinal-choroidal anastomosis, subsequent photoreceptor degeneration, RPE hyperplasia,…
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RPE cells have endogenous VLDLR expression.
“although RPE cells have endogenous VLDLR expression (33)”
From ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium (2021) · cites this paper as [33]
Citations
Cites
Hiesberger, T., Trommsdorff, M., Howell, B. W., Goffinet, A., Mumby, M. C., Cooper, J. A., & Herz, J. (1999) · Neuron · doi:10.1016/s0896-6273(00)80861-2 · Cited by 916
Pathogenesis of lesions in late age-related macular disease
Holz, F. G., Pauleikhoff, D., Klein, R., & Bird, A. C. (2004) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2003.11.026 · Cited by 203
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A new perspective on lipid research in age-related macular degeneration
van Leeuwen, E. M., Emri, E., Merle, B. M. J., Colijn, J. M., Kersten, E., Cougnard-Gregoire, A., Dammeier, S., Meester-Smoor, M., Pool, F. M., de Jong, E. K., et al. (2018) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.04.006 · Cited by 247
Dorrell, M. I., Aguilar, E., Jacobson, R., Yanes, O., Gariano, R., Heckenlively, J., Banin, E., Ramirez, G. A., Gasmi, M., Bird, A., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci35977 · Cited by 127
Genetics of age-related macular degeneration: current concepts, future directions
DeAngelis, M. M., Silveira, A. C., Carr, E. A., & Kim, I. K. (2011) · Seminars in Ophthalmology · doi:10.3109/08820538.2011.577129 · Cited by 94
Kyosseva, S. V., Chen, L., Seal, S., & McGinnis, J. F. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.08.003 · Cited by 82
ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium
Ma, X., Takahashi, Y., Wu, W., Liang, W., Chen, J., Chakraborty, D., Li, Y., Du, Y., Benyajati, S., & Ma, J.-X. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101185 · Cited by 9
Metadata
- Authors
- Hu, W., Jiang, A., Liang, J., Meng, H., Chang, B., Gao, H., & Qiao, X.
- Affiliations
- From the Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana; and the
- Jackson Laboratory, Bar Harbor, Maine.
- Venue
- Investigative Opthalmology & Visual Science
- Published
- 2008-01-01
- Volume
- 49
- Issue
- 1
- Pages
- 407
- ISSN
- 1552-5783
- Cited by
- 117
- References
- 2
- Language
- en
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