Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress

Dorrell, Michael I.; Aguilar, Edith; Jacobson, Ruth; Yanes, Oscar; Gariano, Ray; Heckenlively, John; Banin, Eyal; Ramirez, G. Anthony; Gasmi, Mehdi; Bird, Alan; Siuzdak, Gary; Friedlander, Martin

doi:10.1172/jci35977

Cited by 127Retinal Diseases and TreatmentsRetinal Development and DisordersRetinal Imaging and Analysis

Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress

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Dorrell, Michael I., Aguilar, Edith, Jacobson, Ruth, Yanes, Oscar, Gariano, Ray, Heckenlively, John, Banin, Eyal, Ramirez, G. Anthony +4 more·2009·Journal of Clinical Investigation

DOI 10.1172/jci35977PMC PMC2648679

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Abstract

In several disease states, abnormal growth of blood vessels is associated with local neuronal degeneration. This is particularly true in ocular diseases such as retinal angiomatous proliferation (RAP) and macular telangiectasia (MacTel), in which, despite the absence of large-scale leakage or hemorrhage, abnormal neovascularization (NV) is associated with local neuronal dysfunction. We describe here a retinal phenotype in mice with dysfunctional receptors for VLDL (Vldlr-/- mice) that closely resembles human retinal diseases in which abnormal intra- and subretinal NV is associated with photoreceptor cell death. Such cell death was evidenced by decreased cone and, to a lesser extent, rod opsin expression and abnormal electroretinograms. Cell death in the region of intraretinal vascular abnormalities was associated with an increased presence of markers associated with oxidative stress. Oral antioxidant supplementation protected against photoreceptor degeneration and preserved retinal function, despite the continued presence of abnormal intra- and subretinal vessels. What we believe to be novel, Müller cell-based, virally mediated delivery of neurotrophic compounds specifically to sites of NV was also neuroprotective. These observations demonstrate that neuronal loss secondary to NV can be prevented by the use of simple antioxidant dietary measures or cell-based delivery of neurotrophic factors, even when the underlying vascular phenotype is not altered.

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Stress (GFAP promoter) or hypoxia-driven GFAP promoters (HRSE-6xHRE-GfaABC1D) have been generated that might be safer for cells that are sensitive to continuous overexpressed artificial gene vectors.
“Stress (GFAP promoter) or hypoxia-driven GFAP promoters (HRSE-6xHRE-GfaABC1D) have been generated that might be safer for cells that are sensitive to continuous overexpressed artificial gene vectors [96,97,99,100,102].”
From Recombinant Adeno-Associated Viral Vectors (rAAV)-Vector Elements in Ocular Gene Therapy Clinical Trials and Transgene Expression and Bioactivity Assays (2020) · cites this paper as [100]
The vector-construction methods describe a GFAP-promoter AAV vector, and the Results show that it targeted activated Müller glia near retinal neovascularization. The paper does not describe the named hypoxia-driven promoter or establish that these vectors are safer for cells sensitive to continuous overexpression. (LLM, conf=0.86)
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(2001) · Archives of Ophthalmology · doi:10.1001/archopht.119.10.1417 · Cited by 3,285 · see citing works
Angiogenesis as a therapeutic target
Ferrara, N., & Kerbel, R. S. (2005) · Nature · doi:10.1038/nature04483 · Cited by 2,653 · see citing works
Reeler/Disabled-like Disruption of Neuronal Migration in Knockout Mice Lacking the VLDL Receptor and ApoE Receptor 2
Trommsdorff, M., Gotthardt, M., Hiesberger, T., Shelton, J., Stockinger, W., Nimpf, J., Hammer, R. E., Richardson, J. A., & Herz, J. (1999) · Cell · doi:10.1016/s0092-8674(00)80782-5 · Cited by 1,261 · see citing works
The epidemiology of age-related macular degeneration
Klein, R., Peto, T., Bird, A., & Vannewkirk, M. R. (2004) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2003.11.069 · Cited by 932 · see citing works
Self-citation
RETINAL ANGIOMATOUS PROLIFERATION IN AGE–RELATED MACULAR DEGENERATION
Yannuzzi, L. A., Negrão, S., Iida, T., CARVALHO, C., Rodriguez-Coleman, H., Slakter, J. S., Freund, K. B., Sorenson, J. A., Orlock, D. A., & Borodoker, N. (2012) · Retina · doi:10.1097/iae.0b013e31823f9b3b · Cited by 660 · see citing works
RETINAL ANGIOMATOUS PROLIFERATION IN AGE-RELATED MACULAR DEGENERATION
Yannuzzi, L. A., Negrão, S., Iida, T., CARVALHO, C., Rodriguez-Coleman, H., Slakter, J. S., Freund, K. B., Sorenson, J. A., Orlock, D. A., & Borodoker, N. (2001) · Retina · doi:10.1097/00006982-200110000-00003 · Cited by 658 · see citing works
Protein-bound acrolein: Potential markers for oxidative stress
Uchida, K., Kanematsu, M., Sakai, K., Matsuda, T., Hattori, N., Mizuno, Y., Suzuki, D., Miyata, T., Noguchi, N., Niki, E., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.4882 · Cited by 632 · see citing works
Involvement of oxidative stress in Alzheimer disease
Nunomura, A., Castellani, R. J., Zhu, X., Moreira, P. I., Perry, G., & Smith, M. A. (2006) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/01.jnen.0000228136.58062.bf · Cited by 611 · see citing works
A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E and Beta Carotene for Age-Related Cataract and Vision Loss
(2001) · Archives of Ophthalmology · doi:10.1001/archopht.119.10.1439 · Cited by 547 · see citing works
Idiopathic juxtafoveolar retinal telangiectasis. Update of classification and follow-up study.
Gass, J. D. M., & Blodi, B. A. (1993) · PubMed · Cited by 507 · see citing works
Idiopathic Macular Telangiectasia
Yannuzzi, L. A. (2006) · Archives of Ophthalmology · doi:10.1001/archopht.124.4.450 · Cited by 473 · see citing works
Idiopathic Juxtafoveolar Retinal Telangiectasis
Gass, J. D. M., & Blodi, B. A. (1993) · Ophthalmology · doi:10.1016/s0161-6420(93)31447-8 · Cited by 462 · see citing works
Antioxidants reduce cone cell death in a model of retinitis pigmentosa
Komeima, K., Rogers, B. S., Lu, L., & Campochiaro, P. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604056103 · Cited by 420 · see citing works
Neuroinflammation and regulation of glial glutamate uptake in neurological disorders
Tilleux, S., & Hermans, E. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21325 · Cited by 381 · see citing works
THE ROLE OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN OCULAR HEALTH AND DISEASE
Adamis, A. P., & Shima, D. T. (2005) · Retina · doi:10.1097/00006982-200502000-00001 · Cited by 334 · see citing works
Retinal vascular development is mediated by endothelial filopodia, a preexisting astrocytic template and specific R-cadherin adhesion.
Dorrell, M. I., Aguilar, E., & Friedlander, M. (2002) · PubMed · Cited by 318 · see citing works
Self-citation
The role of VEGF in the regulation of physiological and pathological angiogenesis
Ferrara, N. (2005) · Birkhäuser Basel eBooks · doi:10.1007/3-7643-7311-3_15 · Cited by 313 · see citing works
Oxidative Damage in Huntington's Disease Pathogenesis
Browne, S. E., & Beal, M. F. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.2061 · Cited by 309 · see citing works
Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa
Shen, J., Yang, X., Dong, A., Petters, R. M., Peng, Y., Wong, F., & Campochiaro, P. A. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20346 · Cited by 300 · see citing works
Relationship between astrocytes, ganglion cells and vasculature of the retina
Stone, J., & Dreher, Z. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902550104 · Cited by 298 · see citing works
The Role of Neurotrophins in Axonal Growth, Guidance, and Regeneration
Lykissas, M. G., Batistatou, A. K., Charalabopoulos, K., & Beris, A. E. (2007) · Current Neurovascular Research · doi:10.2174/156720207780637216 · Cited by 268 · see citing works
PDGF Mediates a Neuron–Astrocyte Interaction in the Developing Retina
Fruttiger, M., Calver, A. R., Krueger, W. H., Mudhar, H. S., Michalovich, D., Takakura, N., Nishikawa, S. I., & Richardson, W. D. (1996) · Neuron · doi:10.1016/s0896-6273(00)80244-5 · Cited by 258 · see citing works
Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor.
Frykman, P. K., Brown, M. S., Yamamoto, T., Goldstein, J. L., & Herz, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.18.8453 · Cited by 256 · see citing works
Dual Effects of Antioxidants in Neurodegeneration: Direct Neuroprotection against Oxidative Stress and Indirect Protection via Suppression of Gliamediated Inflammation
Wang, J.-Y., Wen, L. L., Huang, Y.-N., Chen, Y.-T., & Ku, M.-C. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206778343109 · Cited by 250 · see citing works
Blood vessels change in the mesencephalon of patients with Parkinson's disease
Faucheux, B. A., Agid, Y., Hirsch, É. C., & Bonnet, A.-M. (1999) · The Lancet · doi:10.1016/s0140-6736(99)00641-8 · Cited by 218 · see citing works
Oxygen, the Lead Actor in the Pathophysiologic Drama: Enactment of the Trinity of Normoxia, Hypoxia, and Hyperoxia in Disease and Therapy
Kulkarni, A. C., Kuppusamy, P., & Parinandi, N. L. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1724 · Cited by 189 · see citing works
Vascular permeability in ocular disease and the role of tight junctions
Erickson, K. K., Sundstrom, J. M., & Antonetti, D. A. (2007) · Angiogenesis · doi:10.1007/s10456-007-9067-z · Cited by 188 · see citing works
Vascular oxidative stress in Alzheimer disease
Zhu, X., Smith, M. A., Honda, K., Aliev, G. M., Moreira, P. I., Nunomura, A., Casadesús, G., Harris, P. L. R., Siedlak, S. L., & Perry, G. L. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.01.039 · Cited by 175 · see citing works
Inducible expression of vascular endothelial growth factor in adult mice causes severe proliferative retinopathy and retinal detachment.
Ohno-Matsui, K., Hirose, A., Yamamoto, S., Saikia, J., Okamoto, N., Gehlbach, P., Duh, E., Hackett, S., Chang, M., Bok, D., et al. (2002) · American Journal of Pathology · doi:10.1016/s0002-9440(10)64891-2 · Cited by 171 · see citing works
Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: Involvement of the transcription factor Nrf2
Calabrese, V., Ravagna, A., Colombrita, C., Scapagnini, G., Guagliano, E., Calvani, M., Butterfield, D. A., & Stella, A. M. G. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20386 · Cited by 170 · see citing works
Vessels and Nerves: Marching to the Same Tune
Weinstein, B. M. (2005) · Cell · doi:10.1016/j.cell.2005.01.010 · Cited by 160 · see citing works
A fragment of human TrpRS as a potent antagonist of ocular angiogenesis
Otani, A., Slike, B. M., Dorrell, M. I., Hood, J. D., Kinder, K., Ewalt, K. L., Cheresh, D. A., SCHIMMEL, P. R., & Friedlander, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012601899 · Cited by 156 · see citing works
Self-citation
Striatal Delivery of Neurturin by CERE-120, an AAV2 Vector for the Treatment of Dopaminergic Neuron Degeneration in Parkinson's Disease
Gasmi, M., Herzog, C. D., Brandon, E. P., Cunningham, J. J., Ramirez, G. A., Ketchum, E. T., & Bartus, R. T. (2006) · Molecular Therapy · doi:10.1038/sj.mt.6300010 · Cited by 153 · see citing works
Self-citation
Oxidative damage in age-related macular degeneration.
Shen, J., Dong, A., Hackett, S. F., Bell, W. R., Green, W. R., & Campochiaro, P. A. (2007) · PubMed · doi:10.14670/hh-22.1301 · Cited by 152 · see citing works
MOUSE MODEL OF SUBRETINAL NEOVASCULARIZATION WITH CHOROIDAL ANASTOMOSIS
Heckenlively, J. R., Hawes, N. L., Friedlander, M., Nusinowitz, S., Hurd, R. E., Davisson, M. T., & Chang, B. (2003) · Retina · doi:10.1097/00006982-200308000-00012 · Cited by 151 · see citing works
Self-citation
Combination angiostatic therapy completely inhibits ocular and tumor angiogenesis
Dorrell, M. I., Aguilar, E., Scheppke, L., Barnett, F. H., & Friedlander, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607542104 · Cited by 147 · see citing works
Self-citation
Multiple interacting sites regulate astrocyte-specific transcription of the human gene for glial fibrillary acidic protein.
Besnard, F., Brenner, M., Nakatani, Y., Chao, R., Purohit, H. J., & Freese, E. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55145-0 · Cited by 146 · see citing works
Expression of VLDLR in the Retina and Evolution of Subretinal Neovascularization in the Knockout Mouse Model’s Retinal Angiomatous Proliferation
Hu, W., Jiang, A., Liang, J., Meng, H., Chang, B., Gao, H., & Qiao, X. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-0870 · Cited by 128 · see citing works
Acetylcarnitine and cellular stress response: roles in nutritional redox homeostasis and regulation of longevity genes
Calabrese, V., Stella, A. G., Calvani, M., & Butterfield, D. A. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.03.027 · Cited by 128 · see citing works
Comparison of the Effects of l‐Carnitine and Acetyl‐l‐Carnitine on Carnitine Levels, Ambulatory Activity, and Oxidative Stress Biomarkers in the Brain of Old Rats
Liu, J., Head, E., Kuratsune, H., Cotman, C. W., & Ames, B. N. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1320.011 · Cited by 120 · see citing works
Combination therapy for the treatment of ocular neovascularization
Bradley, J. M. B., Ju, M., & Robinson, G. S. (2007) · Angiogenesis · doi:10.1007/s10456-007-9069-x · Cited by 115 · see citing works
Very Low Density Lipoprotein Receptor, a Negative Regulator of the wnt Signaling Pathway and Choroidal Neovascularization
Chen, Y., Hu, Y., Lu, K., Flannery, J. G., & Ma, J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611289200 · Cited by 107 · see citing works
VE-cadherin Links tRNA Synthetase Cytokine to Anti-angiogenic Function
Tzima, E., Reader, J. S., Irani-Tehrani, M., Ewalt, K. L., Schwartz, M. A., & SCHIMMEL, P. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400431200 · Cited by 101 · see citing works
Findings in Fluorescein Angiography and Optical Coherence Tomography after Intravitreal Bevacizumab in Type 2 Idiopathic Macular Telangiectasia
Issa, P. C., Holz, F. G., & Scholl, H. P. N. (2007) · Ophthalmology · doi:10.1016/j.ophtha.2007.03.079 · Cited by 91 · see citing works
T2-TrpRS Inhibits Preretinal Neovascularization and Enhances Physiological Vascular Regrowth in OIR as Assessed by a New Method of Quantification
Banin, E., Dorrell, M. I., Aguilar, E., Ritter, M. R., Aderman, C. M., Smith, A. C. H., Friedlander, J., & Friedlander, M. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-1096 · Cited by 89 · see citing works
Self-citation
INTRAVITREAL BEVACIZUMAB (AVASTIN) FOR RETINAL ANGIOMATOUS PROLIFERATION
MEYERLE, C. B., Freund, K. B., Iturralde, D., Spaide, R. F., Sorenson, J. A., Slakter, J. S., Klancnik, J. M., Fisher, Y. L., Cooney, M. J., & Yannuzzi, L. A. (2007) · Retina · doi:10.1097/iae.0b013e318030ea80 · Cited by 88 · see citing works
Ulrastructural Immunocytochemistry of Subretinal Neovascular Membranes in Age-related Macular Degeneration
Das, A., Puklin, J. E., Frank, R. N., & Zhang, N. L. (1992) · Ophthalmology · doi:10.1016/s0161-6420(92)31792-0 · Cited by 67 · see citing works
Effects of Metabolic Modifiers Such as Carnitines, Coenzyme Q10, and PUFAs against Different Forms of Neurotoxic Insults: Metabolic Inhibitors, MPTP, and Methamphetamine
Virmani, A., Gaetani, F., & BINIENDA, Z. K. (2005) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2005.tb00024.x · Cited by 64 · see citing works
Biochemical Alterations in the Retinas of Very Low-Density Lipoprotein Receptor Knockout Mice
Li, C. (2007) · Archives of Ophthalmology · doi:10.1001/archopht.125.6.795 · Cited by 61 · see citing works
Adult bone marrow-derived stem cells use R-cadherin to target sites of neovascularization in the developing retina
Dorrell, M. I., Otani, A., Aguilar, E., Moreno, S. K., & Friedlander, M. (2004) · Blood · doi:10.1182/blood-2003-09-3012 · Cited by 54 · see citing works
Self-citation
Effects of Metabolic Modifiers Such as Carnitines, Coenzyme Q10, and PUFAs against Different Forms of Neurotoxic Insults: Metabolic Inhibitors, MPTP, and Methamphetamine
Virmani, A. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1344.016 · Cited by 45 · see citing works
Ischemia-Reperfusion-Related Repair Deficit after Oxidative Stress: Implications of Faulty Transcripts in Neuronal Sensitivity after Brain Injury
Liu, P. K. (2003) · Journal of Biomedical Science · doi:10.1007/bf02255992 · Cited by 44 · see citing works
Blood vessels and Parkinsonism
Barcia, C. (2004) · Frontiers in Bioscience · doi:10.2741/1145 · Cited by 41 · see citing works
Role of Neurotrophin-4/5 in Neural Cell Death during Retinal Development and Ischemic Retinal Injury In Vivo
Harada, C., Harada, T., Quah, H.-M. A., Namekata, K., Yoshida, K., Ohno, S., Tanaka, K., & Parada, L. F. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0826 · Cited by 36 · see citing works
Histopathologic Study of Presumed Parafoveal Telangiectasis
Gass, J. D. M. (2000) · Retina · doi:10.1097/00006982-200002000-00028 · Cited by 36 · see citing works
Macular Telangiectasia
Chew, E. Y. (2006) · Archives of Ophthalmology · doi:10.1001/archopht.124.4.573 · Cited by 17 · see citing works
Intravitreal triamcinolone and bevacizumab combination therapy for refractory choroidal neovascularization with retinal angiomatous proliferation
Bakri, S. J., & Ekdawi, N. S. (2007) · Eye · doi:10.1038/sj.eye.6703041 · Cited by 9 · see citing works
Evaluating Retinal Function in the Mouse Retina with the Electroretinogram
(2006) · The MIT Press eBooks · doi:10.7551/mitpress/5557.003.0105 · Cited by 7 · see citing works

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Issa, P. C., Gillies, M. C., Chew, E. Y., Bird, A. C., Heeren, T. F. C., Pető, T., Holz, F. G., & Scholl, H. P. N. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2012.11.002 · Cited by 396 · see citing works
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Joyal, J., Sun, Y., Gantner, M. L., Shao, Z., Evans, L. P., Saba, N., Fredrick, T. W., Burnim, S. B., Kim, J. S., Patel, G., et al. (2016) · Nature Medicine · doi:10.1038/nm.4059 · Cited by 265 · see citing works
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Joyal, J., Gantner, M. L., & Smith, L. E. H. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.11.002 · Cited by 186 · see citing works
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O’Carroll, S. J., Cook, W. H., & Young, D. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.618020 · Cited by 105 · see citing works
NLRP3 Inflammasome Blockade Inhibits VEGF-A-Induced Age-Related Macular Degeneration
Marneros, A. G. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.002 · Cited by 106 · see citing works
[WITHDRAWN] Retinal Vasculature in Development and Diseases
Sun, Y., & Smith, L. E. H. (2018) · Annual Review of Vision Science · doi:10.1146/annurev-vision-091517-034018 · Cited by 103 · see citing works
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The Pathogenic Role of the Canonical Wnt Pathway in Age-Related Macular Degeneration
Zhou, T., Hu, Y., Chen, Y., Zhou, K., Zhang, B., Gao, G., & Ma, J. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4278 · Cited by 102 · see citing works
Fatty acid oxidation and photoreceptor metabolic needs
Fu, Z., Kern, T. S., Hellström, A., & Smith, L. E. H. (2020) · Journal of Lipid Research · doi:10.1194/jlr.tr120000618 · Cited by 98 · see citing works
Glycol Chitosan Engineered Autoregenerative Antioxidant Significantly Attenuates Pathological Damages in Models of Age-Related Macular Degeneration
Mitra, R. N., Gao, R., Zheng, M., Wu, M. J., Voinov, M. A., Smirnov, A. I., Smirnova, T. I., Wang, K., Chavala, S. H., & Han, Z. (2017) · ACS Nano · doi:10.1021/acsnano.7b00429 · Cited by 94 · see citing works
Resveratrol Inhibits Pathologic Retinal Neovascularization inVldlr−/−Mice
Hua, J., Guerin, K. I., Chen, J., Michán, S., Stahl, A., Krah, N. M., Seaward, M. R., Dennison, R. J., Juan, A. M., Hatton, C. J., et al. (2011) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.10-6496 · Cited by 94 · see citing works
Recombinant Adeno-Associated Viral Vectors (rAAV)-Vector Elements in Ocular Gene Therapy Clinical Trials and Transgene Expression and Bioactivity Assays
Buck, T., & Wijnholds, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124197 · Cited by 92 · see citing works
“CHX10 164 Retinal progenitor cells [98] GFAP 2600 Müller glial cells, [99,100] GFAP 2200 Müller glial cells (Novartis) [101] GfaABC1D 686 Müller glial cells [96,97]”
Background
Sustained protection against photoreceptor degeneration in tubby mice by intravitreal injection of nanoceria
Cai, X., Sezate, S. A., Seal, S., & McGinnis, J. F. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.08.030 · Cited by 91 · see citing works
Sustained inhibition of neovascularization in vldlr mice following intravitreal injection of cerium oxide nanoparticles and the role of the ASK1-P38/JNK-NF-κB pathway
Cai, X., Seal, S., & McGinnis, J. F. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.10.022 · Cited by 90 · see citing works
Ciliary Neurotrophic Factor for Macular Telangiectasia Type 2: Results From a Phase 1 Safety Trial
Chew, E. Y., Clemons, T. E., Pető, T., Sallo, F. B., Ingerman, A., Tao, W., Singerman, L. J., Schwartz, S. D., Peachey, N. S., & Bird, A. C. (2014) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2014.12.013 · Cited by 88 · see citing works
Self-citation
Müller cells as a target for retinal therapy
Devoldere, J., Peynshaert, K., Smedt, S. C. D., & Remaut, K. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.01.023 · Cited by 88 · see citing works
Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos
Sun, Y., Lin, Z., Liu, C., Gong, Y. Q., Liegl, R. G.-H., Fredrick, T. W., Meng, S. S., Burnim, S. B., Wang, Z., Akula, J. D., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20161645 · Cited by 84 · see citing works
Nanoceria inhibit expression of genes associated with inflammation and angiogenesis in the retina of Vldlr null mice
Kyosseva, S. V., Chen, L., Seal, S., & McGinnis, J. F. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.08.003 · Cited by 82 · see citing works
Idiopathic macular telangiectasia type 2 (idiopathic juxtafoveolar retinal telangiectasis type 2A, Mac Tel 2)
Wu, L., Evans, T., & Arévalo, J. F. (2013) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2012.11.007 · Cited by 79 · see citing works
Frizzled 4 Is Required for Retinal Angiogenesis and Maintenance of the Blood-Retina Barrier
Paes, K., Wang, E., Henze, K., Vogel, P., Read, R. W., Suwanichkul, A., Kirkpatrick, L., Potter, D., Newhouse, M. M., & Rice, D. S. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-7146 · Cited by 78 · see citing works
The Role of Müller Cells in Diabetic Macular Edema
Lai, D., Wu, Y., Shao, C., & Qiu, Q. (2023) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.64.10.8 · Cited by 78 · see citing works
Omega-3 polyunsaturated fatty acids preserve retinal function in type 2 diabetic mice
Sapieha, P. S., Chen, J., Stahl, A., Seaward, M. R., Favazza, T. L., Juan, A. M., Hatton, C., Joyal, J.-S., Krah, N. M., Dennison, R. J., et al. (2012) · Nutrition and Diabetes · doi:10.1038/nutd.2012.10 · Cited by 72 · see citing works
Endothelial SRF/MRTF ablation causes vascular disease phenotypes in murine retinae
Weinl, C., Riehle, H., Park, D., Stritt, C., Beck, S. C., Huber, G., Wolburg, H., Olson, E. N., Seeliger, M. W., Adams, R. H., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64201 · Cited by 68 · see citing works
Nuclear receptor RORα regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation
Sun, Y., Liu, C., SanGiovanni, J. P., Evans, L. P., Tian, K. T., Zhang, B., Stahl, A., Pu, W. T., Kamenecka, T. M., Solt, L. A., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1504387112 · Cited by 68 · see citing works
Vectors and Gene Delivery to the Retina
Planul, A., & Dalkara, D. (2017) · Annual Review of Vision Science · doi:10.1146/annurev-vision-102016-061413 · Cited by 67 · see citing works
Disruption of De Novo Serine Synthesis in Müller Cells Induced Mitochondrial Dysfunction and Aggravated Oxidative Damage
Zhang, T., Gillies, M. C., Madigan, M. C., Shen, W., Du, J., Grünert, U., Zhou, F., Yam, M., & Zhu, L. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0840-8 · Cited by 67 · see citing works
Changes in adeno-associated virus-mediated gene delivery in retinal degeneration
Kolstad, K. D., Dalkara, D., Guerin, K., Visel, M., Hoffmann, N., Schaffer, D. V., & Flannery, J. G. (2010) · Human Gene Therapy · doi:10.1089/hum.2009.194 · Cited by 63 · see citing works
Assessment of Inner Blood–Retinal Barrier: Animal Models and Methods
Bora, K., Kushwah, N. S., Maurya, M., Pavlovich, M. C., Wang, Z., & Chen, J. (2023) · Cells · doi:10.3390/cells12202443 · Cited by 65 · see citing works
Oxidative stress: The achilles' heel of neurodegenerative diseases of the retina
Cai, X. (2011) · Frontiers in bioscience · doi:10.2741/4033 · Cited by 62 · see citing works
Therapeutic importance of hydrogen sulfide in age-associated neurodegenerative diseases
Jeong, N., Jung, J., & Tabassum, R. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.266911 · Cited by 61 · see citing works
Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting
Westenskow, P. D., Kurihara, T., Aguilar, E., Scheppke, E. L., Moreno, S. K., Wittgrove, C. M., Marchetti, V., Michael, I. P., Anand, S., Nagy, A., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70230 · Cited by 60 · see citing works
Self-citation
A Standardized Extract of the Fruit of Ziziphus jujuba (Jujube) Induces Neuronal Differentiation of Cultured PC12 Cells: A Signaling Mediated by Protein Kinase A
Chen, J., Maiwulanjiang, M., Lam, K. Y. C., Zhang, L., Zhan, J. Y.-X., Lam, C. T. W., Xu, S. L., Zhu, K. Y., Yao, P., Lau, D. T. W., et al. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf405093f · Cited by 58 · see citing works
Angiogenesis and Eye Disease
Usui, Y., Westenskow, P. D., Murinello, S., Dorrell, M. I., Scheppke, L., Bucher, F., Sakimoto, S., Paris, L. P., Aguilar, E., & Friedlander, M. (2015) · Annual Review of Vision Science · doi:10.1146/annurev-vision-082114-035439 · Cited by 57 · see citing works
Self-citation
Neuronal-Driven Angiogenesis: Role of NGF in Retinal Neovascularization in an Oxygen-Induced Retinopathy Model
Liu, X., Wang, D., Liu, Y., Luo, Y., Ma, W., Xiao, W., & Yu, Q. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4226 · Cited by 51 · see citing works
TMP Prevents Retinal Neovascularization and Imparts Neuroprotection in an Oxygen-Induced Retinopathy Model
Liang, X., Zhou, H. J., Ding, Y., Li, J., Yang, C., Luo, Y., Li, S., Sun, G., Liao, X., & Wang, M. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-9315 · Cited by 48 · see citing works
Decoding Noncoding RNAs: Role of MicroRNAs and Long Noncoding RNAs in Ocular Neovascularization
Zhang, Y., Cai, S., Jia, Y., Chen, Q., Sun, J., Zhang, H., Wang, F., Cao, Y., & Li, X. (2017) · Theranostics · doi:10.7150/thno.19646 · Cited by 48 · see citing works
Nutritional supplements in age‐related macular degeneration
Schmidl, D., Garhöfer, G., & Schmetterer, L. (2015) · Acta ophthalmologica · doi:10.1111/aos.12650 · Cited by 97 · see citing works
Evaluation of Potential Therapies for a Mouse Model of Human Age-Related Macular Degeneration Caused by Delayed all- trans -Retinal Clearance
Maeda, T., Maeda, A., Matosky, M., Okano, K., Roos, S. S., Tang, J. C. O., & Palczewski, K. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3581 · Cited by 47 · see citing works
RETINAL–CHOROIDAL ANASTOMOSIS IN MACULAR TELANGIECTASIA TYPE 2
Spaide, R. F., Yannuzzi, L. A., & Maloca, P. M. (2018) · Retina · doi:10.1097/iae.0000000000002289 · Cited by 46 · see citing works
Retinal microglia are critical for subretinal neovascular formation
Usui‐Ouchi, A., Usui, Y., Kurihara, T., Aguilar, E., Dorrell, M. I., Ideguchi, Y., Sakimoto, S., Bravo, S., & Friedlander, M. (2020) · JCI Insight · doi:10.1172/jci.insight.137317 · Cited by 44 · see citing works
Self-citation
Inherited Retinal Dystrophies: Role of Oxidative Stress and Inflammation in Their Physiopathology and Therapeutic Implications
Pinilla, I., Maneu, V., Campello, L., Fernández‐Sánchez, L., Martínez‐Gil, N., Kutsyr, O., Sánchez‐Sáez, X., Sánchez‐Castillo, C., Lax, P., & Cuenca, N. (2022) · Antioxidants · doi:10.3390/antiox11061086 · Cited by 44 · see citing works
Multi-Functional OCT Enables Longitudinal Study of Retinal Changes in a VLDLR Knockout Mouse Model
Augustin, M., Fialová, S., Himmel, T., Glösmann, M., Lengheimer, T., Harper, D. J., Plasenzotti, R., Pircher, M., Hitzenberger, C. K. F., & Baumann, B. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164419 · Cited by 43 · see citing works
Mechanism of Cone Degeneration in Retinitis Pigmentosa
Song, D.-J., Bao, X.-L., Fan, B., & Li, G. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01243-2 · Cited by 43 · see citing works
Stemming vision loss with stem cells
Marchetti, V., Krohne, T. U., Friedlander, D. F., & Friedlander, M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42951 · Cited by 42 · see citing works
Self-citation
Involvement of NT3 and P75NTR in photoreceptor degeneration following selective Müller cell ablation
Shen, W., Zhu, L., Lee, S.-R., Chung, S. H., & Gillies, M. C. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-137 · Cited by 41 · see citing works
CHARACTERISTICS OF PIGMENTED LESIONS IN TYPE 2 IDIOPATHIC MACULAR TELANGIECTASIA
Leung, I., Sallo, F. B., Bonelli, R., Clemons, T. E., Pauleikhoff, D., Chew, E. Y., Bird, A. C., Pető, T., & the MacTel Study Group (2017) · Retina · doi:10.1097/iae.0000000000001842 · Cited by 41 · see citing works
Self-citation
Nanoparticle-Mediated Expression of a Wnt Pathway Inhibitor Ameliorates Ocular Neovascularization
Wang, Z., Cheng, R., Lee, K., Tyagi, P., Ding, L., Kompella, U. B., Chen, J., Xu, X., & Ma, J. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304627 · Cited by 40 · see citing works
Macular Telangiectasia Type 2: A Comprehensive Review
Chandra, K. K., Narayanan, R., Stewart, M. W., Reddy, N. G., & Khanani, A. M. (2022) · Clinical ophthalmology · doi:10.2147/opth.s373538 · Cited by 38 · see citing works
Increase of 8-Hydroxy-2′-Deoxyguanosine in Aqueous Humor of Patients with Exudative Age-Related Macular Degeneration
Lau, L.-I., Liu, C. J.-L., & Wei, Y. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5663 · Cited by 38 · see citing works
Hypoxia-regulated retinal glial cell-specific promoter for potential gene therapy in disease
Prentice, H. M., Biswal, M. R., Dorey, C. K., & Blanks, J. C. (2011) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.10-6835 · Cited by 35 · see citing works
The 20th Anniversary of Pegaptanib (MacugenTM), the First Approved Aptamer Medicine: History, Recent Advances and Future Prospects of Aptamers in Therapy
Bege, M., Kattoub, R. G., & Borbás, A. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17030394 · Cited by 38 · see citing works
Adeno-Associated Virus Mediated Gene Therapy for Retinal Degenerative Diseases
Stieger, K., Cronin, T., Bennett, J., & Rolling, F. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-370-7_8 · Cited by 35 · see citing works
Prevention of VEGF-induced growth and tube formation in human retinal endothelial cells by aldose reductase inhibition
Yadav, U. C. S., Srivastava, S. K., & Ramana, K. V. (2012) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2012.04.017 · Cited by 35 · see citing works
Cell-Based Ciliary Neurotrophic Factor Therapy for Macular Telangiectasia Type 2
Chew, E. Y., Gillies, M., Jaffe, G. J., Gaudric, A., Egan, C. A., Constable, I. J., Clemons, T. E., Aaberg, T. M., Manning, D. C., Hohman, T. C., et al. (2025) · NEJM Evidence · doi:10.1056/evidoa2400481 · Cited by 32 · see citing works
Self-citation
The Role of Hypoxia, Hypoxia-Inducible Factor (HIF), and VEGF in Retinal Angiomatous Proliferation
Barben, M., Samardzija, M., & Grimm, C. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-75402-4_22 · Cited by 30 · see citing works
Retinal Degeneration Progression Changes Lentiviral Vector Cell Targeting in the Retina
Calame, M., Cachafeiro, M. C. B., Philippe, S., Schouwey, K., Tekaya, M., Wanner, D., Sarkis, C., Kostic, C., & Arsenijévic, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023782 · Cited by 29 · see citing works
The increased toxicity of UV-degraded nitroguanidine and IMX-101 to zebrafish larvae: Evidence implicating oxidative stress
Gust, K. A., Stanley, J. K., Wilbanks, M. S., Mayo, M. L., Chappell, P., Jordan, S. M., Moores, L. C., Kennedy, A. R., & Barker, N. D. (2017) · Aquatic Toxicology · doi:10.1016/j.aquatox.2017.07.004 · Cited by 29 · see citing works
Antibody-Mediated Inhibition of Tspan12 Ameliorates Vasoproliferative Retinopathy Through Suppression of β-Catenin Signaling
Bucher, F., Zhang, D., Aguilar, E., Sakimoto, S., Diaz‐Aguilar, M. S., Rosenfeld, M., Zha, Z., Zhang, H., Friedlander, M., & Yea, K. (2017) · Circulation · doi:10.1161/circulationaha.116.025604 · Cited by 28 · see citing works
Self-citation
Müller cells and retinal angiogenesis: critical regulators in health and disease
Arellano, A. E. M., Albert-Garay, J. S., Medina-Sánchez, T., Hernández‐Fonseca, K., Ruiz‐Cruz, M., & la Paz, L. D. O.-D. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1513686 · Cited by 27 · see citing works
Triglyceride-derived fatty acids reduce autophagy in a model of retinal angiomatous proliferation
Heckel, É., Cagnone, G., Agnihotri, T., Cakir, B., Das, A., Kim, J. S., Kim, N., Lavoie, G., Situ, A., Pundir, S., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.154174 · Cited by 27 · see citing works
VEGF-B inhibits hyperglycemia- and Macugen-induced retinal apoptosis
Huang, D., Zhao, C., Ju, R., Kumar, A., Tian, G., Huang, L., Zheng, L., Li, X., Liu, L., Wang, S., et al. (2016) · Scientific Reports · doi:10.1038/srep26059 · Cited by 26 · see citing works
Protective effect of clusterin on rod photoreceptor in rat model of retinitis pigmentosa
Vargas, A., Kim, H. S., Baral, E., Yu, W., Craft, C. M., & Lee, E.-J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182389 · Cited by 25 · see citing works
Clinical Pathological Features and Current Animal Models of Type 3 Macular Neovascularization
Qiang, W., Wei, R., Chen, Y., & Chen, D. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.734860 · Cited by 24 · see citing works
CNTF Prevents Development of Outer Retinal Neovascularization Through Upregulation of CxCl10
Bucher, F., Aguilar, E., Marra, K. V., Rapp, J., Arnold, J., Diaz‐Aguilar, M. S., Lange, C., Agostini, H. T., Schlunck, G., Stahl, A., et al. (2020) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.61.10.20 · Cited by 22 · see citing works
Self-citation
Cerium oxide nanoparticles as promising ophthalmic therapeutics for the treatment of retinal diseases
Kyosseva, S. V. (2015) · World Journal of Ophthalmology · doi:10.5318/wjo.v5.i1.23 · Cited by 22 · see citing works
A time and cost efficient approach to functional and structural assessment of living neuronal tissue
Toychiev, A. H., Sagdullaev, B., Yee, C. W., Ivanova, E., & Sagdullaev, B. T. (2013) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2013.01.016 · Cited by 21 · see citing works
The Role of Vldlr in Intraretinal Angiogenesis in Mice
Xia, C., Lu, E., Liu, H., Du, X., Beutler, B., & Gong, X. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-7082 · Cited by 20 · see citing works
MicroRNAs in laser-induced choroidal neovascularization in mice and rats: their expression and potential therapeutic targets
Peplow, P., & Martinez, B. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.295271 · Cited by 19 · see citing works
Spontaneous Posterior Segment Vascular Disease Phenotype of a Mouse Model, rnv3 , Is Dependent on the Crb1 rd8 Allele
Chang, B., FitzMaurice, B., Wang, J., Low, B. E., Wiles, M. V., & Nishina, P. M. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-25046 · Cited by 19 · see citing works
Thrombospondin-1 and Pathogenesis of Age-Related Macular Degeneration
Housset, M., & Sennlaub, F. (2015) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2015.0023 · Cited by 19 · see citing works
HYPERREFLECTIVITY ON OPTICAL COHERENCE TOMOGRAPHY IN MACULAR TELANGIECTASIA TYPE 2
Tzaridis, S., Pfau, K., Heeren, T. F. C., Bonelli, R., Holz, F. G., & Friedlander, M. (2021) · Retina · doi:10.1097/iae.0000000000003111 · Cited by 18 · see citing works
Self-citation
Local acting Sticky‐trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye
Michael, I. P., Westenskow, P. D., Hacibekiroglu, S., Greenwald, A., Ballios, B. G., Kurihara, T., Li, Z., Warren, C. M., Zhang, P., Aguilar, E., et al. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201303708 · Cited by 17 · see citing works
Self-citation
Functional Differences of Very-Low-Density Lipoprotein Receptor Splice Variants in Regulating Wnt Signaling
Chen, Q., Takahashi, Y., Oka, K., & Ma, J. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00235-16 · Cited by 17 · see citing works
Hydrogen Saline Treatment Attenuates Hyperoxia-Induced Retinopathy by Inhibition of Oxidative Stress and Reduction of VEGF Expression
Huang, L., Zhao, S., Zhang, J. H., & Sun, X. (2011) · Ophthalmic Research · doi:10.1159/000329600 · Cited by 16 · see citing works
Retracted
Encapsulated cell technology: Delivering cytokines to treat posterior ocular diseases
Wang, J., Fan, W., Liu, B., Pu, N., Wu, H., Xue, R., Li, S., Song, Z., & Tao, Y. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107159 · Cited by 14 · see citing works
Low-Dose Anti-HIV Drug Efavirenz Mitigates Retinal Vascular Lesions in a Mouse Model of Alzheimer’s Disease
El‐Darzi, N., Mast, N., Buchner, D. A., Saadane, A., Dailey, B., Trichonas, G., & Pikuleva, I. A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.902254 · Cited by 15 · see citing works
Neovascularization: Ocular Diseases, Animal Models and Therapies
Cai, X., Sezate, S. A., & McGinnis, J. F. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0631-0_32 · Cited by 13 · see citing works
Hyper-reflectivity on optical coherence tomography in macular telangiectasia type 2
Tzaridis, S., Hess, K., Heeren, T. F. C., Bonelli, R., Holz, F. G., & Friedlander, M. (2020) · Retina · doi:10.1097/iae.0000000000003031 · Cited by 12 · see citing works
Self-citation
Morphological and migratory alterations in retinal Müller cells during early stages of hypoxia and oxidative stress.
Zhang, X., Feng, Z., Li, C., & Zheng, Y. (2012) · Europe PMC (PubMed Central) · doi:10.3969/j.issn.1673-5374.2012.01.005 · Cited by 12 · see citing works
Deletion of LRP5 in VLDLR Knockout Mice Inhibits Retinal Neovascularization
Xia, C., Lu, E., Zeng, J., & Gong, X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075186 · Cited by 11 · see citing works
Neurite Mistargeting and Inverse Order of Intraretinal Vascular Plexus Formation Precede Subretinal Vascularization in Vldlr Mutant Mice
Johnson, V. R., Xiang, M., Chen, Z., & Junge, H. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132013 · Cited by 11 · see citing works
La conception de vecteurs adaptés à la thérapie génique oculaire
Khabou, H., & Dalkara, D. (2015) · médecine/sciences · doi:10.1051/medsci/20153105015 · Cited by 11 · see citing works
Photoreceptors inhibit pathological retinal angiogenesis through transcriptional regulation of Adam17 via c-Fos
Wang, X., Wang, T., Kaneko, S., Kriukov, E., Lam, E., Szczepan, M., Chen, J., Gregg, A. T., Wang, X., Fernandez‐Gonzalez, A., et al. (2024) · Angiogenesis · doi:10.1007/s10456-024-09912-0 · Cited by 9 · see citing works
Transcriptional and Distributional Profiling of Microglia in Retinal Angiomatous Proliferation
Schlecht, A., Wolf, J., Boneva, S., Prinz, G., Braunger, B. M., Wieghofer, P., Agostini, H. T., Schlunck, G., & Lange, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073443 · Cited by 9 · see citing works
Strategies to Improve the Targeting of Retinal Cells by Non-Viral Gene Therapy Vectors
Bitoque, D. B., Fernandes, C. F., Oliveira, A. M. L., & Silva, G. A. (2022) · Frontiers in Drug Delivery · doi:10.3389/fddev.2022.899260 · Cited by 9 · see citing works

Antioxidant Treatment Rescues Oxidative Stress-Induced Photoreceptor Degeneration That Results From Intraretinal and Subretinal Neovascularization in vldlr-/- Mice
Dorrell, M. I., Aguilar, E., Jacobson, R., Gariano, R. F., Heckenlively, J. R., Banin, E., & Friedlander, M. (2008) · Investigative Ophthalmology & Visual Science
Self-citation
Nanoceria Inhibit the Development and Promote the Regression of Pathologic Retinal Neovascularization in the Vldlr Knockout Mouse
¤a, X. Z., Wong, L. L., Karakoti, A. S., Seal, S., & McGinnis, J. F. (2013)
Inhibition of Vascular Endothelial Growth Factor Reduces Photoreceptor Death in Retinal Neovascular Disease via Neurotrophic Modulation in Müller Glia
Gao, S., Gao, S., Wang, Y., Lu, X., Peng, H., Chen, G., Xu, J., Zhang, Q., Zhu, C., Zhou, Y., et al. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04689-9 · Cited by 5 · see citing works
Melatonin ameliorates retinal neurovascular degeneration in Rd1 mice by inhibiting oxidativestress
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Nitro-Oleic acid protects from neovascularization, oxidative stress, gliosis and neurodegeneration in oxygen-induced retinopathy
Vaglienti, M. V., Paz, M. C., Gutierrez, M. V., Subirada, P. V., Luna, J., Bonacci, G., & Sanchez, M. C. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103634 · Cited by 4 · see citing works

Authors: Dorrell, M. I., Aguilar, E., Jacobson, R., Yanes, O., Gariano, R., Heckenlively, J., Banin, E., Ramirez, G. A., Gasmi, M., Bird, A., Siuzdak, G., & Friedlander, M.
Affiliations: Scripps Research Institute (US)
University of Michigan (US)
Hadassah Medical Center (IL)
Moorfields Eye Hospital (GB)
Corresponding author: Friedlander, Martin
ORCID: Dorrell, Michael I.
Aguilar, Edith
Banin, Eyal
Bird, Alan
Siuzdak, Gary
Friedlander, Martin
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2009-03-02
Volume: 119
Issue: 3
Pages: 611-623
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci35977
PMC: PMC2648679
OpenAlex: W1999304307
Cited by: 127
References: 57
Citations by year: 2026: 4 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 9 · 2021: 5 · 2020: 8 · 2019: 2 · 2018: 6 · 2017: 15 · 2016: 4 · 2015: 9 · 2014: 7 · 2013: 9 · 2012: 15
FWCI: 12.53
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: California Institute for Regenerative Medicine
V. Kann Rasmussen Foundation
National Institutes of Health
National Eye Institute (R01EY011254)
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
Keywords: neovascularization, oxidative stress, photoreceptor degeneration, retinal angiomatous proliferation, macular telangiectasia, VLDL receptor, antioxidant supplementation, neurotrophic factor delivery, Müller cells, viral gene delivery, retinal function, cone opsin, rod opsin, electroretinogram
MeSH terms: Animals, Antioxidants, Disease Models, Animal, Electroretinography, Mice, Inbred C57BL, Nerve Growth Factors, Receptors, LDL, Retina, Retinitis Pigmentosa, Rhodopsin, Lipid Peroxidation, Retinal Neovascularization, Gene Expression, Retinal Rod Photoreceptor Cells, Retinal Cone Photoreceptor Cells, Gene Transfer Techniques, Mice, Knockout, Oxidative Stress, Angiogenesis Inhibitors, Gene Expression Profiling, Vascular Endothelial Growth Factor A, Mice, Aptamers, Nucleotide, Retinal Pigment Epithelium, Opsins

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Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress

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