The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Decreased Retinal Ganglion Cell Layer Thickness in Patients with Type 1 Diabetes
Open accessAbstract
PURPOSE. To determine which retinal layers are most affected by diabetes and contribute to thinning of the inner retina and to investigate the relationship between retinal layer thickness (LT) and diabetes duration, diabetic retinopathy (DR) status, age, glycosylated hemoglobin (HbA1c), and the sex of the individual, in patients with type 1 diabetes who have no or minimal DR. METHODS. Mean LT was calculated for the individual retinal layers after automated segmentation of spectral domain-optical coherence tomography scans of patients with diabetes and compared with that in control subjects. Multiple linear regression analysis was used to determine the relationship between LT and HbA1c, age, sex, diabetes duration, and DR status. RESULTS. In patients with minimal DR, the mean ganglion cell layer (GCL) in the pericentral area was 5.1 mum thinner (95% confidence interval [CI], 1.1-9.1 mum), and in the peripheral macula, the mean retinal nerve fiber layer (RNFL) was 3.7 mum thinner (95% CI, 1.3-6.1 mum) than in the control subjects. There was a significant linear correlation (R = 0.53, P < 0.01) between GCL thickness and diabetes duration in the pooled group of patients. Multiple linear regression analysis (R = 0.62, P < 0.01) showed that DR status was the most important explanatory variable. CONCLUSIONS. This study demonstrates GCL thinning in the pericentral area and corresponding loss of RNFL thickness in the peripheral macula in patients with type 1 diabetes and no or minimal DR compared with control subjects. These results support the concept that diabetes has an early neurodegenerative effect on the retina, which occurs even though the vascular component of DR is minimal.
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Abràmoff, M. D., Magalhães, P. J., & Ram, S. J. (2004) · Utrecht University Repository (Utrecht University) · Cited by 11,821
Self-citationWilkinson, C. P., Ferris, F. L., Klein, R. E., Lee, P. P., Agardh, C. D., Davis, M., Dills, D., Kampik, A., Pararajasegaram, R., & Verdaguer, J. T. (2003) · Ophthalmology · doi:10.1016/s0161-6420(03)00475-5 · Cited by 3,743
Barber, A. J., Lieth, E., Khin, S. A., Antonetti, D. A., Buchanan, A. G., & Gardner, T. W. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2425 · Cited by 1,295
Antonetti, D. A., Barber, A. J., Bronson, S. K., Freeman, W. M., Gardner, T. W., Jefferson, L. S., Kester, M., Kimball, S. R., Krady, J. K., LaNoue, K. F., et al. (2006) · Diabetes · doi:10.2337/db05-1635 · Cited by 746
Garway-Heath, D. F., Poinoosawmy, D., Fitzke, F. W., & Hitchings, R. A. (2000) · Ophthalmology · doi:10.1016/s0161-6420(00)00284-0 · Cited by 737
Long-term effect of diabetes and its treatment on cognitive function
(2007) · New England Journal of Medicine · doi:10.1056/nejmoa066397 · Cited by 646
Garvin, M. K., Abramoff, M. D., Wu, X., Russell, S. R., Burns, T. L., & Sonka, M. (2009) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2009.2016958 · Cited by 626
Self-citationA new view of diabetic retinopathy: a neurodegenerative disease of the eye
Barber, A. J. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00023-x · Cited by 622
Glial reactivity, an early feature of diabetic retinopathy.
Rungger‐Brändle, E., Dosso, A., & Leuenberger, P. (2000) · PubMed · Cited by 509
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Antonetti, D. A., Klein, R., & Gardner, T. W. (2012) · New England Journal of Medicine · doi:10.1056/nejmra1005073 · Cited by 1,659
Diabetic retinopathy: current understanding, mechanisms, and treatment strategies
Duh, E. J., Sun, J. K., & Stitt, A. W. (2017) · JCI Insight · doi:10.1172/jci.insight.93751 · Cited by 1,057
Neurodegeneration in the diabetic eye: new insights and therapeutic perspectives
Simó, R., & Hernández, C. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2013.09.005 · Cited by 490
Scott, I. U., Jackson, G. R., Quillen, D. A., Larsen, M., Klein, R., Liao, J., Holfort, S., Munch, I. C., & Gardner, T. W. (2014) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2014.93 · Cited by 59
Effects of Coconut Water on Retina in Diabetic Rats
Zhang, X., Peng, L., Dai, Y., Sheng, X., Chen, S., & Xie, Q. (2020) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2020/9450634 · Cited by 14
Metadata
- Authors
- van Dijk, H. W., Verbraak, F. D., Kok, P. H. B., Garvin, M. K., Sonka, M., Lee, K., DeVries, J. H., Michels, R. P. J., van Velthoven, M. E. J., Schlingemann, R. O., & Abràmoff, M. D.
- Venue
- Investigative Opthalmology & Visual Science
- Published
- 2010-07-01
- Volume
- 51
- Issue
- 7
- Pages
- 3660
- ISSN
- 0146-0404 (ISSN-L)
- 1552-5783
- OpenAlex
- W2162377737
- Cited by
- 359
- References
- 31
- FWCI
- 17.80
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- van Dijk, H. W., Verbraak, F. D., Kok, P. H. B., Garvin, M. K., Sonka, M., Lee, K., DeVries, J. H., Michels, R. P. J., van Velthoven, M. E. J., Schlingemann, R. O., & Abràmoff, M. D. (2010). Decreased Retinal Ganglion Cell Layer Thickness in Patients with Type 1 Diabetes. Investigative Opthalmology & Visual Science. https://doi.org/10.1167/iovs.09-5041
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