The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Quantifying Microvascular Density and Morphology in Diabetic Retinopathy Using Spectral-Domain Optical Coherence Tomography Angiography
Open accessAbstract
PURPOSE: To quantify changes in retinal microvasculature in diabetic retinopathy (DR) by using spectral-domain optical coherence tomography angiography (SD-OCTA). METHODS: Retrospective, cross-sectional, observational study of healthy and diabetic adult subjects with and without DR. Retinal microvascular changes were assessed by using SD-OCTA images and an intensity-based optical microangiography algorithm. A semiautomated program was used to calculate indices of microvascular density and morphology in nonsegmented and segmented SD-OCTA images. Microvascular density was quantified by using skeleton density (SD) and vessel density (VD), while vessel morphology was quantified as fractal dimension (FD) and vessel diameter index (VDI). Statistical analyses were performed by using the Student's t-test or analysis of variance with post hoc Tukey honest significant difference tests for multiple comparisons. RESULTS: Eighty-four eyes with DR and 14 healthy eyes were studied. Spearman's rank test demonstrated a negative correlation between DR severity and SD, VD, and FD, and a positive correlation with VDI (ρ = -0.767, -0.7166, -0.768, and +0.5051, respectively; P < 0.0001). All parameters showed high reproducibility between graders (ICC = 0.971, 0.962, 0.937, and 0.994 for SD, VD, FD, and VDI, respectively). Repeatability (κ) was greater than 0.99 for SD, VD, FD, and VDI. CONCLUSIONS: Vascular changes in DR can be objectively and reliably characterized with SD, VD, FD, and VDI. In general, decreasing capillary density (SD and VD), branching complexity (FD), and increasing average vascular caliber (VDI) were associated with worsening DR. Changes in capillary density and morphology were significantly correlated with diabetic macular edema.
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Wilkinson, C. P., Ferris, F. L., Klein, R. E., Lee, P. P., Agardh, C. D., Davis, M., Dills, D., Kampik, A., Pararajasegaram, R., & Verdaguer, J. T. (2003) · Ophthalmology · doi:10.1016/s0161-6420(03)00475-5 · Cited by 3,743
Klein, R. (1984) · Archives of Ophthalmology · doi:10.1001/archopht.1984.01040030398010 · Cited by 1,885
Split-spectrum amplitude-decorrelation angiography with optical coherence tomography
Jia, Y., Tan, O., Tokayer, J., Potsaid, B., Wang, Y., Liu, J. J., Kraus, M. F., Subhash, H., Fujimoto, J. G., Hornegger, J., et al. (2012) · Optics Express · doi:10.1364/oe.20.004710 · Cited by 1,841
Spaide, R. F., Klancnik, J. M., & Cooney, M. J. (2015) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2014.3616 · Cited by 1,620
Klein, R. (1984) · Archives of Ophthalmology · doi:10.1001/archopht.1984.01040030405011 · Cited by 1,477
Overview of Epidemiologic Studies of Diabetic Retinopathy
Kobrin Klein, B. E. (2007) · Ophthalmic Epidemiology · doi:10.1080/09286580701396720 · Cited by 734
Jia, Y., Bailey, S. T., Wilson, D. J., Tan, O., Klein, M. L., Flaxel, C. J., Potsaid, B., Liu, J. J., Lu, C. D., Kraus, M. F., et al. (2014) · Ophthalmology · doi:10.1016/j.ophtha.2014.01.034 · Cited by 729
Jia, Y., Bailey, S. T., Hwang, T. S., McClintic, S. M., Gao, S. S., Pennesi, M. E., Flaxel, C. J., Lauer, A. K., Wilson, D. J., Hornegger, J., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1500185112 · Cited by 665
Optical Coherence Tomography Angiography in Diabetic Retinopathy: A Prospective Pilot Study
Ishibazawa, A., Nagaoka, T., Takahashi, A., Omae, T., Tani, T., Sogawa, K., Yokota, H., & Yoshida, A. (2015) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2015.04.021 · Cited by 617
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Guidelines on Diabetic Eye Care
Wong, T. Y., Sun, J., Kawasaki, R., Ruamviboonsuk, P., Gupta, N., Lansingh, V. C., Maia, M., Mathenge, W., Moreker, S., Muqit, M. M. K., et al. (2018) · Ophthalmology · doi:10.1016/j.ophtha.2018.04.007 · Cited by 839
Diabetic Retinopathy Preferred Practice Pattern®
Flaxel, C. J., Adelman, R. A., Bailey, S. T., Fawzi, A., Lim, J. I., Vemulakonda, G. A., & Ying, G.-S. (2020) · Ophthalmology · doi:10.1016/j.ophtha.2019.09.025 · Cited by 717
Dimitrova, G., Chihara, E., Takahashi, H., Amano, H., & Okazaki, K. (2017) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.16-20531 · Cited by 309
Carnevali, A., Sacconi, R., Corbelli, E., Tomasso, L., Querques, L., Zerbini, G., Scorcia, V., Bandello, F., & Querques, G. (2017) · Acta Diabetologica · doi:10.1007/s00592-017-0996-8 · Cited by 263
Metadata
- Authors
- Kim, A. Y., Chu, Z., Shahidzadeh, A., Wang, R. K., Puliafito, C. A., & Kashani, A. H.
- Venue
- Investigative Opthalmology & Visual Science
- Published
- 2016-07-13
- Volume
- 57
- Issue
- 9
- Pages
- OCT362
- ISSN
- 0146-0404 (ISSN-L)
- 1552-5783
- OpenAlex
- W2461701740
- Cited by
- 502
- References
- 30
- FWCI
- 40.21
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kim, A. Y., Chu, Z., Shahidzadeh, A., Wang, R. K., Puliafito, C. A., & Kashani, A. H. (2016). Quantifying Microvascular Density and Morphology in Diabetic Retinopathy Using Spectral-Domain Optical Coherence Tomography Angiography. Investigative Opthalmology & Visual Science. https://doi.org/10.1167/iovs.15-18904
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