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Split-spectrum amplitude-decorrelation angiography with optical coherence tomography
Open accessAbstract
Amplitude decorrelation measurement is sensitive to transverse flow and immune to phase noise in comparison to Doppler and other phase-based approaches. However, the high axial resolution of OCT makes it very sensitive to the pulsatile bulk motion noise in the axial direction. To overcome this limitation, we developed split-spectrum amplitude-decorrelation angiography (SSADA) to improve the signal-to-noise ratio (SNR) of flow detection. The full OCT spectrum was split into several narrower bands. Inter-B-scan decorrelation was computed using the spectral bands separately and then averaged. The SSADA algorithm was tested on in vivo images of the human macula and optic nerve head. It significantly improved both SNR for flow detection and connectivity of microvascular network when compared to other amplitude-decorrelation algorithms.
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Cites
The mechanics of human saccadic eye movement
Robinson, D. A. (1964) · The Journal of Physiology · doi:10.1113/jphysiol.1964.sp007485 · Cited by 893
Cited by
Takase, N., Nozaki, M., Kato, A., Ozeki, H., Yoshida, M., & Ogura, Y. (2015) · Retina · doi:10.1097/iae.0000000000000849 · Cited by 474
Hwang, T. S., Gao, S. S., Liu, L., Lauer, A. K., Bailey, S. T., Flaxel, C. J., Wilson, D. J., Huang, D., & Jia, Y. (2016) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2015.5658 · Cited by 389
Self-citationTan, G. S., Cheung, N., Simó, R., Cheung, G. C. M., & Wong, T. Y. (2017) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)30052-3 · Cited by 361
Spaide, R. F. (2015) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2015.04.012 · Cited by 313
Optical coherence tomography imaging for glaucoma - today and tomorrow
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Metadata
- Authors
- Jia, Y., Tan, O., Tokayer, J., Potsaid, B., Wang, Y., Liu, J. J., Kraus, M. F., Subhash, H., Fujimoto, J. G., Hornegger, J., & Huang, D.
- Venue
- Optics Express
- Publisher
- Optica Publishing Group
- Published
- 2012-02-09
- Volume
- 20
- Issue
- 4
- Pages
- 4710
- ISSN
- 1094-4087 (ISSN-L)
- OpenAlex
- W1528934530
- Cited by
- 1,841
- References
- 1
- FWCI
- 23.37
- Type
- journal article
- Language
- en
- Open access
- gold
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- Jia, Y., Tan, O., Tokayer, J., Potsaid, B., Wang, Y., Liu, J. J., Kraus, M. F., Subhash, H., Fujimoto, J. G., Hornegger, J., & Huang, D. (2012). Split-spectrum amplitude-decorrelation angiography with optical coherence tomography. Optics Express. https://doi.org/10.1364/oe.20.004710
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